Abstract:
OBJECTIVE:To present the renal functional outcomes for patients treated with open partial nephrectomy (OPN) or radiofrequency ablation (RFA) for tumours in a solitary kidney, as renal masses in a solitary kidney present a challenging treatment dilemma. PATIENTS AND METHODS:A retrospective review of institutional databases identified 89 patients with 98 renal tumours in a solitary kidney managed by RFA or OPN under cold ischaemia between January 1997 and September 2007. The choice of therapy was based on patient and surgeon preference, tumour characteristics and comorbidities. Renal function was calculated using the modified Modification of Diet in Renal Disease equation. RESULTS:Outcomes from 47 patients treated by RFA and 42 by OPN were analysed at a median follow-up of 18.1 and 30.0 months, respectively (P = 0.02). The median age (65.9 vs 59.6 years, P = 0.03) and American Society of Anesthesiology score (3.0 vs 2.0, P = 0.01) were both higher in patients treated with RFA. The median tumour size was greater for tumours managed by OPN (3.9 vs 2.8 cm, P = 0.001), while the median preoperative glomerular filtration rate (GFR) was lower in the RFA group (46.5 vs 55.9 mL/min/1.73 m(2) for OPN, P = 0.04). Compared to RFA, patients treated with OPN had a greater decline in GFR at all times evaluated, including soon after the procedure (15.8% vs 7.1%), 12 months after surgery (24.5% vs 10.4%) and at the last follow-up (28.6% vs 11.4%, all P < 0.001). For patients with a pretreatment GFR of > 60 or > 30 mL/min/1.73 m(2), there was a new onset of decline in GFR of <60 and <30 mL/min/1.73 m(2) in none and 7% of patients after RFA, and in 35% and 17% after OPN. CONCLUSION:Ablative techniques, which obviate ischaemic insults, might be a particularly attractive option for managing tumours in solitary renal units at risk of declining function. Renal functional outcomes compare favourably to extirpative surgery using cold ischaemia.
journal_name
BJU Intjournal_title
BJU internationalauthors
Raman JD,Raj GV,Lucas SM,Williams SK,Lauer EM,Ahrar K,Matin SF,Leveillee RJ,Cadeddu JAdoi
10.1111/j.1464-410X.2009.08776.xsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
496-500issue
4eissn
1464-4096issn
1464-410Xpii
BJU8776journal_volume
105pub_type
杂志文章,多中心研究abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Systems for image guidance during laparoscopic surgery can be broadly defined as systems that enable the surgeon to refer to preoperatively gathered information during the procedure. For a laparoscopic system the preoperative information can be overl...
journal_title:BJU international
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To analyse telomerase activity in disseminated prostate cancer cells isolated from bone marrow aspirates taken from men with localized prostate cancer before radical prostatectomy (RP). PATIENTS AND METHODS:Disseminated epithelial prostate cancer cells were isolated from bone marrow aspirates from 69 men wit...
journal_title:BJU international
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abstract:OBJECTIVE:To identify the likelihood of finding one or more positive lymph nodes (LNs) according to the number of LNs removed at radical cystectomy (RC), as the number of LNs removed affects disease progression and survival after RC. PATIENTS AND METHODS:Between 1984 and 2003, 731 assessable patients had RC and bilate...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.08212.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of >1000 men with low-risk prostate cancer treated with low-dose-rate (LDR) brachytherapy at three large UK cancer centres. PATIENTS AND METHODS:A total of 1038 patients with low-risk prostate cancer (prostate-specific antigen [PSA] ≤10 ng/mL, Gleason score 6, ≤T2b disease) were treate...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
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abstract:UNLABELLED:What's known on the subject? and What does the study add? For the past 30 years Serenoa repens has become a widely used phytotherapy in the USA and in Europe, mostly because of positive comparisons to α-blockers and 5α-reductase inhibitors. During the last 4 years we have seen two very high quality trials co...
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pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11172.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate the high circumcision rate in South Korea and its rapid increase in the short period since its introduction. SUBJECTS AND METHODS:From January to December 2000, 5434 South Korean males (or their parents) aged 0-92 years were interviewed in detail about their circumcision status, their age at c...
journal_title:BJU international
pub_type: 杂志文章
doi:
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abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02981.x
更新日期:2002-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09417.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To assess the potentiation of erectile responses induced by electrical stimulation (ES) of the dorsal penile nerve (DPN) in the urethane-anaesthetized rat by the selective melanocortin receptor 4 agonist MB243. MATERIALS AND METHODS:Intracavernosal and blood pressures (ICP and BP, respectively) were monitore...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07751.x
更新日期:2008-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08848.x
更新日期:2010-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02776.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To assess the effects of testosterone supplementation in men with testosterone deficiency syndrome (TDS) after external beam radiotherapy (EBRT) for localized prostate cancer. PATIENTS AND METHODS:Five men with significant signs of TDS after treatment for localized prostate cancer with EBRT were treated with...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07882.x
更新日期:2009-01-01 00:00:00
abstract::OBJECTIVE To evaluate the indications for penile prosthesis implantation in the treatment of erectile dysfunction (ED) before and after the introduction of sildenafil. PATIENTS AND METHODS Penile prosthesis implantation was indicated in 144 men with ED at our institution between 1992 and 2007; 83 (55.6%) accepted the ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08356.x
更新日期:2009-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02047.x
更新日期:2001-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00162.x
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To explore the expression of transforming growth factor-beta(1) (TGF-beta1) in penile tissue from rats after bilateral cavernosal nerve (CN) ablation, mimicking patients who have had no nerve-sparing during prostatectomy. MATERIALS AND METHODS:Ten adult male rats (neurectomy group) had a bilateral CN resecti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04969.x
更新日期:2004-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.06771.x
更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.13515
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07760.x
更新日期:2008-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01795.x
更新日期:2002-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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更新日期:2014-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05779.x
更新日期:2005-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of a transportable extracorporeal shock wave lithotripsy (ESWL) machine, the Modulith SLX-F2(TM) (Storz Medical Italia, Rome, Italy), in the management of solitary urinary calculi. PATIENTS AND METHODS:The study included 233 patients (mean age 51 years; 172 male, 61 female) ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07039.x
更新日期:2007-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14027
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of zoledronic acid (ZA) in osteoporotic patients with prostate cancer receiving either luteinizing hormone-releasing hormone agonists (LHRHA, which accelerate bone loss) or bicalutamide (which preserves bone mineral density, BMD) as androgen-deprivation therapy is the mainstay of trea...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2009.08956.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To assess the predictive value of serial bone scans as a surveillance tool for bone metastasis in men with clinically localized prostate cancer and managed with watchful observation. PATIENTS AND METHODS:A prospective single-arm study was conducted to assess the feasibility of a watchful observation protocol...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04169.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To study the effect of 3 weeks of partial bladder outlet obstruction (BOO), compared to a sham operation, on the cholinergic and purinergic components of detrusor contractile responses to agonists and to electrical field stimulation (EFS); the expression of P2X receptor subtypes was also examined. MATERIALS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06010.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the effects of 50 mg mirabegron once daily for ureteric stent-related discomfort after ureteroscopic procedures by conducting a multicentre randomized study. PATIENTS AND METHODS:A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal su...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of OnabotulinumtoxinA (BTXA) injections in men with drug-refractory non-neurogenic overactive bladder (NNOAB). PATIENTS AND METHODS:A total of 43 men received BTXA injections for NNOAB from 2004 to 2012. Patient Global Impression of Improvement (PGI-I) score was obtained. For men with ...
journal_title:BJU international
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00