Abstract:
:Detailed molecular insights into bladder cancer biology might allow more detailed prognostication and optimization of treatment with the objective of improving patient outcome and quality of life. However, in bladder cancer research the search for biomarkers has been called into question and has even obtained notoriety. It is unlikely that any single marker will be able to improve prognostication for patients with bladder cancer above and beyond grade and stage, but a combination of multiple independent markers might more precisely predict the outcome. From a previous review, we identified seven biomarkers to study within the setting of the Bladder Cancer Prognosis Programme (BCPP), a 5-year multicentre programme of research based at the University of Birmingham and funded by Cancer Research UK, investigating their effectiveness in predicting recurrence and progression. As part of the ongoing quality-assurance process for BCPP we present an updated review of our selected biomarkers, as well as highlighting other recent important developments in bladder cancer research.
journal_name
BJU Intjournal_title
BJU internationalauthors
Bryan RT,Zeegers MP,James ND,Wallace DM,Cheng KKdoi
10.1111/j.1464-410X.2009.08880.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
608-13issue
5eissn
1464-4096issn
1464-410Xpii
BJU8880journal_volume
105pub_type
杂志文章,评审abstract:OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04185.x
更新日期:2003-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The clinical presentation and complications of lichen sclerosus are well known. What is less well known is the true incidence of the condition. The published figures are all based on attendance at general medical clinics or specialist clinics, but it ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10699.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To review a series of children with anterior urethral valves and diverticula, to elucidate the pathophysiology and optimal management of this entity. PATIENTS AND METHODS:Nine cases (all boys; 1963 to 2003) were reviewed retrospectively. RESULTS:Seven of nine boys had bulbar diverticula. Continuity between ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04854.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To review our experience of using the tubularized incised plate (TIP) urethroplasty (useful in the treatment of distal hypospadias) to treat proximal hypospadias. MATERIALS AND METHODS:From March 1997 to March 2000 primary repairs were carried out on 40 boys (mean age 4.5 years) with proximal hypospadias. Af...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00966.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To evaluate how many patients could have undergone partial nephrectomy (PN) rather than radical nephrectomy (RN) before and after neoadjuvant axitinib therapy, as assessed by five independent urological oncologists, and to study the variability of inter-observer agreement. PATIENTS AND METHODS:Pre- and post-...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.13188
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To obtain community-based information about the incidence of interstitial cystitis, a chronic disabling condition of the bladder where knowledge is limited because there are no definitive diagnostic criteria. PATIENTS AND METHODS:All residents of Olmsted County, MN, USA who had received a physician-assigned ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04060.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To determine if patients who undergo tubularized incised-plate (TIP) urethroplasty need regular dilatation to prevent neourethral strictures or meatal stenosis. PATIENTS AND METHODS:The follow-up of two consecutive series of patients who underwent primary TIP hypospadias repair by one surgeon was reviewed. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01901.x
更新日期:2002-01-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10728.x
更新日期:2012-07-01 00:00:00
abstract::The aims of the present review were to assess the literature on published outcomes and complications associated with surgical treatments for Peyronie's disease (PD) and to assist clinicians in the effective management of PD by increasing understanding and awareness of the outcomes associated with current surgical trea...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12565
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of low-dose rate prostate brachytherapy on the sexual health of men with > or = 7 years of prospective evaluation and optimum sexual function before treatment. PATIENTS AND METHODS:In all, 223 patients with T1b to T3a prostate cancer and a median (range) age of 66 (50-82) years were tr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07016.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. PATIENTS AND METHODS:We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10422.x
更新日期:2012-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09986.x
更新日期:2011-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05741.x
更新日期:2005-11-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and what does the study add?: Only little and partly contradictory data are currently published about the prognostic role of immunohistochemically detectable proliferation-associated biomarkers in surgically treated squamous cell carcinoma of the penis (SCCP), and no data are ava...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11735.x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the oncological outcome and functional results of prostate-sparing cystectomy (PSC), proposed for treating bladder cancer, used since 1999 in our institution in an attempt to preserve male sexuality and to increase continence after cystectomy. PATIENTS AND METHODS:Between January 1999 and Decembe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05097.x
更新日期:2004-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07606.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS:From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically locali...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08012.x
更新日期:2009-02-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Systems for image guidance during laparoscopic surgery can be broadly defined as systems that enable the surgeon to refer to preoperatively gathered information during the procedure. For a laparoscopic system the preoperative information can be overl...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11692.x
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:To prospectively evaluate the accuracy of transvesical contrast-enhanced ultrasound (CEUS) as an alternative method for the detection of anastomotic leakage after radical retropubic prostatectomy (RRP) in comparison with the current standard method of conventional retrograde cystography (CG). PATIENTS AND...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09497.x
更新日期:2010-12-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00407.x
更新日期:2000-01-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/bju.14703
更新日期:2019-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09013.x
更新日期:2010-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06452.x
更新日期:2006-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00019.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:• To compare outcomes of hilar clamping and non-hilar clamping partial nephrectomy for tumours involving a solitary functional kidney. PATIENTS AND METHODS:• Between 1990 and 2009, 104 partial nephrectomies, excluding bench and autotransplant procedures, were performed on solitary functional kidneys. • An in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09713.x
更新日期:2011-06-01 00:00:00
abstract::OBJECTIVE To analyse the relationship between the number of nocturia episodes and other variables obtained from a bladder diary, with special attention to the duration of sleep, as nocturia is closely related to sleep disorders. PATIENTS, SUBJECTS AND METHODS Between April 2005 and December 2006, 532 participants, inc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08379.x
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To examine, in a retrospective analysis of outcome based on prostate-specific antigen (PSA) levels, whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression-free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer. PATIENTS AND ME...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.02420.x
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To present the results of the first clinical study of a synchronous twin-pulse technique for extracorporeal shock-wave lithotripsy (ESWL), which is effective for in vitro stone fragmentation and safe when assessed in vivo on animal tissue. PATIENTS AND METHODS:Fifty patients with urinary stones (35 men and 1...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2005.05306.x
更新日期:2005-02-01 00:00:00