Abstract:
OBJECTIVES:To determine the clinical utility of blood tests as a screening tool for metabolic abnormalities in patients with kidney stone disease. SUBJECTS AND METHODS:Clinical and biochemical data from 709 patients attending the Oxford University Hospitals NHS Foundation Trust for assessment and treatment of kidney stones were prospectively collected between April 2011 and February 2017. Data were analysed to determine the utility of serum calcium, parathyroid hormone (PTH), urate, chloride, bicarbonate, potassium and phosphate assays in screening for primary hyperparathyroidism, normocalcaemic hyperparathyroidism, hyperuricosuria, distal renal tubular acidosis (dRTA) and hypercalciuria. RESULTS:An elevated serum calcium level was detected in 2.3% of patients. Further investigations prompted by this finding resulted in a diagnosis of primary hyperparathyroidism in 0.2% of men and 4.6% of women for whom serum calcium was recorded. An elevated serum PTH level in the absence of hypercalcaemia was detected in 15.1% of patients. Of these patients, 74.6% were vitamin D-insufficient; no patients were diagnosed with normocalcaemic hyperparathyroidism. Hyperuricosuria was present in 21.6% of patients and hypercalciuria in 47.1%. Hyperuricaemia was not associated with hyperuricosuria, nor was hypophosphataemia associated with hypercalciuria. No patient was highlighted as being at risk of dRTA using serum chloride and bicarbonate as screening tests. CONCLUSION:This study indicates that individuals presenting with renal calculi should undergo metabolic screening with a serum calcium measurement alone. Use of additional blood tests to screen for metabolic disorders is not cost-effective and may provide false reassurance that metabolic abnormalities are not present. A full metabolic assessment with 24-h urine collection should be undertaken in recurrent stone formers and in those at high risk of future stone disease to identify potentially treatable metabolic abnormalities.
journal_name
BJU Intjournal_title
BJU internationalauthors
Eyre KS,Lewis F,Cui H,Grout E,Mihai R,Turney BW,Howles SAdoi
10.1111/bju.15250subject
Has Abstractpub_date
2020-09-23 00:00:00eissn
1464-4096issn
1464-410Xpub_type
杂志文章abstract:OBJECTIVE:To investigate cell division cycle 91-like 1 (CDC91L1; also called phosphatidylinositol glycan class U, PIG-U) expression in bladder cancer at both the mRNA and protein levels, and to study its clinical and prognostic significance, as CDC91L1 was recently identified as a new oncogene in human bladder cancer a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07192.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To study the role of peroperative transrectal ultrasonography (peTRUS) for the dissection of the bladder neck during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Integrated peTRUS in the da Vinci S system (Intuitive Surgical, Sunnyvale, CA, USA) was used for bladder neck identificat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07830.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of the application of autologous myoblasts and fibroblasts for treating female stress urinary incontinence (SUI) after a follow-up of >/=1 year. PATIENTS AND METHODS:In all, 123 women with SUI (aged 36-84 years) were treated with transurethral ultrasonography-guided injectio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07119.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To assess, in a retrospective study, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and the combination of both in unilateral clinical T3a (cT3a) prostate cancer. PATIENTS AND METHODS:Th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06452.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To assess the impact on patterns of recurrence of adjuvant chemotherapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) of the testis, who have a high likelihood of relapse on surveillance if certain risk factors are identified in the orchidectomy specimen, and thus the theoretical need for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00722.x
更新日期:2000-07-01 00:00:00
abstract::Data from the Japanese Urological Society showed that, in Japan, almost half of patients with localized prostate cancer are treated with hormone therapy (HT), regardless of disease stage, and that radiation therapy (RT) is also widely used to treat high-risk patients. A retrospective study was undertaken in Japan to e...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.06592.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To investigate histopathologically the beneficial effects of Panax ginseng extract on guinea pig testes damaged by 2,3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD). MATERIALS AND METHODS:Ninety guinea pigs were divided into six equal groups. The normal controls (group 1) received vehicle and saline; group 2 rece...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00046.x
更新日期:1999-05-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (outcomes) Level of Evidence 2a. What's known on the subject? and What does the study add? Erectile dysfunction (ED) is a well known implication of radical prostatectomy (RP). Despite the search for technical improvement in the surgical procedure (e.g. nerve-sparing surgery, robot-assiste...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11484.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.10371.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To determine whether heat, used in transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia and which causes necrotic lesions within the adenoma, induces apoptosis in benign human prostatic stromal cells. Materials and methods Prostatic stromal cells were cultured from benign human prosta...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00473.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To investigate the potential role of platelet-derived growth factor-AA (PDGF-AA) and the PDGF-α receptor as prognostic markers in Wilms' tumour. PATIENTS AND METHODS:The expression of PDGF-AA and PDGF-α were investigated using immunohistochemical analysis of 62 Wilms' tumours. Patients were treated with chem...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09211.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14894
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14385
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14455
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To explore the meaning that men attach to their experiences of having lower urinary tract symptoms (LUTS) and to understand 'bother' in the context of those meanings. PATIENTS AND METHODS:Sixteen men with symptoms suggestive of LUTS and/or an enlarged prostate were recruited from the outpatient urology clini...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05720.x
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12549
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12517
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. MATERIALS AND METHODS:Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8 weeks; gr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08261.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of demographic, clinical, treatment and patient-reported parameters on satisfaction with prostate cancer care. Despite the significant worldwide impact of prostate cancer, few data are available specifically addressing satisfaction with treatment-related care. PATIENTS AND METHODS:CaPS...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11423.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To optimise the diagnostic and phototherapeutic efficacy of hypericin in superficial bladder cancer, by developing a bladder instillation fluid that does not depend on the presence of plasma proteins for an appropriate and reliable urothelial uptake of hypericin. MATERIALS AND METHODS:Sodium hypericinate (in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05316.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:• To evaluate whether current nephrectomy pathology reports are sufficient to allow clinicians to use prognostic nomograms, tailor surveillance, enroll patients into adjuvant trials and select systemic therapy for renal cell carcinoma (RCC). PATIENTS AND METHODS:• Nephrectomy pathology reports were obtained ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09871.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of commercially available single-layer small intestinal submucosa (SIS) for urethral replacement, both as an onlay and as a tube, in a rabbit model. MATERIALS AND METHODS:Thirty-six male rabbits were assigned to four experimental groups. Group 1 had the ventral wall of the penile urethra ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05115.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To develop and validate an in vitro method suitable for the quantitative investigation of the growth of calcium oxalate stones through to a clinically significant size. MATERIALS AND METHODS:Small fragments of calcium oxalate calculi were suspended in a mixed suspension/mixed product removal crystalliser sup...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03027.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the relative merits of robotically assisted partial nephrectomy (RPN), using a matched-pair analysis, with laparoscopic PN (LPN). PATIENTS AND METHODS:Between July 2006 and August 2007, 12 patients had RPN for tumour; the outcomes were compared retrospectively with 12 matched patients who had LP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07580.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10315.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate long-term recurrence-free and progression-free survival of noninvasive bladder tumours (stage Ta), and the significance of simple risk factors, including concomitant epithelial dysplasia. PATIENTS AND METHODS:The study included 217 patients with primary noninvasive bladder tumour (stage Ta) who w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00547.x
更新日期:2000-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The clinical presentation and complications of lichen sclerosus are well known. What is less well known is the true incidence of the condition. The published figures are all based on attendance at general medical clinics or specialist clinics, but it ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10699.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To assess the changing distribution of stage in seminoma and nonseminomatous germ cell tumours (NSGCTs), as recent reports contained no detailed information on pT stage and vascular invasion, important factors in the decision for further treatment. PATIENTS AND METHODS:Histopathological reports from 1976 to ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06424.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To describe and assess the evolution of an enhanced recovery programme (ERP) for open radical cystectomy. PATIENTS AND METHODS:We introduced a mentored ERP for radical cystectomy in January 2011. The programme underwent service evaluation and multiple changes in August 2012 that we define as marginal gains. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12644
更新日期:2014-09-01 00:00:00