Prognostic factors for and outcome of locally advanced prostate cancer after radical prostatectomy.

Abstract:

OBJECTIVE:To present the outcomes of cT3N0M0 prostate cancer after radical prostatectomy (RP) and determine the prognostic factors in biochemical progression-free survival (BPFS), clinical progression-free survival (CPFS), cancer-specific survival (CSS) and overall survival (OS) after long-term follow-up of 10 years. PATIENTS AND METHODS:In all, 164 patients who were assessed as clinical T3 prostate cancer by digital rectal examination (DRE), underwent RP and bilateral pelvic lymphadenectomy at Erasmus MC between 1977 and 2004 without neoadjuvant treatment. Preoperative staging computed tomography showed no signs of metastasis. Kaplan-Meier curves were constructed to show BPFS, CPFS, CSS and OS. Cox proportional hazard analysis was used to determine prognostic indicators of disease progression. RESULTS:The mean (range) follow-up was 100 (1-291) months. At 5, 10 and 15 years, BPFS was 50.4%, 43.0% and 38.3%, respectively, CPFS was 79.7%, 68.7% and 63.5%, CSS was 93.4%, 80.3% and 66.3%, and OS was 87.1%, 67.2% and 37.4%. Multivariate Cox proportional hazard analysis showed that surgical tumour grade, margin and node status were significant factors in CPFS and CSS. Surgical tumour grade, node status and preoperative PSA level were significant factors in BPFS CONCLUSION: RP for clinically locally advanced prostate cancer may produce acceptable long-term BPFS, which is comparable with published results of radiotherapy with adjuvant endocrine therapy. Pathological tumour grade and node status were significant predicting factors in BPFS and CPFS, as well as tumour-specific survival after 100 months follow-up.

journal_name

BJU Int

journal_title

BJU international

authors

Hsu CY,Wildhagen MF,Van Poppel H,Bangma CH

doi

10.1111/j.1464-410X.2009.09054.x

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1536-40

issue

11

eissn

1464-4096

issn

1464-410X

pii

BJU9054

journal_volume

105

pub_type

杂志文章
  • Perioperative, functional and oncological outcomes after open and minimally invasive prostate cancer surgery: experience from Australasia.

    abstract:OBJECTIVE:•  To systematically review the current literature concerning perioperative, functional and oncological outcomes reported after open and minimally invasive prostate cancer surgery specifically from institutions within Australasia. MATERIALS AND METHODS:•  Four electronic databases were searched to identify s...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2011.10053.x

    authors: Cathcart P,Murphy DG,Moon D,Costello AJ,Frydenberg M

    更新日期:2011-04-01 00:00:00

  • Metoidioplasty: a variant of phalloplasty in female transsexuals.

    abstract:OBJECTIVE:To describe metoidioplasty, a technique for creating a neophallus from an enlarged clitoris in female transsexuals, without needing the complex, multi-staged surgical construction of a large phallus, as this reconstruction is one of the most difficult in female transsexuals. PATIENTS AND METHODS:From Septemb...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410x.2003.04524.x

    authors: Perovic SV,Djordjevic ML

    更新日期:2003-12-01 00:00:00

  • Arteries of the scrotum: a microvascular study and its application to urethral reconstruction with scrotal flaps.

    abstract:OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08167.x

    authors: Carrera A,Gil-Vernet A,Forcada P,Morro R,Llusa M,Arango O

    更新日期:2009-03-01 00:00:00

  • The relationship of ultrasensitive measurements of prostate-specific antigen levels to prostate cancer recurrence after radical prostatectomy.

    abstract:OBJECTIVE:To evaluate ultrasensitive (US) measurements of prostate-specific antigen (PSA) level in men with prostate cancer, and to correlate the findings with currently accepted values for PSA recurrence, as PSA is widely accepted as a surrogate marker for disease recurrence after treatment for prostate cancer, and al...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06294.x

    authors: Taylor JA 3rd,Koff SG,Dauser DA,McLeod DG

    更新日期:2006-09-01 00:00:00

  • Review article: Mid-urethral synthetic slings for female stress urinary incontinence.

    abstract::• Mid-urethral synthetic slings (MUSS) have grown in acceptance and popularity to gain a foremost position in stress urinary incontinence (SUI) surgery. • There are numerous studies that provide a large amount of Level 1 and 2 evidence that support the concept of a sling placed at the level of the mid-urethra. • Long-...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2010.09544.x

    authors: Fong ED,Nitti VW

    更新日期:2010-09-01 00:00:00

  • Technical and equipment challenges for laparoendoscopic single-site surgery and natural orifice transluminal endoscopic surgery.

    abstract::Laparoendoscopic single-site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES™) are new approaches to minimally invasive surgery. A number of technical challenges need to be overcome and new developments of equipment are required before widespread acceptance of either modality occurs. In this ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09665.x

    authors: Sawyer MD,Ponsky LE

    更新日期:2010-09-01 00:00:00

  • The role of targeted prophylactic antimicrobial therapy before transrectal ultrasonography-guided prostate biopsy in reducing infection rates: a systematic review.

    abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.13402

    authors: Cussans A,Somani BK,Basarab A,Dudderidge TJ

    更新日期:2016-05-01 00:00:00

  • The ability of the American Joint Committee on Cancer Staging system to predict progression-free survival after radical prostatectomy.

    abstract:OBJECTIVE:To examine, in a retrospective analysis of outcome based on prostate-specific antigen (PSA) levels, whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression-free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer. PATIENTS AND ME...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-4096.2001.02420.x

    authors: May F,Hartung R,Breul J

    更新日期:2001-11-01 00:00:00

  • Recovery of erectile function after radical prostatectomy is quantitatively related to the response to intraoperative cavernous nerve stimulation.

    abstract:OBJECTIVE:To correlate the results of intraoperative cavernous nerve stimulation (CaNS) at radical prostatectomy (RP), with preoperative erectile function (EF) and to determine the significance of the results of stimulation after RP in predicting the recovery of EF. PATIENTS AND METHODS:The study included 183 potent m...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08519.x

    authors: Rabbani F,Patel M,Cozzi P,Mulhall JP,Scardino PT

    更新日期:2009-11-01 00:00:00

  • TURP and sex: patient and partner prospective 12 years follow-up study.

    abstract:OBJECTIVE:• To evaluate the effect of transurethral resection of the prostate (TURP) on sexual function in the short (6 months), medium (6 years) and long (12 years) term and assess the conformity between patient and partner regarding sexual function. PATIENTS AND METHODS:• A prospective cohort study set at the Aberde...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10396.x

    authors: Mishriki SF,Grimsley SJ,Lam T,Nabi G,Cohen NP

    更新日期:2012-03-01 00:00:00

  • Five-year data from the Oxford Laser Prostatectomy Trial.

    abstract:OBJECTIVE:To evaluate the natural history of a group of patients who underwent contact laser prostatectomy or transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were followed up at 5 years after enrolling in a prospective double-blind randomized controlled trial of TURP vs contact laser pros...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00778.x

    authors: Keoghane SR,Sullivan ME,Doll HA,Kourambas J,Cranston DW

    更新日期:2000-08-01 00:00:00

  • Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine.

    abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04020.x

    authors: Nutt JE,Durkan GC,Mellon JK,Lunec J

    更新日期:2003-01-01 00:00:00

  • FK506-binding protein localizations in human penile innervation.

    abstract:OBJECTIVE:To determine if FK506-binding proteins (FKBPs) are localized to the autonomic nerve supply of the human penis because FK506 (an immunosuppressant drug) has been linked to enhanced nerve regeneration after nerve injury and neurodegenerative diseases by binding to FKBPs, a select group of immunophilins. MATERI...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07290.x

    authors: Lagoda G,Sezen SF,Liu T,Höke A,Burnett AL

    更新日期:2008-03-01 00:00:00

  • Salvage cystectomy after failure of interstitial radiotherapy and external beam radiotherapy for bladder cancer.

    abstract:OBJECTIVE:To evaluate the long-term results of salvage cystectomy after interstitial radiotherapy (IRT) and external beam radiotherapy (EBRT) for transitional cell carcinoma, and to assess the morbidity and functional results of the different urinary diversions used. PATIENTS AND METHODS:The records of 27 patients tre...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05034.x

    authors: Nieuwenhuijzen JA,Horenblas S,Meinhardt W,van Tinteren H,Moonen LM

    更新日期:2004-10-01 00:00:00

  • Improving the prognosis of patients after radical cystectomy. Part I: the role of lymph node dissection.

    abstract::The first two reviews are from the same unit in Germany and describe the well-known but still much discussed ways of improving the prognosis of patients undergoing cystectomy for bladder cancer. The authors review the roles of lymph node dissection and perioperative chemotherapy, and draw conclusions which will be of ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2007.07114.x

    authors: Suttmann H,Kamradt J,Lehmann J,Stöckle M

    更新日期:2007-12-01 00:00:00

  • A tertiary experience of vesico-vaginal and urethro-vaginal fistula repair: factors predicting success.

    abstract:OBJECTIVE:To review the outcomes of all patients referred with vesico-vaginal (V VF) and urethro-vaginal (UVF) fistulae to a tertiary centre, and to investigate the patient, fistula and surgical factors relevant to success. PATIENTS AND METHODS:We reviewed retrospectively the case-notes of 41 consecutive patients (32 ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08237.x

    authors: Ockrim JL,Greenwell TJ,Foley CL,Wood DN,Shah PJ

    更新日期:2009-04-01 00:00:00

  • Fertility managment in testicular cancer: the need to establish a standardized and evidence-based patient-centric pathway.

    abstract:OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14455

    authors: Moody JA,Ahmed K,Yap T,Minhas S,Shabbir M

    更新日期:2019-01-01 00:00:00

  • Renal functional outcomes for tumours in a solitary kidney managed by ablative or extirpative techniques.

    abstract:OBJECTIVE:To present the renal functional outcomes for patients treated with open partial nephrectomy (OPN) or radiofrequency ablation (RFA) for tumours in a solitary kidney, as renal masses in a solitary kidney present a challenging treatment dilemma. PATIENTS AND METHODS:A retrospective review of institutional datab...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2009.08776.x

    authors: Raman JD,Raj GV,Lucas SM,Williams SK,Lauer EM,Ahrar K,Matin SF,Leveillee RJ,Cadeddu JA

    更新日期:2010-02-01 00:00:00

  • Does patient age affect survival after radical cystectomy?

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Elderly patients have more years to compound comorbidities and it has previously been shown that comorbidity is an important predictor of overall survival in patients with bladder cancer, including those treated with radical cystectomy (RC). Other stu...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11180.x

    authors: Horovitz D,Turker P,Bostrom PJ,Mirtti T,Nurmi M,Kuk C,Kulkarni G,Fleshner NE,Finelli A,Jewett MA,Zlotta AR

    更新日期:2012-12-01 00:00:00

  • Androgen deprivation therapy: past, present and future.

    abstract::Since Huggins and Hodges demonstrated the responsiveness of prostate cancer to androgen deprivation therapy (ADT), androgen-suppressing strategies have formed the cornerstone of management of advanced prostate cancer. Approaches to ADT have included orchidectomy, oestrogens, luteinizing hormone-releasing hormone (LHRH...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2012.11215.x

    authors: Schröder F,Crawford ED,Axcrona K,Payne H,Keane TE

    更新日期:2012-06-01 00:00:00

  • Incontinence aids in Sweden: users and costs.

    abstract:OBJECTIVE:To study age- and sex-specific use and costs of incontinence aids distributed free of charge in Sweden. SUBJECTS AND METHODS:The study was conducted in the county of Jämtland, Sweden (132,000 inhabitants). The use and cost of incontinence aids for people living in their homes and the total cost of incontinen...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-4096.2001.01429.x

    authors: Samuelsson E,Månsson L,Milsom I

    更新日期:2001-12-01 00:00:00

  • Three-dimensional virtual imaging of renal tumours: a new tool to improve the accuracy of nephrometry scores.

    abstract:OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14894

    authors: Porpiglia F,Amparore D,Checcucci E,Manfredi M,Stura I,Migliaretti G,Autorino R,Ficarra V,Fiori C

    更新日期:2019-12-01 00:00:00

  • Analysis of the long-term outcome of surgically corrected vesico-ureteric reflux.

    abstract:OBJECTIVE:To review patients who had vesico-ureteric reflux corrected surgically by ureteric reimplantation during childhood, and thus assess their long-term outcome. PATIENTS AND METHODS:Between 1970 and 1979, 322 children underwent ureteric reimplantation; 100 (79 women and 21 men) were re-assessed and the long-term...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04264.x

    authors: Mor Y,Leibovitch I,Zalts R,Lotan D,Jonas P,Ramon J

    更新日期:2003-07-01 00:00:00

  • Serous-lined, stapled pouch wall plication: initial results of a simple and quick novel continence mechanism in troubleshooting secondary to continent cutaneous urinary diversion.

    abstract:OBJECTIVES:To report a novel and straightforward technique of a secondary continent outlet for continent cutaneous urinary diversion (CCUD) reservoirs without the need for further bowel resection, reducing operating time and length of hospitalization. PATIENTS AND METHODS:From 2015 to 2017, six patients with unreconst...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13979

    authors: Riedmiller H,Kocot A,Kalogirou C

    更新日期:2018-01-01 00:00:00

  • Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract.

    abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2009.08696.x

    authors: Phé V,Cussenot O,Rouprêt M

    更新日期:2009-10-01 00:00:00

  • A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.

    abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2010.09801.x

    authors: Ye Z,Yang H,Li H,Zhang X,Deng Y,Zeng G,Chen L,Cheng Y,Yang J,Mi Q,Zhang Y,Chen Z,Guo H,He W,Chen Z

    更新日期:2011-07-01 00:00:00

  • Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging.

    abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06515.x

    authors: Coakley FV,Chen I,Qayyum A,Westphalen AC,Carroll PR,Hricak H,Chen MH,Kurhanewicz J

    更新日期:2007-01-01 00:00:00

  • Long-term oncological outcomes of patients with paratesticular sarcoma.

    abstract:OBJECTIVES:To present long-term oncological outcomes of patients with paratesticular sarcoma treated by a multidisciplinary team. PATIENTS AND METHODS:Patients managed at the Princess Margaret Cancer Centre, between 1990 and 2012, were analysed. A sarcoma expert performed central pathology review. Kaplan-Meier graphs ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14775

    authors: Goldberg H,Wong LM,Dickson B,Catton C,Yap SA,Alkasab T,Evans A,van der Kwast T,Jewett MAS,Hamilton RJ

    更新日期:2019-11-01 00:00:00

  • Long-term follow-up of treatment of erectile dysfunction after radical prostatectomy using nerve grafts and end-to-side somatic-autonomic neurorraphy: a new technique.

    abstract:OBJECTIVE:To study a novel penile reinnervation technique using four sural nerve grafts and end-to-side neurorraphies connecting bilaterally the femoral nerve and the cavernous corpus and the femoral nerve and the dorsal penile nerves. PATIENTS AND METHODS:Ten patients (mean [± sd; range] age 60.3 [± 4.8; 54-68] years...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13772

    authors: Souza Trindade JC,Viterbo F,Petean Trindade A,Fávaro WJ,Trindade-Filho JCS

    更新日期:2017-06-01 00:00:00

  • Urethral replacement: a comparison between small intestinal submucosa grafts and spontaneous regeneration.

    abstract:OBJECTIVE:To evaluate the use of commercially available single-layer small intestinal submucosa (SIS) for urethral replacement, both as an onlay and as a tube, in a rabbit model. MATERIALS AND METHODS:Thirty-six male rabbits were assigned to four experimental groups. Group 1 had the ventral wall of the penile urethra ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05115.x

    authors: El-Assmy A,El-Hamid MA,Hafez AT

    更新日期:2004-11-01 00:00:00