Abstract:
OBJECTIVE:To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. PATIENTS AND METHODS:We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiary hospital between July 1981 and July 2010 who developed PSA recurrence (≥0.2 ng/mL) and never received adjuvant or salvage therapy before the development of metastatic disease. We estimated MFS using the Kaplan-Meier method, and investigated factors influencing the risk of metastasis using Cox proportional hazards regression. RESULTS:Median follow-up after prostatectomy was 8.0 years, and after biochemical recurrence was 4.0 years. At last follow-up, 134 of 450 patients (29.8%) had developed metastases, while median MFS was 10.0 years. Using multivariable regressions, two variables emerged as independently predictive of MFS: PSA doubling time (<3.0 vs 3.0-8.9 vs 9.0-14.9 vs ≥15.0 months) and Gleason score (≤6 vs 7 vs 8-10). Using these stratifications of Gleason score and PSA doubling time, tables were constructed to predict median, 5- and 10-year MFS after PSA recurrence. In different patient subsets, median MFS ranged from 1 to 15 years. CONCLUSIONS:In men undergoing prostatectomy, MFS after PSA recurrence is variable and is most strongly influenced by PSA doubling time and Gleason score. These parameters serve to stratify men into different risk groups with respect to metastatic progression. Our findings may provide the background for appropriate selection of patients, treatments and endpoints for clinical trials.
journal_name
BJU Intjournal_title
BJU internationalauthors
Antonarakis ES,Feng Z,Trock BJ,Humphreys EB,Carducci MA,Partin AW,Walsh PC,Eisenberger MAdoi
10.1111/j.1464-410X.2011.10422.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
32-9issue
1eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
杂志文章abstract:OBJECTIVE:To quantify in absolute terms the potential benefit of regionalisation of care from low- to high-volume hospitals. PATIENTS AND METHODS:Patients with a primary diagnosis of bladder cancer treated with radical cystectomy (RC) were identified within the Nationwide Inpatient Sample, a retrospective observationa...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVES:To describe the most recent data from phase I and II clinical trials of stereotactic body radiation therapy (SBRT) using image-guided robotic radiosurgery, specifically the Cyberknife(®) (Accuracy Incorporated, Sunnyvale, CA, USA). To better determine thecurrent role of this type of radiosurgery in prostate ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12000
更新日期:2013-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07435.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10968.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical outcome of extracorporeal shock-wave therapy (ESWT) for patients suffering from chronic pelvic pain syndrome (CPPS). PATIENTS AND METHODS:The study included 34 patients who had had CPPS for >or=3 months, who were investigated in two subsequent studies. ESWT was adm...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07742.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To evaluate partial nephrectomy (PN) use in patients at higher risk for clinical progression, using a large national database of American patients. PATIENTS AND METHODS:We performed a retrospective review of patients with cN0/cM0 renal cell carcinoma from 2003 to 2011 using the National Cancer Data Base. Ou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13262
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To analyse functional outcomes and complication rates of artificial urinary sphincter (AUS) implantation with a distal bulbar double cuff (DC) for the treatment of stress urinary incontinence (SUI) in men with and without a history of external beam radiotherapy (RT). PATIENTS AND METHODS:Data of all patient...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14882
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To review patients who had vesico-ureteric reflux corrected surgically by ureteric reimplantation during childhood, and thus assess their long-term outcome. PATIENTS AND METHODS:Between 1970 and 1979, 322 children underwent ureteric reimplantation; 100 (79 women and 21 men) were re-assessed and the long-term...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04264.x
更新日期:2003-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04882.x
更新日期:2004-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02881.x
更新日期:2002-08-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does the study add? Men with prostate cancer have higher rates of non-cancer mortality and CV morbidity and some of that excess risk has been attributed to the treatment they receive. ADT is an established treatment option ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10555.x
更新日期:2012-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09184.x
更新日期:2010-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15250
更新日期:2020-09-23 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05729.x
更新日期:2005-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00279.x
更新日期:1999-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00625.x
更新日期:2000-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05173.x
更新日期:2004-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09211.x
更新日期:2010-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11478.x
更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2003.04477.x
更新日期:2003-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07198.x
更新日期:2008-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14385
更新日期:2018-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04060.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2008.08040.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To compare the effects of diuresis induced by a loop diuretic (frusemide), an osmotic diuretic (mannitol) and a high-osmolar radio-contrast medium (sodium iothalamate) on the intrarenal resistive index (RI) in dogs with chronic unilateral partial ureteric obstruction (UPUO). MATERIALS AND METHODS:The split r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02830.x
更新日期:2002-07-01 00:00:00