Abstract:
OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIALS AND METHODS:Therapies for prostate cancer hold the promise of individualized treatment that selectively ablates the tumour while minimizing treatment-associated morbidity, but as prostate cancer is multifocal there are concerns about untreated residual disease. RP specimens (180) from men with a unilaterally positive prostate biopsy were examined to characterize the location, volume and grade of each tumour focus. Two treatment templates (hemiprostate and 'hockey-stick') were applied to every prostate cross-section. The nature of the in-field and out-of-field tumours was assessed and described for each treatment template. RESULTS:A single focus of cancer was the only tumour in 31 (17%) of the patients (contralateral cancer was present in 149, 83%, of specimens despite a unilateral positive biopsy). Hemiprostate and hockey-stick treatment templates covered all tumour foci in 17% and 47% of men, respectively. Most out-of-field cancers were clinically insignificant tumours not identified by prostate biopsy (low-volume, 0.5 mL; and low grade, Gleason score < or =6). Regional ablation would have successfully treated all clinically significant prostate tumours in 64% and 81% of patients using the hemiprostate or hockey-stick template, respectively. The hockey-stick template encompassed all dominant tumours (largest volume). CONCLUSIONS:Regionally targeted prostate ablation is capable of eradicating all dominant tumours and the vast majority of clinically significant tumours in men with unilateral disease by biopsy. The study of focally ablative therapy should proceed under the auspices of an approved protocol.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ward JF,Nakanishi H,Pisters L,Babaian RJ,Troncoso Pdoi
10.1111/j.1464-410X.2009.08359.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
490-7issue
4eissn
1464-4096issn
1464-410Xpii
BJU8359journal_volume
104pub_type
杂志文章abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To report a simplified and effective method for substratification of M1 castrate-resistant prostate cancer (CRPC) by correlating progression-free (PFS) and overall survival (OS) with simple quantification of skeletal metastases. PATIENTS AND METHODS:In all, 561 men with M1 CRPC were studied longitudinally. I...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12717
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To study the role of peroperative transrectal ultrasonography (peTRUS) for the dissection of the bladder neck during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Integrated peTRUS in the da Vinci S system (Intuitive Surgical, Sunnyvale, CA, USA) was used for bladder neck identificat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07830.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To compare in vivo the potency and bladder-vascular selectivity of ATP-sensitive potassium channel openers (KCOs) (-)-cromakalim, WAY-133537 and ZD6169 and a muscarinic antagonist, tolterodine in rats. MATERIALS AND METHODS:Bladder and arterial pressures were monitored simultaneously, before and after increa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03069.x
更新日期:2003-02-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: In renal cell carcinoma the role of lymphadenectomy (LND) is still controversial. Moreover, no firm consensus exists regarding the minimum number of lymph nodes that should be removed to obtain a satisfactory staging LND at the time of surgery. Our f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11313.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. PATIENTS AND METHODS:Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tula...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.09042.x
更新日期:2010-06-01 00:00:00
abstract::Detrusor sphincter dyssynergia (DSD) is variant of neurogenic bladder dysfunction caused by suprasacral neurological abnormalities and may be associated with serious complications if unrecognised. This paper focuses on the clinical features as well as challenges and limitations in the diagnosis of DSD. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11042.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoper...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.15105
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in bone mass and fracture risk in patients with prostate cancer on androgen-deprivation therapy (ADT) and with a basal T-score of >-2.0, who were treated with an oral bisphosphonate, as such patients treated with ADT are at increased risk of bone loss and bone fracture. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08622.x
更新日期:2009-12-01 00:00:00
abstract::The aims of the present review were to assess the literature on published outcomes and complications associated with surgical treatments for Peyronie's disease (PD) and to assist clinicians in the effective management of PD by increasing understanding and awareness of the outcomes associated with current surgical trea...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12565
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that bladder cancer is a heterogeneous disease. PATIENTS AND METHODS:We examined the temporal trends of bladder cancer by histological subtype and by disease stage and grade using the National Cancer Institute's Surveillance, Epidemiology, and End Results data collected in 1973-2007. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10283.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To estimate the population-based conditional 5-year relative survival rates for patients with prostate cancer (PCa). PATIENTS AND METHODS:All 98 672 patients, aged 45-89 years, diagnosed in the Netherlands with PCa (clinical T stage 1-4) in the period 1989-2008 were selected from the Netherlands Cancer Regis...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12519
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To analyse telomerase activity in disseminated prostate cancer cells isolated from bone marrow aspirates taken from men with localized prostate cancer before radical prostatectomy (RP). PATIENTS AND METHODS:Disseminated epithelial prostate cancer cells were isolated from bone marrow aspirates from 69 men wit...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06194.x
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To investigate the immunology of host-tumour interaction, critical for the development of immunotherapy against cancers, by assessing the major histocompatibility complex (MHC) class I expression in both benign and malignant prostate disease, and the relationship between their expression and degree of tumour-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02993.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To assess the impact on patterns of recurrence of adjuvant chemotherapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) of the testis, who have a high likelihood of relapse on surveillance if certain risk factors are identified in the orchidectomy specimen, and thus the theoretical need for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00722.x
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To analyse our long-term oncological outcomes with active surveillance in patients with positive surgical margins (PSMs) after nephron-sparing surgery (NSS) for renal cell carcinoma (RCC), as this situation is a difficult therapeutic dilemma. PATIENTS AND METHODS:We performed open NSS for renal masses with f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09174.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To assess fibroblast growth factor-2 (FGF2/bFGF), which is important in the development and maintenance of the normal prostate and in the development of human benign prostatic hyperplasia (BPH) and prostatic carcinoma, in an animal model of experimentally induced diabetes. Materials and methods Using Western ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00597.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the therapeutic potential of sympatholytic agents on premature ejaculation in an animal model, using monitoring of rat seminal vesicle pressure change in response to electrical stimulation of the lesser splanchnic nerve. MATERIALS AND METHODS:Male Wistar rats (aged 12-14 weeks) were injected intr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00173.x
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:To compare the effects of taking tadalafil 5 mg and placebo once daily on post-micturition dribble (PMD) in men with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS:Our prospective, randomized, double-blind, placebo-controlled, multicentre trial enrolled 102 men with PMD and other LUTS. PMD was as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14849
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To assess the clinical effect of the 'prostatic urethral lift' (PUL) on lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) through a crossover design study. PATIENTS AND METHODS:Men aged ≥ 50 years with an International Prostate Symptom Score of ≥ 13, a maximum urinary flo...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.12540
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To determine the metabolic characteristics of elderly patients with recurrent calcium oxalate stones. PATIENTS AND METHODS:Metabolic abnormalities were investigated in 88 patients with recurrent calcium oxalate stones, including 70 aged <60 years and 18 aged >/=60 years. The frequency of each metabolic abnor...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00057.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2008.08040.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To analyze pathological and short-term oncological outcomes in men undergoing open and minimally-invasive radical prostatectomy (MIRP) for high-risk prostate cancer (HRPC; prostate-specific antigen level [PSA] >20 ng/mL, ≥ cT2c, Gleason score 8-10) in a contemporaneous series. PATIENTS AND METHODS:In total,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11757.x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To present our experience and outcome of consecutive laparoscopic renal biopsy over a 9-year period, as renal biopsy remains an important diagnostic procedure for evaluating proteinuria, haematuria and renal failure, but when percutaneous biopsy is contraindicated, a laparoscopic biopsy is an attractive opti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04243.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). PATIENTS AND METHODS:Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Lo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07921.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12732
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of ureteroscopy plus intracorporeal lithotripsy (ULT) with extracorporeal shock wave lithotripsy (ESWL) for treating distal ureteric calculi in childhood, as such stones are commonly treated by ESWL as the first option in adults but there is no agreement on the method of tre...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2005.05464.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07068.x
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:To prospectively evaluate the accuracy of transvesical contrast-enhanced ultrasound (CEUS) as an alternative method for the detection of anastomotic leakage after radical retropubic prostatectomy (RRP) in comparison with the current standard method of conventional retrograde cystography (CG). PATIENTS AND...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09497.x
更新日期:2010-12-01 00:00:00