Abstract:
OBJECTIVE:To determine whether health-insurance status might result in more localized stage at presentation, more favourable stage at surgery and in a lower rate of biochemical recurrence (BCR), in patients diagnosed with prostate cancer and treated with radical prostatectomy (RP), as despite uninhibited access to healthcare, private and public health insurance are available in most European countries. PATIENTS AND METHODS:In all, 4442 consecutive men had RP in two large European centres, of whom 2372 had public and 2070 had private health insurance. The groups were compared for several variables according to insurance status (private vs public). Means and proportions tests were complemented with logistic regression or Kaplan-Meier analyses. RESULTS:Serum prostate-specific antigen level (P < 0.001), clinical stage (P < 0.001), pathological Gleason sum (P = 0.02), positive surgical margin rate (18.4% vs 25.4%, P < 0.001), extracapsular extension rate (17.7% vs 20.0%, P = 0.047) and seminal vesicle invasion rate (9.6% vs 11.6%, P = 0.04) were more favourable in privately insured patients. Conversely, the rate of lymph-node involvement was higher in those with private than public insurance (4.4% vs 3.3%, P = 0.045). In univariate analyses addressing pathological variables, private insurance was invariably protective (all P < 0.05). The Kaplan-Meier analyses showed that privately insured patients had a lower rate of BCR after RP (log-rank P = 0.017). CONCLUSION:Despite uninhibited access to healthcare, insurance status represents a rate-limiting variable, which affects stage at presentation and the outcome of cancer control.
journal_name
BJU Intjournal_title
BJU internationalauthors
Gallina A,Karakiewicz PI,Chun FK,Briganti A,Graefen M,Montorsi F,Walz J,Jeldres C,Erbersdobler A,Salonia A,Suardi N,Dehò F,Schlomm T,Scattoni V,Haese A,Heinzer H,Valiquette L,Rigatti P,Huland Hdoi
10.1111/j.1464-410X.2007.06771.xsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
1404-8issue
6eissn
1464-4096issn
1464-410Xpii
BJU6771journal_volume
99pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To characterise the outcomes of neoadjuvant chemotherapy (NAC) pre-treated patients found to be lymph node (LN)-positive at the time of radical cystectomy and pelvic lymph node dissection (RC/PLND) for urothelial carcinoma of the bladder (UCB). PATIENTS AND METHODS:Of 1484 patients treated with RC/PLND for ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14242
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. SUBJECTS AND METHODS:The study cohort comprised pr...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2012.11690.x
更新日期:2013-09-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after definitive local therapy. The objective of our present study was to summarise available evid...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2012.11527.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07793.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:To assess atypical cytology as a positive bladder tumour marker and to determine if indexing atypical cytology to nuclear matrix protein-22 (NMP22) can decrease the false-positive results or increase the positive predictive value (PPV). PATIENTS AND METHODS:In all, 197 patients at risk of bladder cancer wer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07789.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:To compare the metabolic changes between men with advanced prostate cancer commenced on a gonadotropin-releasing hormone (GnRH) agonist and those treated with orchiectomy. PATIENTS AND METHODS:Fifty-eight hormone-naive men with advanced prostate cancer were randomly assigned (1:1) to either subcapsular orch...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.14609
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To systematically review the literature regarding clinical outcomes of 180-W XPS GreenLight laser (GL) vaporisation for the treatment of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). METHODS:Recent publications were identified in the field of 180-W GL vaporisation for the...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12955
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To analyse the technical details and the long-term results of laparoscopic ureterolithotomy. PATIENTS AND METHODS:Laparoscopic ureterolithotomy was undertaken in 101 patients between 1991 and 2001; in only one patient with retroperitoneal fibrous adhesions was the procedure transperitoneal, being retroperito...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01562.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To validate a hypothesis that prostate cancer can be detected non-invasively by a simple and reliable assay by targeting genomic VPAC receptors expressed on malignant prostate cancer cells shed in voided urine. PATIENTS/SUBJECTS AND METHODS:VPAC receptors were targeted with a specific biomolecule, TP4303, de...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13775
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence of lower urinary tract symptoms (LUTS) and urinary incontinence (UI) in Canada, using a cross-Canada telephone survey, as there is a wide discrepancy in the reported prevalence of these conditions. SUBJECTS AND METHODS:A random survey with a standardized questionnaire was conducte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07198.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To describe and evaluate the outcomes of a new epididymovasostomy technique. PATIENTS AND METHODS:Nine patients with obstructive azoospermia were treated at the Minia University Hospital using a new microsurgical bilateral epididymovasostomy technique. The technique involved the opening of a small window in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12839
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between symptom severity and patient perceptions in patients with overactive bladder (OAB), as estimated by OAB Symptom Score (OABSS) and patient-reported outcome measures, respectively. PATIENTS AND METHODS:Post-hoc analyses were conducted on the existing data from patients with O...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08498.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary di...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14861
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To measure the time and subjective quality of individual steps of robot-assisted radical prostatectomy (RARP), as RARP performed by trainees has recently become the most common technique of RP in the USA, and although outcomes from expert surgeons are reported, limited data are available to document training ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08997.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:To determine whether conformity to standard recommendations of retroperitoneal lymph node dissection (RPLND) after chemotherapy for testicular and primary retroperitoneal nonseminomatous germ cell tumours (NSGCT) and completeness of surgical excision have an effect on oncological outcome. PATIENTS AND METHOD...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09175.x
更新日期:2010-09-01 00:00:00
abstract::What is known on the subject? and What does the study add? Substantial experience of the outcomes has been gathered regarding the acute and sub-acute experience with various types of corrective procedures for POP. These include long-term POP correction as well as more recent recognition of improvement in functional di...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10123.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14385
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice. PATIENTS AND METHODS:Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12458
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To study age- and sex-specific use and costs of incontinence aids distributed free of charge in Sweden. SUBJECTS AND METHODS:The study was conducted in the county of Jämtland, Sweden (132,000 inhabitants). The use and cost of incontinence aids for people living in their homes and the total cost of incontinen...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01429.x
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between International Continence Society categories of lower urinary tract symptoms (LUTS; storage, voiding, and postmicturition) and individual LUTS (associated with decreased sexual activity and sexual satisfaction in men) with erectile dysfunction (ED), ejaculatory dysfunction (...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08447.x
更新日期:2009-04-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Extracorporeal shockwave lithotripsy is effective for the treatment of paediatric renal stones with favourable short-term safety. Extracorporeal shockwave lithotripsy for treatment of paediatric renal stones is also safe for the kidney and the child ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11420.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of solitary rib lesions on pre-treatment 68 Gallium-labelled prostate-specific membrane antigen (PSMA)/computed tomography (CT) scans in men with prostate cancer that are malignant and examine any predictive factors. PATIENTS AND METHODS:This retrospective single tertiary referra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15152
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To identify an appropriate risk stratification system for intermediate-risk prostate cancer (PCa). PATIENTS AND METHODS:We reviewed the data on 1559 patients who were treated with radical prostatectomy (RP) at our institution between 2005 and 2013 and classified them according to National Comprehensive Cance...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12703
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11137.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:• To systematically review and compare the economic burden of open radical cystectomy (ORC) vs robot-assisted laparoscopic radical cystectomy (RALRC) with pelvic lymph node dissection and urinary diversion. PATIENTS AND METHODS:• A Medline search was conducted to identify English language articles regarding ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10468.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To assess the expression of the tumour markers stromelysin 3, MUC1, p53 and cytokeratin-7 in papillary renal cell carcinoma (pRCC, for which two histological subtypes are distinguished, i.e. type 1 and type 2, the latter appearing to be associated with a poorer prognosis) and to determine whether any of these...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07605.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To determine if cells expressing prostate-specific antigen (PSA) can be detected in blood collected by a cell-saver during radical prostatectomy (RP) or in the peripheral blood after intraoperative autotransfusion (IAT). PATIENTS AND METHODS:In all, 112 men with clinical T1c-T2 prostate cancer undergoing RP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05621.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00