Abstract:
OBJECTIVE:To evaluate the efficacy of oxidized cellulose, Surgicel(TM) (Johnson & Johnson Medical, New Brunswick, NJ, USA) for patching defects in the tunica albuginea in a rabbit model, with a future application to correct chordee. MATERIALS AND METHODS:The study comprised nine New Zealand white male rabbits; a rectangular 15 x 5-mm defect was created in the ventral tunica albuginea that was covered by Surgicel. The skin was closed with no catheters left in situ after the procedure. The rabbits were killed in groups of three at 2, 6 and 12 weeks after surgery. The evaluation included cavernosography and histopathological examination of sections of the penis stained with haematoxylin and eosin, and Masson's trichrome. RESULTS:No deaths were caused by the procedure, and none of the rabbits developed bleeding or haematoma after surgery. Cavernosography at 2 weeks showed contrast medium leaking from the site of the Surgicel, but at 6 and 12 weeks all rabbits had a straight erection with patent corpora and no evidence of narrowing or venous leak. Histopathological evaluation revealed evidence of the remnants of Surgicel surrounded by acute inflammatory cell infiltrate with early neovascularization at 2 weeks. At 6 and 12 weeks, there was complete normal regeneration of the tunica albuginea with no foreign-body reaction. CONCLUSIONS:In this pilot study, Surgicel had a clear haemostatic effect when covering a defect in the tunica albuginea. Moreover, normal tunica albuginea regenerated by 6 weeks and was maintained at 12 weeks. These results suggest that Surgicel might be considered a safe and effective grafting material for tunica albuginea substitution, including the surgical management of penile chordee.
journal_name
BJU Intjournal_title
BJU internationalauthors
El-Assmy A,Eassa W,El-Hamid MA,Nour EM,Hafez ATdoi
10.1111/j.1464-410X.2006.06684.xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
1098-102issue
5eissn
1464-4096issn
1464-410Xpii
BJU6684journal_volume
99pub_type
杂志文章abstract:OBJECTIVE:• To investigate the role of c-kit-positive interstitial cells (ICCs) in mediating muscarinic receptor-induced phasic contractions of isolated bladder strips from streptozotocin(STZ)-induced diabetic rats and to confirm the expression and location of ICCs in the rat bladder. MATERIALS AND METHODS:• Bladders ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09507.x
更新日期:2011-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12955
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journal_title:BJU international
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To describe the pattern and prevalence of lower urinary tract symptoms (LUTS) and related help-seeking behaviour in men of South Asian origin living in the UK, and to compare this to the white population. SUBJECTS AND METHODS:Data were obtained as part of the Leicestershire MRC Incontinence Study. Community-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06377.x
更新日期:2006-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06678.x
更新日期:2007-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:BJU international
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journal_title:BJU international
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doi:10.1111/j.1464-410X.2012.11735.x
更新日期:2013-08-01 00:00:00
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更新日期:2016-09-01 00:00:00
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更新日期:2002-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06478.x
更新日期:2006-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2008.07845.x
更新日期:2008-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04854.x
更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08012.x
更新日期:2009-02-01 00:00:00
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doi:10.1111/j.1464-410X.2008.07558.x
更新日期:2008-08-01 00:00:00