Abstract:
:Since Huggins and Hodges demonstrated the responsiveness of prostate cancer to androgen deprivation therapy (ADT), androgen-suppressing strategies have formed the cornerstone of management of advanced prostate cancer. Approaches to ADT have included orchidectomy, oestrogens, luteinizing hormone-releasing hormone (LHRH) agonists, anti-androgens and more recently the gonadotrophin-releasing hormone antagonists. The most extensively studied antagonist, degarelix, avoids the testosterone surge and clinical flare associated with LHRH agonists, offering more rapid PSA and testosterone suppression, improved testosterone control and improved PSA progression-free survival compared with agonists. The clinical profile of degarelix appears to make it a particularly suitable therapeutic option for certain subgroups of patients, including those with metastatic disease, high baseline PSA (>20 ng/mL) and highly symptomatic disease. As well as forming the mainstay of treatment for advanced prostate cancer, ADT is increasingly used in earlier disease stages. While data from clinical trials support the use of ADT neoadjuvant/adjuvant to radiotherapy for locally advanced or high-risk localized prostate cancer, it remains to be established whether specific ADT classes/agents provide particular benefits in this clinical setting.
journal_name
BJU Intjournal_title
BJU internationalauthors
Schröder F,Crawford ED,Axcrona K,Payne H,Keane TEdoi
10.1111/j.1464-410X.2012.11215.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
1-12eissn
1464-4096issn
1464-410Xjournal_volume
109 Suppl 6pub_type
杂志文章,评审abstract:UNLABELLED:What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10848.x
更新日期:2012-09-01 00:00:00
abstract::What's known on the subject? and What does the study add? • Six targeted agents--sorafenib, sunitinib, pazopanib, bevacizumab, temsirolimus and everolimus--have been approved for the treatment of advanced renal cell carcinoma (RCC) based on evidence from large randomized controlled trials (RCTs). However, no head-to-h...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2010.09829.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:• o determine differences in surgical outcomes by surgical approach during a period of rapid adoption of minimally invasive surgical approaches in radical prostatectomy. PATIENTS AND METHODS:• We identified 19 542 men undergoing minimally invasive (MIRP), perineal (PRP), and retropubic (RRP) radical prostate...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09822.x
更新日期:2011-07-01 00:00:00
abstract::What's known on the subject? and What does the study add? Angiosarcomas are histological subtype of sarcomas and rarely involve the prostate gland. Only ten cases of prostate angiosarcoma have been reported in the literature to date. Occurrence of post-irradiation prostate angiosarcoma is rare considering the frequenc...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11202.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy, evaluate the safety and assess side-effects (swelling, haematoma and pain) of percutaneous vas occlusion compared with vasectomy in Dutch men. PATIENTS AND METHODS:Vas occlusion and vasectomy procedures (attempted in 58 and 50 men, respectively) were conducted at the University Ho...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00875.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04185.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To assess the possible relationship between treatment with selective serotonin-reuptake inhibitors (SSRIs) and the occurrence of nocturia. SUBJECTS AND METHODS:An unselected group of adult men and women, living in the city of Ostersund, Sweden, were sent a postal questionnaire containing questions on somatic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05408.x
更新日期:2005-04-01 00:00:00
abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07594.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To assess the expression of the tumour markers stromelysin 3, MUC1, p53 and cytokeratin-7 in papillary renal cell carcinoma (pRCC, for which two histological subtypes are distinguished, i.e. type 1 and type 2, the latter appearing to be associated with a poorer prognosis) and to determine whether any of these...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07605.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To report a large multi-institutional series of laparoendoscopic single-site (LESS) nephroureterectomy (NU). MATERIALS AND METHODS:Data on all cases of LESS-NU performed between 2008 and 2012 at 15 institutions were retrospectively gathered. The main demographic data and perioperative outcomes were analysed....
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11775.x
更新日期:2013-09-01 00:00:00
abstract::The introduction of prostate-specific antigen (PSA) has revolutionized the detection and management of patients with prostate cancer. Despite this there has always been a concern among clinicians about the usefulness of total PSA levels as a marker for prostate cancer. We discuss the use of calculated variables and mo...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07283.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To report our experience of using laparoscopy for the accurate location and simultaneous removal of small dysplastic kidneys with ectopic ureteric insertion causing urinary incontinence and that were not detected by conventional imaging modalities. PATIENTS AND METHODS:Seven girls (mean age 7.9 years, range ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00162.x
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. MATERIALS AND METHODS:Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8 weeks; gr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08261.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To compare interpretations of electromyographic (EMG) recordings from perineal surface patch electrodes (PSPEs) to those from urethral concentric needle electrodes (CNEs) during voiding. PATIENTS AND METHODS:Consenting women underwent urodynamic testing with a 30 G, 3.8 cm CNE at the 12 o'clock position in t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05890.x
更新日期:2006-01-01 00:00:00
abstract::There has been a recent increase in mumps orchitis among pubertal and postpubertal males. These outbreaks can be attributed to a reduction in the uptake of measles-mumps-rubella (MMR) vaccine during the early to mid-1990 s in children who have now matured. The mumps virus is commonly associated with extra-salivary com...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.09148.x
更新日期:2010-04-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The management of patients with non-obstructive azoospermia (NOA) involves testicular sperm extraction (TESE or microdissection TESE) combined with intracytoplasmic sperm injection (ICSI). Sperm retrieval is successful in up to 50% of men with NOA; h...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11203.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10434.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To characterise the outcomes of neoadjuvant chemotherapy (NAC) pre-treated patients found to be lymph node (LN)-positive at the time of radical cystectomy and pelvic lymph node dissection (RC/PLND) for urothelial carcinoma of the bladder (UCB). PATIENTS AND METHODS:Of 1484 patients treated with RC/PLND for ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14242
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:• To systematically review the current literature concerning perioperative, functional and oncological outcomes reported after open and minimally invasive prostate cancer surgery specifically from institutions within Australasia. MATERIALS AND METHODS:• Four electronic databases were searched to identify s...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10053.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06515.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:•To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS:•At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10207.x
更新日期:2011-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Recent studies have indicated that high mobility group box 1 (HMGB1) is related to the development and progression of human carcinomas. However, further studies were required to confirm the roles played by HMGB1 in clinical prostate cancer treatment. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11277.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that benign prostatic hyperplasia (BPH) robotic surgery with aquablation would have a more pronounced benefit in certain patient subgroups, such as men with more challenging anatomies (e.g. large prostates, large middle lobes) and men with moderate BPH. METHODS:We conducted prespecifie...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14426
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To determine whether very small prostate cancers present in patients who also have lymph node (LN) metastases represent a particularly aggressive disease variant compared with larger LN-positive tumours. PATIENTS AND METHODS:We identified 37 501 patients diagnosed with prostate cancer between 1988 and 2001 t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13248
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.10371.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12386
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine the angiogenic profiles in the bladder of patients with bladder pain syndrome (BPS)/interstitial cystitis (IC), and to evaluate the relationship between these profiles and associated clinical features including pelvic pain and glomerulations. PATIENTS AND METHODS:Angiogenesis and angiogenic comp...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08467.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of inside-out transobturator tape (tension-free vaginal tape-obturator, TVT-O) for the treatment of stress urinary incontinence (SUI). PATIENTS AND METHODS:Between August 2004 and August 2006, 87 consecutive patients with SUI who underwent TVT-O were enrolle...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14555
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00979.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To describe the influence of blood sampling/sampling tubes on mass spectrometric and clustering results, and on clinical blood variables, in blood samples collected from healthy volunteers and patients with prostate cancer. PATIENTS, SUBJECTS AND METHODS:Two venous blood samples were taken from 12 healthy vo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06678.x
更新日期:2007-03-01 00:00:00