Comparison of hilar clamping and non-hilar clamping partial nephrectomy for tumours involving a solitary kidney.

Abstract:

OBJECTIVE:• To compare outcomes of hilar clamping and non-hilar clamping partial nephrectomy for tumours involving a solitary functional kidney. PATIENTS AND METHODS:• Between 1990 and 2009, 104 partial nephrectomies, excluding bench and autotransplant procedures, were performed on solitary functional kidneys. • An institutional review board-approved retrospective review was performed analyzing patient demographics, operative data, complications, oncological outcomes and estimated glomerular filtration rate (GFR). • GFR was calculated using the abbreviated Modification of Diet in Renal Disease equation. • Preoperative GFR was compared to Early GFR (lowest measured GFR 7-100 days postoperatively) and to Late GFR (GFR 101-365 days postoperatively). • Multiple linear regression analysis was performed to assess covariates affecting Late GFR. • Kaplan-Meier estimator was utilized to compare renal cell carcinoma (RCC) specific survival and non-RCC-related survival. RESULTS:• In total, 29 partial nephrectomies with hilar clamping and 75 partial nephrectomies without hilar clamping were performed in solitary kidneys. Median follow-up was 57 months. • There was no difference in tumour size, location and the number of tumours resected between the two groups. Mean ischaemia time for the clamping group was 25 min. • Some 97% of the clamping procedures were performed with cold ischaemia. • There was no difference in intra-operative estimated blood loss, transfusion requirement or length of hospital stay. • The complication rate and spectrum of complications were similar between the two groups. • The two groups had similar preoperative GFR and Early GFR. The non-clamping group had a significantly smaller percent decrease in Late GFR (11.8% vs 27.7%, P= 0.01) than the clamping group. • The non-clamping group was significantly more likely to have a less than 10% decrease in Late GFR compared to the clamping group (60.9% vs 17.7%, P= 0.002). • On multivariate analysis, only hilar clamping was significantly associated with decreased Late GFR (estimate 15.0, P= 0.02). • Surgical margin positivity rate was higher in the clamping group (21% vs 4%, P= 0.01); however, the local recurrence rate between the two groups was similar. • The clamping and non-clamping groups had similar 5-year RCC-specific survival and 5-year non-RCC-related survival. CONCLUSIONS:• Partial nephrectomy without hilar clamping in solitary kidneys provides similar cancer control compared to partial nephrectomy with hilar clamping. • Partial nephrectomy without clamping was associated with superior preservation of Late GFR. • No difference was detected in GFR early after surgery, possibly indicating that there may be ongoing renal loss after hilar clamping.

journal_name

BJU Int

journal_title

BJU international

authors

Wszolek MF,Kenney PA,Lee Y,Libertino JA

doi

10.1111/j.1464-410X.2010.09713.x

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

1886-92

issue

12

eissn

1464-4096

issn

1464-410X

journal_volume

107

pub_type

杂志文章
  • Live surgical education: a perspective from the surgeons who perform it.

    abstract:OBJECTIVE:To evaluate the experience and views regarding live surgical broadcasts (LSB) among European urologists attending the European Association of Urology Robotic Urology Society (ERUS) congress in September 2012. MATERIALS AND METHODS:An anonymous survey was distributed via email inviting the participants of the...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12283

    authors: Khan SA,Chang RT,Ahmed K,Knoll T,van Velthoven R,Challacombe B,Dasgupta P,Rane A

    更新日期:2014-07-01 00:00:00

  • A longitudinal study of anxiety, depression and distress as predictors of sexual and urinary quality of life in men with prostate cancer.

    abstract:OBJECTIVE:To evaluate the prevalence of depression, anxiety and distress among active surveillance (AS) and radical prostatectomy (RP) patients. To evaluate the impact of these symptoms at baseline on urinary and sexual quality of life at follow-up. PATIENTS AND METHODS:Patients managed with AS or RP who completed val...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12209

    authors: Punnen S,Cowan JE,Dunn LB,Shumay DM,Carroll PR,Cooperberg MR

    更新日期:2013-07-01 00:00:00

  • Gleason 7 prostate cancer treated with low-dose-rate brachytherapy: lack of impact of primary Gleason pattern on biochemical failure.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incid...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11057.x

    authors: Stock RG,Berkowitz J,Blacksburg SR,Stone NN

    更新日期:2012-11-01 00:00:00

  • Clinically unconfirmed positive urinary cytology: diagnostic implications and oncological outcomes.

    abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10210.x

    authors: Aharony S,Baniel J,Yossepowitch O

    更新日期:2011-10-01 00:00:00

  • Retroperitoneal laparoscopic vs open partial nephroureterectomy in children.

    abstract:OBJECTIVES:To compare the results of retroperitoneal laparoscopic with open partial nephroureterectomy. PATIENTS AND METHODS:Laparoscopic retroperitoneal partial nephroureterectomy was undertaken in 15 children (13 upper and two lower poles; median age at the time of surgery 61 months, range 5-212). A three-trocar ret...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04126.x

    authors: El-Ghoneimi A,Farhat W,Bolduc S,Bagli D,McLorie G,Khoury A

    更新日期:2003-04-01 00:00:00

  • Effect of testosterone administration to men with prostate cancer is unpredictable: a word of caution and suggestions for a registry.

    abstract::To assess the evidence for the concept that the androgen receptor of prostate cancer (PCa) cells becomes saturated when testosterone values exceed castrate levels, so that testosterone administration in hypogonadal men with untreated PCa does not stimulate tumour growth. To propose basic criteria for administration of...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2011.10193.x

    authors: Morales A

    更新日期:2011-05-01 00:00:00

  • Does mirabegron relieve ureteric stent-related discomfort? A prospective, randomized, multicentre study.

    abstract:OBJECTIVES:To evaluate the effects of 50 mg mirabegron once daily for ureteric stent-related discomfort after ureteroscopic procedures by conducting a multicentre randomized study. PATIENTS AND METHODS:A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal su...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bju.14416

    authors: Tae BS,Cho S,Jeon BJ,Choi H,Park JY,Cho SY,Lee KC,Bae JH

    更新日期:2018-11-01 00:00:00

  • Efficacy of tolterodine as a first-line treatment for non-neurogenic voiding dysfunction in children.

    abstract:OBJECTIVE:To assess the effect of antimuscarinic treatment with tolterodine combined with behavioural modification as a first-line treatment, before invasive investigation, in children with non-neurogenic voiding dysfunction but no obvious anatomical or neurogenic cause. PATIENTS AND METHODS:The study comprised 44 chi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05641.x

    authors: Ayan S,Kaya K,Topsakal K,Kilicarslan H,Gokce G,Gultekin Y

    更新日期:2005-08-01 00:00:00

  • Construction of tissue-engineered corpus cavernosum with muscle-derived stem cells and transplantation in vivo.

    abstract:OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09695.x

    authors: Ji C,Min F,Liang W,Chen Y,Pan S,Bin L,Chen S,Wei Z,He T,Gu Y,Zhang J

    更新日期:2011-05-01 00:00:00

  • Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention.

    abstract:OBJECTIVE:To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. MATERIALS AND METHODS:The effi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10526.x

    authors: Chen SC,Grill WM,Fan WJ,Kou YR,Lin YS,Lai CH,Peng CW

    更新日期:2012-04-01 00:00:00

  • The prevalence of loss of heterozygosity in chromosome 3, including FHIT, in bladder cancer, using the fluorescent multiplex polymerase chain reaction.

    abstract:OBJECTIVE:To determine some of the genetic alterations involved in the pathogenesis and progression of transitional cell carcinoma of the bladder. Materials and methods In a population-based study, freshly frozen tissue was collected from all patients newly diagnosed with urinary bladder cancer in the Stockholm region ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02212.x

    authors: Wada T,Louhelainen J,Hemminki K,Adolfsson J,Wijkström H,Norming U,Borgström E,Hansson J,Steineck G

    更新日期:2001-06-01 00:00:00

  • Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical prostatectomy are common, although their impact on the risk of disease recurrence is unknown. We examined the impact of PSMs on the risk of 'significant' biochemical recurrence stratified by their risk of...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10868.x

    authors: Corcoran NM,Hovens CM,Metcalfe C,Hong MK,Pedersen J,Casey RG,Peters J,Harewood L,Goldenberg SL,Costello AJ,Gleave ME

    更新日期:2012-09-01 00:00:00

  • The catheterized patient undergoing transurethral resection of the prostate: a survey of the current practice of British urologists.

    abstract:OBJECTIVE:To determine, using a postal questionnaire survey of practising British consultant urologists, the duration and type of antibiotic deemed most effective in patients with an existing indwelling catheter before transurethral resection of the prostate (TURP), as the value of prophylactic antibiotics before TURP ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04429.x

    authors: Wilson JR,Puri R,Prescott S,Urwin GH

    更新日期:2003-10-01 00:00:00

  • Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.

    abstract:OBJECTIVE:To determine the role of hypoxia-inducible factor-2alpha (HIF2alpha) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2alpha protein levels. MATERIALS AND METHODS:Cell lines expressing stable short-hairpin ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07558.x

    authors: Bhatt RS,Landis DM,Zimmer M,Torregrossa J,Chen S,Sukhatme VP,Iliopoulos O,Balk S,Bubley GJ

    更新日期:2008-08-01 00:00:00

  • The prevalence of urinary incontinence in women in four European countries.

    abstract:OBJECTIVE:To determine the prevalence, type and treatment behaviour of women with urinary incontinence in four European countries. SUBJECTS AND METHODS:Data were collected using a postal survey which was sent to 29,500 community-dwelling women aged > or = 18 years in France, Germany, Spain and the UK. Subjects were as...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410x.2003.04609.x

    authors: Hunskaar S,Lose G,Sykes D,Voss S

    更新日期:2004-02-01 00:00:00

  • Comparison of oncological outcomes of transperitoneal and retroperitoneal laparoscopic radical nephrectomy for the management of clear-cell renal cell carcinoma: a multi-institutional study.

    abstract:OBJECTIVE:• To investigate the oncological efficacy of retroperitoneal laparoscopic radical nephrectomy (RLRN) compared with transperitoneal laparoscopic radical nephrectomy (TLRN) for the management of clear-cell renal cell carcinoma (RCC). PATIENTS AND METHODS:• With emphasis on survival and disease recurrence, a re...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2010.09636.x

    authors: Ha US,Hwang TK,Kim YJ,Oh TH,Jeon YS,Lee W,Lim JS,Lee TY,Choi Y,Park SK,Byun SS

    更新日期:2011-05-01 00:00:00

  • The role of urine cytology in the assessment of lower urinary tract symptoms.

    abstract:OBJECTIVE:To evaluate the role of urine cytology in the investigation of men with lower urinary tract symptoms (LUTS) in the absence of haematuria. PATIENTS AND METHODS:The study comprised 336 men attending a LUTS assessment clinic, who had neither macroscopic nor microscopic haematuria. One sample of urine was collec...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00151.x

    authors: Potter JM,Quigley M,Pengelly AW,Fawcett DP,Malone PR

    更新日期:1999-07-01 00:00:00

  • Functional and oncological outcomes after orthotopic neobladder reconstruction in women.

    abstract:OBJECTIVE:To review our experience with orthotopic neobladder reconstruction (ONR) in women, highlighting functional and oncological outcomes, as ONR has been used increasingly for urinary diversion in women after radical cystectomy (RC), largely due to a better understanding of the natural history of urothelial cell c...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07909.x

    authors: Granberg CF,Boorjian SA,Crispen PL,Tollefson MK,Farmer SA,Frank I,Blute ML

    更新日期:2008-12-01 00:00:00

  • Identification of novel oncogenic events occurring early in prostate carcinogenesis using purified autologous malignant and non-malignant prostate epithelial cells.

    abstract:OBJECTIVE:To interrogate enriched prostate cancer cells and autologous non-malignant prostate epithelial cells from men with localized prostate cancer, in order to identify early oncogenic pathways. PATIENTS AND METHODS:We collected malignant and matched non-malignant prostatectomy samples from men with adenocarcinoma...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14695

    authors: Sluka P,Pezaro C,Wardan H,Sengupta S,Davis ID

    更新日期:2019-05-01 00:00:00

  • Bladder augmentation with different forms of intestinal grafts: an experimental study in the pig.

    abstract:OBJECTIVE:To create an experimental animal model to examine changes in bladder volume and histology after bladder augmentation in growing individuals and from the model, evaluate a method using demucosalized intestinal grafts and short-term bladder drainage. MATERIALS AND METHODS:The study comprised 21 piglets: in gro...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00895.x

    authors: Clementson Kockum C,Willén R,Malmfors G

    更新日期:1999-02-01 00:00:00

  • The pitfalls of vaginal construction.

    abstract:OBJECTIVE:To evaluate a group of young women undergoing complex vaginoplasty, which may be defined as where there has already been previous complex pelvic surgery and the patient is unsuitable for conservative treatment or minor surgical revision. PATIENTS AND METHODS:All patients who had undergone a complex vaginopla...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05522.x

    authors: Davies MC,Creighton SM,Woodhouse CR

    更新日期:2005-06-01 00:00:00

  • Antidiuresis: a new concept in managing female daytime urinary incontinence.

    abstract:OBJECTIVE:To investigate the efficacy of desmopressin nasal spray on daytime urinary incontinence in women. PATIENTS AND METHODS:A multicentre, multinational, randomized, double-blind, placebo-controlled, cross-over exploratory study of women (aged 18-80 years) complaining of severe daytime urinary incontinence was co...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2004.04768.x

    authors: Robinson D,Cardozo L,Akeson M,Hvistendahl G,Riis A,Norgaard JP

    更新日期:2004-05-01 00:00:00

  • Assessing the anatomical characteristics of renal masses has a limited effect on the prediction of pathological outcomes in solid, enhancing, small renal masses: results using the PADUA classification system.

    abstract:OBJECTIVE:To evaluate whether assessing the anatomical characteristics of renal masses increases the accuracy of prediction of tumour pathology in small renal masses (SRMs). PATIENTS AND METHODS:We retrospectively reviewed 1129 consecutive patients who underwent extirpative surgeries for a clinical T1 renal mass, for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12446

    authors: Shin TY,Kim J,Koo KC,Lim SK,Kim DW,Kang MW,Rha KH,Choi YD,Ham WS

    更新日期:2014-05-01 00:00:00

  • Diagnostic accuracy of a five-point Likert scoring system for magnetic resonance imaging (MRI) evaluated according to results of MRI/ultrasonography image-fusion targeted biopsy of the prostate.

    abstract:OBJECTIVE:To evaluate the accuracy of a magnetic resonance imaging (MRI)-based Likert scoring system in the detection of clinically significant prostate cancer (CSPC), using MRI/ultrasonography (US) image-fusion targeted biopsy (FTB) as a reference standard. PATIENTS AND METHODS:We retrospectively reviewed 1218 MRI-de...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13972

    authors: Shin T,Smyth TB,Ukimura O,Ahmadi N,de Castro Abreu AL,Ohe C,Oishi M,Mimata H,Gill IS

    更新日期:2018-01-01 00:00:00

  • Role of alpha1-blockers in chronic prostatitis syndromes.

    abstract::Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1464-410X.2008.07496.x

    authors: Nickel JC

    更新日期:2008-03-01 00:00:00

  • Erectile rehabilitation with intracavernous alprostadil after radical prostatectomy: refusal and dropout rates.

    abstract:UNLABELLED:Study Type--Therapy (outcomes) Level of Evidence 2a. What's known on the subject? and What does the study add? Erectile dysfunction (ED) is a well known implication of radical prostatectomy (RP). Despite the search for technical improvement in the surgical procedure (e.g. nerve-sparing surgery, robot-assiste...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11484.x

    authors: Polito M,d'Anzeo G,Conti A,Muzzonigro G

    更新日期:2012-12-01 00:00:00

  • Effect of dutasteride, tamsulosin and the combination on patient-reported quality of life and treatment satisfaction in men with moderate-to-severe benign prostatic hyperplasia: 2-year data from the CombAT trial.

    abstract:OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial. PATIENTS AND MET...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2009.08196.x

    authors: Barkin J,Roehrborn CG,Siami P,Haillot O,Morrill B,Black L,Montorsi F,CombAT Study Group.

    更新日期:2009-04-01 00:00:00

  • Endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer.

    abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1464-410x.1999.00028.x

    authors: Sarosdy MF,Schellhammer PF,Soloway MS,Vogelzang NJ,Crawford ED,Presti J,Chodak GW,Mitchell P,Porter L

    更新日期:1999-05-01 00:00:00

  • Purification of human muscle-derived cells using an immunoselective method for potential use in urological regeneration.

    abstract:OBJECTIVE:To purify human muscle-derived cells (hMDCs) that could be used for managing urinary incontinence, erectile dysfunction and for bladder reconstitution. MATERIALS AND METHODS:hMDCs isolated by a modified preplate technique (MPT) from skeletal muscles of limbs were purified by CD34 antibody and magnetic Dynabe...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.09032.x

    authors: Lu SH,Yang AH,Chen KK,Chiang HS,Chang LS

    更新日期:2010-06-01 00:00:00

  • Current status of validation for robotic surgery simulators - a systematic review.

    abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2012.11270.x

    authors: Abboudi H,Khan MS,Aboumarzouk O,Guru KA,Challacombe B,Dasgupta P,Ahmed K

    更新日期:2013-02-01 00:00:00