Detrusor glycogen reflects the functional history of bladders with partial outlet obstruction.

Abstract:

OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control group had a sham operation for comparison. Longitudinal individual urodynamic data were obtained weekly, so that guinea pigs were killed at different levels of bladder dysfunction. Bladder sections were stained with periodic acid-Schiff (PAS) to assess overall morphology and glycogen granule density, scored from 0 (no glycogen) to 3. Glycogen scores were related to both the end-stage and historical extremes of bladder function values. RESULTS:Glycogen granules were seen only in the detrusor; as their number increased their location expanded from only close to the serosa (glycogen score 1), through the detrusor (score 2) up to the urothelium (score 3). A glycogen score of 0 correlated with normal values for all urodynamic variables. Compared with a glycogen score of 0 a score of 1 correlated with significant (P < 0.05) changes in end-stage compliance (decrease) and contractility (increase) and significantly higher historical values for contractility, pressure and number of unstable contractions (NUC). In the group with a glycogen score of 2 there were significant changes in both the end-stage values and historical extremes for compliance, pressure, contractility and NUC (all P < 0.05). In the group with a glycogen score of 3 all these changes were even more dramatic, except for the end-stage contractility, for which the increase was not significant. From glycogen score 0 to score 3 all changes increased in magnitude. CONCLUSION:A high glycogen content reflects a history of abnormal urodynamic function. This finding exemplifies the added value of structural analysis to urodynamic studies. Further studies are needed to relate bladder structure to the potential for functional recovery.

journal_name

BJU Int

journal_title

BJU international

authors

de Jong BW,Wolffenbuttel KP,Arentshorst ME,Lodder P,Kok DJ

doi

10.1111/j.1464-410X.2007.07046.x

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

846-52

issue

4

eissn

1464-4096

issn

1464-410X

pii

BJU7046

journal_volume

100

pub_type

杂志文章
  • Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancy.

    abstract:OBJECTIVE:To report experience with a minimally invasive technique for palliation of urinary fistula/incontinence complicating advanced pelvic malignancy or its treatment. PATIENTS AND METHODS:We used ureteric embolization with permanent nephrostomy drainage in eight renal units in five patients for palliation of symp...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06522.x

    authors: Natarajan V,Boucher NR,Meiring P,Spencer P,Parys BT,Oakley NE,Stent (Society for Endourology in North Trent) Group.

    更新日期:2007-01-01 00:00:00

  • Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.

    abstract:OBJECTIVE:To determine the role of hypoxia-inducible factor-2alpha (HIF2alpha) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2alpha protein levels. MATERIALS AND METHODS:Cell lines expressing stable short-hairpin ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07558.x

    authors: Bhatt RS,Landis DM,Zimmer M,Torregrossa J,Chen S,Sukhatme VP,Iliopoulos O,Balk S,Bubley GJ

    更新日期:2008-08-01 00:00:00

  • Bladder calculi in children who perform clean intermittent catheterization.

    abstract:OBJECTIVE:To examine the role of clean intermittent catheterization (CIC) as a possible predisposing risk factor for bladder calculi, assessing risk factors in patients with and without bladder augmentation, and to evaluate management options for bladder calculi in these patients. PATIENTS AND METHODS:The records of 4...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00625.x

    authors: Barroso U,Jednak R,Fleming P,Barthold JS,González R

    更新日期:2000-05-01 00:00:00

  • Outcomes for patients with high-grade prostate cancer treated with a combination of brachytherapy, external beam radiotherapy and hormonal therapy.

    abstract:OBJECTIVE:To assess the outcomes for patients with Gleason score 8-10 prostate cancer treated with brachytherapy, external beam radiotherapy (EBRT) and hormonal therapy (HT). PATIENTS AND METHODS:In all, 181 patients with Gleason scores 8-10 prostate cancer were treated from 1994 to 2006 with a (103)Pd implant (prescr...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08661.x

    authors: Stock RG,Cesaretti JA,Hall SJ,Stone NN

    更新日期:2009-12-01 00:00:00

  • Analysis of peripheral blood for prostate cells after autologous transfusion given during radical prostatectomy.

    abstract:OBJECTIVES:To determine if cells expressing prostate-specific antigen (PSA) can be detected in blood collected by a cell-saver during radical prostatectomy (RP) or in the peripheral blood after intraoperative autotransfusion (IAT). PATIENTS AND METHODS:In all, 112 men with clinical T1c-T2 prostate cancer undergoing RP...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05621.x

    authors: Stoffel JT,Topjian L,Libertino JA

    更新日期:2005-08-01 00:00:00

  • A novel midstream urine-collection device reduces contamination rates in urine cultures amongst women.

    abstract:OBJECTIVE:To evaluate a novel urine-collection device (UCD) that automatically collects a midstream urine (MSU) sample, and compare contamination rates to those of the conventional MSU sampling method, as the contamination of urine samples for microbiological analysis in women leads to diagnostic ambiguity and unnecess...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2005.05631.x

    authors: Jackson SR,Dryden M,Gillett P,Kearney P,Weatherall R

    更新日期:2005-08-01 00:00:00

  • Outcomes of living donor renal transplantation in children with lower urinary tract dysfunction: a comparative retrospective study.

    abstract:OBJECTIVES:To compare outcomes of renal transplantation (RTx) in children with end-stage renal disease (ESRD) resulting from lower urinary tract dysfunction (LUTD) vs other causes. PATIENTS AND METHODS:A database of children (<18 years old) who underwent RTx between May 2008 and April 2012 was reviewed. Patients were ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13347

    authors: Saad IR,Habib E,ElSheemy MS,Abdel-Hakim M,Sheba M,Mosleh A,Salah DM,Bazaraa H,Fadel FI,Morsi HA,Badawy H

    更新日期:2016-08-01 00:00:00

  • Trends in the surgical management of localized renal masses: thermal ablation, partial and radical nephrectomy in the USA, 1998-2008.

    abstract:OBJECTIVE:To evaluate the diffusion of nephron-sparing modalities (NSM) for the treatment of renal neoplasms in the USA over the last decade and to identify the factors associated with renal procedure selection. PATIENTS AND METHODS:The Nationwide Inpatient Sample was utlized to identify patients undergoing cryo/radio...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11497.x

    authors: Woldrich JM,Palazzi K,Stroup SP,Sur RL,Parsons JK,Chang D,Derweesh IH

    更新日期:2013-06-01 00:00:00

  • The effect of prostate weight on the outcomes of laparoscopic radical prostatectomy.

    abstract:OBJECTIVE:To evaluate the effect of prostate weight on perioperative, functional and oncological outcomes after laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:Between January 2003 and January 2006, 327 patients had LRP by one surgeon, 193 of whom were available for analysis. Patients were stratified in...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07263.x

    authors: Frota R,Turna B,Santos BM,Lin YC,Gill IS,Aron M

    更新日期:2008-03-01 00:00:00

  • Increased patient satisfaction from transrectal ultrasonography and biopsy under sedation.

    abstract:OBJECTIVE:To determine the acceptability and patient satisfaction of transrectal biopsy undertaken with the patient under sedation. Patients and methods A retrospective questionnaire was sent to 100 patients who had undergone transrectal biopsy between January and August 1998. Levels of patient acceptability and satisf...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02221.x

    authors: Peters JL,Thompson AC,McNicholas TA,Hines JE,Hanbury DC,Boustead GB

    更新日期:2001-06-01 00:00:00

  • Efficacy of tolterodine as a first-line treatment for non-neurogenic voiding dysfunction in children.

    abstract:OBJECTIVE:To assess the effect of antimuscarinic treatment with tolterodine combined with behavioural modification as a first-line treatment, before invasive investigation, in children with non-neurogenic voiding dysfunction but no obvious anatomical or neurogenic cause. PATIENTS AND METHODS:The study comprised 44 chi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05641.x

    authors: Ayan S,Kaya K,Topsakal K,Kilicarslan H,Gokce G,Gultekin Y

    更新日期:2005-08-01 00:00:00

  • Subcapsular renal haematoma after holmium:yttrium-aluminum-garnet laser ureterolithotripsy.

    abstract:OBJECTIVE:To report the incidence, risk factors, and outcomes of subcapsular renal haematoma (SRH) after ureteroscopic lithotripsy (URSL) using holmium:yttrium-aluminum-garnet (Ho:YAG) laser to treat ureteric stones. PATIENTS AND METHODS:Prospective data from 2848 URSLs performed between January 2003 and September 201...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10490.x

    authors: Bai J,Li C,Wang S,Liu J,Ye Z,Yu X,Xi Q,Ni M,He D

    更新日期:2012-04-01 00:00:00

  • Current applications of three-dimensional printing in urology.

    abstract::Three-dimensional (3D) printing or additive manufacturing is a new technology that has seen rapid development in recent years with decreasing costs. 3D printing allows the creation of customised, finely detailed constructs. Technological improvements, increased printer availability, decreasing costs, improved cell cul...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14928

    authors: Chen MY,Skewes J,Desselle M,Wong C,Woodruff MA,Dasgupta P,Rukin NJ

    更新日期:2020-01-01 00:00:00

  • Cancer ablation with regional templates applied to prostatectomy specimens from men who were eligible for focal therapy.

    abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08359.x

    authors: Ward JF,Nakanishi H,Pisters L,Babaian RJ,Troncoso P

    更新日期:2009-08-01 00:00:00

  • Performance comparison of two androgen receptor splice variant 7 (AR-V7) detection methods.

    abstract:OBJECTIVES:To compare the performance of two established androgen receptor splice variant 7 (AR-V7) mRNA detection systems, as paradoxical responses to next-generation androgen-deprivation therapy in AR-V7 mRNA-positive circulating tumour cells (CTC) of patients with castration-resistant prostate cancer (CRPC) could be...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14146

    authors: Bernemann C,Steinestel J,Humberg V,Bögemann M,Schrader AJ,Lennerz JK

    更新日期:2018-08-01 00:00:00

  • Urological litigation in the UK National Health Service (NHS): an analysis of 14 years of successful claims.

    abstract:OBJECTIVES:• To present a summary of the collected data on urological litigation within the UK National Health Service (NHS). • Knowledge of the main areas of litigation is essential for maintaining good clinical practice as well as risk management procedures in any specialty. MATERIALS AND METHODS:• Details of all cl...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2011.10130.x

    authors: Osman NI,Collins GN

    更新日期:2011-07-01 00:00:00

  • To determine whether the temperature of 2% lignocaine gel affects the initial discomfort which may be associated with its instillation into the male urethra.

    abstract:OBJECTIVE:To determine whether the temperature of 2% lignocaine hydrochloride gel affects the initial discomfort during instillation into the male urethra. PATIENTS AND METHODS:Sixty consenting men were randomized to receive 11 mL of 2% lignocaine hydrochloride gel (Instillagel, Farco-Pharma GmbH, Cologne, Germany) at...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.1999.00346.x

    authors: Thompson TJ,Thompson N,O'Brien A,Young MR,McCleane G

    更新日期:1999-12-01 00:00:00

  • How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study.

    abstract:OBJECTIVE:To determine the prevalence of chronic and debilitating symptoms of the overactive bladder, defined here as the presence of chronic frequency, urgency and urge incontinence (either alone or in any combination), and presumed to be caused by involuntary detrusor contractions. Subjects and methods Data were coll...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02228.x

    authors: Milsom I,Abrams P,Cardozo L,Roberts RG,Thüroff J,Wein AJ

    更新日期:2001-06-01 00:00:00

  • Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta-analysis.

    abstract::The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of pati...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/bju.14366

    authors: Gandhi N,Krishna S,Booth CM,Breau RH,Flood TA,Morgan SC,Schieda N,Salameh JP,McGrath TA,McInnes MDF

    更新日期:2018-11-01 00:00:00

  • Does the surgical technique for management of the distal ureter influence the outcome after nephroureterectomy?

    abstract::Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it represents a part of the urinary tract exposed to a consid...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2010.09835.x

    authors: Phé V,Cussenot O,Bitker MO,Rouprêt M

    更新日期:2011-07-01 00:00:00

  • Long-term follow-up of noninvasive bladder tumours (stage Ta): recurrence and progression.

    abstract:OBJECTIVE:To evaluate long-term recurrence-free and progression-free survival of noninvasive bladder tumours (stage Ta), and the significance of simple risk factors, including concomitant epithelial dysplasia. PATIENTS AND METHODS:The study included 217 patients with primary noninvasive bladder tumour (stage Ta) who w...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00547.x

    authors: Zieger K,Wolf H,Olsen PR,Hojgaard K

    更新日期:2000-05-01 00:00:00

  • Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: its association with pain severity and glomerulations.

    abstract:OBJECTIVE:To determine the angiogenic profiles in the bladder of patients with bladder pain syndrome (BPS)/interstitial cystitis (IC), and to evaluate the relationship between these profiles and associated clinical features including pelvic pain and glomerulations. PATIENTS AND METHODS:Angiogenesis and angiogenic comp...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08467.x

    authors: Kiuchi H,Tsujimura A,Takao T,Yamamoto K,Nakayama J,Miyagawa Y,Nonomura N,Takeyama M,Okuyama A

    更新日期:2009-09-01 00:00:00

  • Use of cyanoacrylate tissue adhesive under a diaper.

    abstract:OBJECTIVE:To examine the utility of cyanoacrylate tissue adhesive (Dermabond, Ethicon, Somerville, NJ, USA; an effective means of epithelial skin closure) under a diaper (i.e. constantly exposed to bodily fluids) in 25 children (not toilet-trained) undergoing inguinal surgery. PATIENTS AND METHODS:A retrospective revi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02142.x

    authors: Ferlise VJ,Ankem MK,Barone JG

    更新日期:2001-05-01 00:00:00

  • Performance Improvement (Pi) score: an algorithm to score Pi objectively during E-BLUS hands-on training sessions. A European Association of Urology, Section of Uro-Technology (ESUT) project.

    abstract:OBJECTIVE:To evaluate the variability of subjective tutor performance improvement (Pi) assessment and to compare it with a novel measurement algorithm: the Pi score. MATERIALS AND METHODS:The Pi-score algorithm considers time measurement and number of errors from two different repetitions (first and fifth) of the same...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14621

    authors: Veneziano D,Canova A,Arnolds M,Beatty JD,Biyani CS,Dehò F,Fiori C,Hellawell GO,Langenhuijsen JF,Pini G,Rodriguez Faba O,Siena G,Skolarikos A,Tokas T,Van Cleynenbreugel BSEP,Wagner C,Tripepi G,Somani B,Lima B

    更新日期:2019-04-01 00:00:00

  • Vaporesection for managing benign prostatic hyperplasia using a 2-microm continuous-wave laser: a prospective trial with 1-year follow-up.

    abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1464-410X.2008.08040.x

    authors: Fu WJ,Hong BF,Yang Y,Zhang X,Gao JP,Zhang L,Wang XX

    更新日期:2009-02-01 00:00:00

  • Evaluation of a synchronous twin-pulse technique for shock wave lithotripsy: the first prospective clinical study.

    abstract:OBJECTIVE:To present the results of the first clinical study of a synchronous twin-pulse technique for extracorporeal shock-wave lithotripsy (ESWL), which is effective for in vitro stone fragmentation and safe when assessed in vivo on animal tissue. PATIENTS AND METHODS:Fifty patients with urinary stones (35 men and 1...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1464-410X.2005.05306.x

    authors: Sheir KZ,El-Diasty TA,Ismail AM

    更新日期:2005-02-01 00:00:00

  • Prognostic value of the Gleason score in prostate cancer.

    abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02669.x

    authors: Egevad L,Granfors T,Karlberg L,Bergh A,Stattin P

    更新日期:2002-04-01 00:00:00

  • A magnetic resonance imaging-based study of retropubic haematoma after sling procedures: preliminary findings.

    abstract:OBJECTIVE:To determine, using magnetic resonance imaging (MRI), the incidence of retropubic haematoma and any associated clinically significant effects after a xenograft (porcine dermis) sling (XS) or the tension-free vaginal tape (TVT) procedure. PATIENTS AND METHODS:Between October 2003 and March 2004, 24 consecutiv...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05779.x

    authors: Giri SK,Wallis F,Drumm J,Saunders JA,Flood HD

    更新日期:2005-11-01 00:00:00

  • Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones.

    abstract:OBJECTIVE:To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS:The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09890.x

    authors: Safarinejad MR,Shafiei N,Safarinejad S

    更新日期:2011-07-01 00:00:00

  • Protein kinase C inhibitor prevents renal apoptotic and fibrotic changes in response to partial ureteric obstruction.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Protein kinase C inhibitor (PKCI) can decrease glomerular and tubular cell apoptosis and mitosis and attenuate collagen accumulation and fibronectin expression in a PUUO rat model. Although the role of PKC has been well studied in diabetic nephropathy...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10805.x

    authors: Juan YS,Chuang SM,Long CY,Lin RJ,Liu KM,Wu WJ,Huang CH

    更新日期:2012-07-01 00:00:00