Abstract:
OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary diversion (UD) for bladder cancer at our Institution were prospectively analysed. Patients who simultaneously demonstrated negative soft tissue surgical margins (STSMs), ≥16 lymph node (LN) yield, absence of major (grade III-IV) complications at 90 days, absence of UD-related long-term sequelae and absence of clinical recurrence at ≤12 months, were considered as having achieved the RC-pentafecta. A multivariable logistic regression model was assessed to measure predictors for achieving RC-pentafecta. RESULTS AND LIMITATIONS:Since 2010, 270 of 277 patients that had completed at least 12 months of follow-up were included. Over a mean follow-up of 22.3 months, ≥16 LN yield, negative STSMs, absence of major complications at 90 days, and absence of UD-related surgical sequelae and clinical recurrence at ≤12 months were observed in 93.0%, 98.9%, 76.7%, 81.5% and 92.2%, patients, respectively, resulting in a RC-pentafecta rate of 53.3%. Multivariable logistic regression analysis revealed age (odds ratio [OR] 0.95; P = 0.002), type of UD (OR 2.19; P = 0.01) and pN stage (OR 0.48; P = 0.03) as independent predictors for achieving RC-pentafecta. CONCLUSIONS:We present a RC-pentafecta as a standardisable composite endpoint that incorporates perioperative morbidity and oncological adequacy as a potential tool to assess quality of RC. This tool may be useful for assessing the learning curve and calculating cost-effectiveness amongst others but needs to be externally validated in future studies.
journal_name
BJU Intjournal_title
BJU internationalauthors
Cacciamani GE,Winter M,Medina LG,Ashrafi AN,Miranda G,Tafuri A,Landsberger H,Lin-Brande M,Rajarubendra N,De Castro Abreu A,Berger A,Aron M,Gill IS,Desai MMdoi
10.1111/bju.14861subject
Has Abstractpub_date
2020-01-01 00:00:00pages
64-72issue
1eissn
1464-4096issn
1464-410Xjournal_volume
125pub_type
杂志文章abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....
journal_title:BJU international
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doi:10.1111/j.1464-410X.2009.08984.x
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journal_title:BJU international
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abstract:OBJECTIVE:To assess in detail and evaluate the effect on survival of delays in the diagnosis and treatment of cancer (which might lead to a worse prognosis), dividing the delay from onset of symptoms to first treatment into several components, comprising patient delay, general practitioner (GP) delay, and two or more p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02776.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of OnabotulinumtoxinA (BTXA) injections in men with drug-refractory non-neurogenic overactive bladder (NNOAB). PATIENTS AND METHODS:A total of 43 men received BTXA injections for NNOAB from 2004 to 2012. Patient Global Impression of Improvement (PGI-I) score was obtained. For men with ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13110
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07129.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
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doi:10.1111/bju.12732
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journal_title:BJU international
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doi:10.1111/j.1464-410X.2007.07119.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:• To study the association between specific clinical symptoms (e.g. low libido and erectile dysfunction) and testosterone levels and age in order to define symptom-specific testosterone thresholds. MATERIALS AND METHODS:• Serum samples for testosterone determination were obtained from 675 healthy men. • Part...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09986.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14387
更新日期:2018-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2001.00100.x
更新日期:2001-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07158.x
更新日期:2007-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08562.x
更新日期:2009-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10283.x
更新日期:2012-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11205.x
更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410x.2000.tb16953.x
更新日期:2000-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07789.x
更新日期:2008-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11297.x
更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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更新日期:2004-01-01 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
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更新日期:2020-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-4096.2001.01817.x
更新日期:2002-02-01 00:00:00
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更新日期:2020-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13854
更新日期:2017-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12887
更新日期:2015-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05956.x
更新日期:2006-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05522.x
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/bju.12558
更新日期:2014-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11042.x
更新日期:2012-04-01 00:00:00