Cyclooxygenase-2 (COX-2) inhibition for prostate cancer chemoprevention: double-blind randomised study of pre-prostatectomy celecoxib or placebo.

Abstract:

OBJECTIVE:To evaluate the biological effects of selective cyclooxygenase-2 inhibition on prostate tissue in patients undergoing radical prostatectomy (RP). PATIENTS AND METHODS:Patients with localised prostate cancer were randomised to receive either celecoxib 400 mg twice daily or placebo for 4 weeks before RP. Specimens were analysed for levels of apoptosis, prostaglandins, and androgen receptor (AR). Effects on serum prostate-specific antigen (PSA) and postoperative opioid use were also measured. RESULTS:In all, 28 of 44 anticipated patients enrolled and completed treatment. One patient in the celecoxib arm had a myocardial infarction postoperatively. For this reason, and safety concerns in other studies, enrolment was halted. The apoptosis index (AI) in tumour cells was 0.29% [95% confidence interval (CI) 0.11-0.47%] vs 0.39% (95% CI 0.00-0.84%) in the celecoxib and placebo arms, respectively (P = 0.68). The AI in benign cells was 0.18% (95% CI 0.03-0.32%) vs 0.13% (95% CI 0.00-0.28%) in the celecoxib and placebo arms, respectively (P = 0.67). Prostaglandin E2 and AR levels were similar in cancerous and benign tissues when comparing the two arms. The median baseline PSA level was 6.0 and 6.2 ng/mL for the celecoxib and placebo groups, respectively, and did not significantly change after celecoxib treatment. There was no difference in postoperative opiate usage between arms. CONCLUSION:Celecoxib had no effect on apoptosis, prostaglandins or AR levels in cancerous or benign prostate tissues. These findings coupled with drug safety concerns should serve to limit interest in these selective drugs as chemopreventive agents.

journal_name

BJU Int

journal_title

BJU international

authors

Flamiatos JF,Beer TM,Graff JN,Eilers KM,Tian W,Sekhon HS,Garzotto M

doi

10.1111/bju.13612

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

709-716

issue

5

eissn

1464-4096

issn

1464-410X

journal_volume

119

pub_type

杂志文章,随机对照试验
  • Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort.

    abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09321.x

    authors: Mishra GD,Cardozo L,Kuh D

    更新日期:2010-10-01 00:00:00

  • Long-term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years.

    abstract:OBJECTIVE:To assess the durability of holmium laser enucleation of prostate in comparison to transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were enrolled in the present study between June 1997 and December 2000 and followed per protocol. All patients were urodynamically obstructed with a...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2011.10359.x

    authors: Gilling PJ,Wilson LC,King CJ,Westenberg AM,Frampton CM,Fraundorfer MR

    更新日期:2012-02-01 00:00:00

  • MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.

    abstract:OBJECTIVE:To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model. MATERIALS AND METHODS:Sprague-Dawley rats of both sexes were divided into five groups of 10 each, with group 1...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06274.x

    authors: Rajasekaran M,Locke KW,Parsons CL

    更新日期:2006-08-01 00:00:00

  • Comprehensive assessment of renal tumour complexity in a large percutaneous cryoablation cohort.

    abstract:OBJECTIVE:To evaluate the association between renal tumour complexity and outcomes in a large cohort of patients undergoing percutaneous cryoablation (PCA). PATIENTS AND METHODS:Patients with renal tumours treated with PCA were identified using our prospectively maintained ablation registry (2003-2015). Salvage proced...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13841

    authors: Bhindi B,Thompson RH,Mason RJ,Haddad MM,Geske JR,Kurup AN,Hannon JD,Boorjian SA,Leibovich BC,Atwell TD,Schmit GD

    更新日期:2017-06-01 00:00:00

  • Assessing the anatomical characteristics of renal masses has a limited effect on the prediction of pathological outcomes in solid, enhancing, small renal masses: results using the PADUA classification system.

    abstract:OBJECTIVE:To evaluate whether assessing the anatomical characteristics of renal masses increases the accuracy of prediction of tumour pathology in small renal masses (SRMs). PATIENTS AND METHODS:We retrospectively reviewed 1129 consecutive patients who underwent extirpative surgeries for a clinical T1 renal mass, for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12446

    authors: Shin TY,Kim J,Koo KC,Lim SK,Kim DW,Kang MW,Rha KH,Choi YD,Ham WS

    更新日期:2014-05-01 00:00:00

  • Chemopreventive effects of cyclooxygenase-2 inhibitor and epidermal growth factor-receptor kinase inhibitor on rat urinary bladder carcinogenesis.

    abstract:OBJECTIVE:To examine the chemopreventive effects of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, and a selective epidermal growth factor (EGF)-receptor tyrosine kinase inhibitor, gefitinib (as a single agent) on a carcinogen-induced rodent bladder carcinogenesis model. MATERIALS AND METHODS:The study compr...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06053.x

    authors: Hattori K,Iida K,Joraku A,Tsukamoto S,Akaza H,Oyasu R

    更新日期:2006-03-01 00:00:00

  • Urethral replacement: a comparison between small intestinal submucosa grafts and spontaneous regeneration.

    abstract:OBJECTIVE:To evaluate the use of commercially available single-layer small intestinal submucosa (SIS) for urethral replacement, both as an onlay and as a tube, in a rabbit model. MATERIALS AND METHODS:Thirty-six male rabbits were assigned to four experimental groups. Group 1 had the ventral wall of the penile urethra ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05115.x

    authors: El-Assmy A,El-Hamid MA,Hafez AT

    更新日期:2004-11-01 00:00:00

  • A Phase III trial to investigate the timing of radiotherapy for prostate cancer with high-risk features: background and rationale of the Radiotherapy -- Adjuvant Versus Early Salvage (RAVES) trial.

    abstract:OBJECTIVES:To test the hypothesis that observation with early salvage radiotherapy (SRT) is not inferior to 'standard' treatment with adjuvant RT (ART) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins (SMs) after radical prostatectomy (RP). To compare the following secon...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bju.12623

    authors: Pearse M,Fraser-Browne C,Davis ID,Duchesne GM,Fisher R,Frydenberg M,Haworth A,Jose C,Joseph DJ,Lim TS,Matthews J,Millar J,Sidhom M,Spry NA,Tang CI,Turner S,Williams SG,Wiltshire K,Woo HH,Kneebone A

    更新日期:2014-03-01 00:00:00

  • Severe perineal pain after enterocystoplasty in bladder exstrophy.

    abstract:OBJECTIVE:To describe a previously unreported complication (severe perineal pain) after bladder reconstruction and enterocystoplasty in patients with bladder exstrophy. PATIENTS AND METHODS:The notes were reviewed retrospectively for four patients (two boys and two girls) with classical bladder exstrophy who had sever...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2003.04741.x

    authors: Phelps SR,Malone PS

    更新日期:2004-04-01 00:00:00

  • Incidence, prevalence and management of lower urinary tract symptoms in men in the UK.

    abstract:OBJECTIVE:To describe the incidence, prevalence and management of lower urinary tract symptoms (LUTS), suggestive of benign prostatic hyperplasia, reported in UK general practice. PATIENTS AND METHODS:All clinical information relating to LUTS and its treatment was assessed for men aged > or = 45 years and registered o...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05339.x

    authors: Logie J,Clifford GM,Farmer RD

    更新日期:2005-03-01 00:00:00

  • Radical prostatectomy in T4 prostate cancer after inductive androgen deprivation: results of a single-institution series with long-term follow-up.

    abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14393

    authors: Hajili T,Ohlmann CH,Linxweiler J,Niklas C,Janssen M,Siemer S,Stoeckle M,Saar M

    更新日期:2019-01-01 00:00:00

  • The control of haemolysis during transurethral resection of the prostate when water is used for irrigation: monitoring absorption by the ethanol method.

    abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00979.x

    authors: Hultén JO,Tran VT,Pettersson G

    更新日期:2000-12-01 00:00:00

  • Current status of validation for robotic surgery simulators - a systematic review.

    abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2012.11270.x

    authors: Abboudi H,Khan MS,Aboumarzouk O,Guru KA,Challacombe B,Dasgupta P,Ahmed K

    更新日期:2013-02-01 00:00:00

  • Gene expression profiling of renal cell carcinoma: a DNA macroarray analysis.

    abstract:OBJECTIVE:To examine differences in gene expression levels between renal cell carcinoma (RCC) tissue and 'normal' appearing renal tissue using a commercially available DNA macroarray. MATERIALS AND METHODS:Tissue was obtained from 47 consecutive radical nephrectomies, 29 of which were eligible. DNA macroarrays were an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06209.x

    authors: Lovisolo JA,Casati B,Clerici L,Marafante E,Bono AV,Celato N,Salvadore M

    更新日期:2006-07-01 00:00:00

  • Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention.

    abstract:OBJECTIVE:To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. MATERIALS AND METHODS:The effi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10526.x

    authors: Chen SC,Grill WM,Fan WJ,Kou YR,Lin YS,Lai CH,Peng CW

    更新日期:2012-04-01 00:00:00

  • Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy.

    abstract:OBJECTIVE:To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). PATIENTS AND METHODS:We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between Janu...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12329

    authors: Hattori S,Kosaka T,Mizuno R,Kanao K,Miyajima A,Yasumizu Y,Yazawa S,Nagata H,Kikuchi E,Mikami S,Jinzaki M,Nakagawa K,Tanimoto A,Oya M

    更新日期:2014-05-01 00:00:00

  • The Wallstent: long-term follow-up of metal stent placement for the treatment of benign ureteroileal anastomotic strictures after Bricker urinary diversion.

    abstract:OBJECTIVE:To evaluate the long-term follow-up (primary and secondary patency) of metal stent placement in benign ureteroileal anastomotic strictures after Bricker urinary diversion and to compare the failed treatment group with the group of successfully treated patients to search for predisposing factors of stent failu...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12729

    authors: Campschroer T,Lock MT,Lo RT,Bosch JL

    更新日期:2014-12-01 00:00:00

  • Poor prognosis of bladder cancer patients with occult lymph node metastases treated with neoadjuvant chemotherapy.

    abstract:OBJECTIVES:To characterise the outcomes of neoadjuvant chemotherapy (NAC) pre-treated patients found to be lymph node (LN)-positive at the time of radical cystectomy and pelvic lymph node dissection (RC/PLND) for urothelial carcinoma of the bladder (UCB). PATIENTS AND METHODS:Of 1484 patients treated with RC/PLND for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14242

    authors: Cha EK,Sfakianos JP,Sukhu R,Yee AM,Sjoberg DD,Bochner BH

    更新日期:2018-10-01 00:00:00

  • Prevalence of ciprofloxacin-resistant Enterobacteriaceae in the intestinal flora of patients undergoing transrectal prostate biopsy in Norwich, UK.

    abstract:OBJECTIVE:To determine the efficacy of fluoroquinolone prophylaxis in patients undergoing transrectal ultrasonography (TRUS)-guided biopsy of the prostate in the Norwich population, and its correlation with ciprofloxacin resistance in the faecal flora. We also aimed to determine the usefulness of a pre-biopsy rectal sc...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12865

    authors: Hanna MY,Tremlett C,Josan G,Eltom A,Mills R,Rochester M,Livermore DM

    更新日期:2015-07-01 00:00:00

  • Characteristics of protein excretion in patients with acute urinary retention.

    abstract:OBJECTIVE:To evaluate changes in protein leakage in the glomerular filtration barrier, and in the ability of the tubule to reabsorb proteins during and after acute urinary retention (AUR). PATIENTS AND METHODS:Glomerular and tubular function was investigated in 24 men during AUR (mean age 68 years, mean retention time...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02047.x

    authors: Mustonen S,Ala-Houhala IO,Tammela TL

    更新日期:2001-02-01 00:00:00

  • Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia.

    abstract:OBJECTIVE:To investigate whether fluid shear stress (FSS) induces endothelial nitric oxide synthase (eNOS) activity and NO production in isolated human corpus cavernosal endothelial cells (HCCECs), and whether this response is altered during hyperglycaemia in vitro, as haemodynamic signalling during penile erection ind...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06059.x

    authors: Wessells H,Teal TH,Engel K,Sullivan CJ,Gallis B,Tran KB,Chitaley K

    更新日期:2006-05-01 00:00:00

  • Does a nerve-sparing technique or potency affect continence after open radical retropubic prostatectomy?

    abstract:OBJECTIVE:To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). PATIENTS AND METHODS:Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Lo...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07921.x

    authors: Marien TP,Lepor H

    更新日期:2008-12-01 00:00:00

  • Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double-blind placebo-controlled crossover trial.

    abstract:OBJECTIVES:To assess the activity of baclofen, a potent gamma-aminobutyric acid-ergic agonist, against dysfunctional voiding (DV) and lower urinary tract symptoms (LUTS) in a clinical trial, as DV is a leading cause of LUTS in women, but there is no effective treatment. PATIENTS AND METHODS:We conducted a randomized d...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2007.06987.x

    authors: Xu D,Qu C,Meng H,Ren J,Zhu Y,Min Z,Kong Y

    更新日期:2007-09-01 00:00:00

  • Pelvi-ureteric junction obstruction in duplex kidneys.

    abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2007.07386.x

    authors: Horst M,Smith GH

    更新日期:2008-06-01 00:00:00

  • Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect.

    abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1464-410x.2001.02033.x

    authors: Berdeu D,Sauze L,Ha-Vinh P,Blum-Boisgard C

    更新日期:2001-02-01 00:00:00

  • Multicentre prospective evaluation of the learning curve of holmium laser enucleation of the prostate (HoLEP).

    abstract:OBJECTIVES:To describe the step-by-step learning curve of the holmium laser enucleation of the prostate (HoLEP) surgical technique. SUBJECTS/PATIENTS AND METHODS:A prospective, multicentre observational study was conducted, involving surgeons experienced in transurethral resection of the prostate and open prostatectom...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13124

    authors: Robert G,Cornu JN,Fourmarier M,Saussine C,Descazeaud A,Azzouzi AR,Vicaut E,Lukacs B

    更新日期:2016-03-01 00:00:00

  • Human papillomavirus prevalence, distribution and correlation to histopathological parameters in a large Swedish cohort of men with penile carcinoma.

    abstract:OBJECTIVE:• To analyse the overall and type-specific human papillomavirus (HPV) prevalence and distribution in penile carcinoma and determine the correlation to histopathological parameters. PATIENTS AND METHODS:• In this retrospective study, we analysed HPV status in 241 patients with penile carcinoma, treated at Öre...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09770.x

    authors: Kirrander P,Kolaric A,Helenius G,Windahl T,Andrén O,Stark JR,Lillsunde-Larsson G,Elgh F,Karlsson M

    更新日期:2011-08-01 00:00:00

  • Comparison of the clinical outcome after hormonal therapy for prostate cancer between Japanese and Caucasian men.

    abstract:OBJECTIVE:To investigate the impact of race on the effectiveness of hormonal therapy in patients with prostate cancer, by comparing the outcomes of Caucasian men (CM) and Japanese-American men (JAM) treated with hormonal therapy at one institution. PATIENTS AND METHODS:Fifty-nine CM and 105 JAM with prostate cancer we...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06201.x

    authors: Fukagai T,Namiki TS,Carlile RG,Yoshida H,Namiki M

    更新日期:2006-06-01 00:00:00

  • Percutaneous cryoablation of renal masses: Washington University experience of treating 129 tumours.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11432.x

    authors: Kim EH,Tanagho YS,Bhayani SB,Saad NE,Benway BM,Figenshau RS

    更新日期:2013-05-01 00:00:00

  • Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.10965.x

    authors: Ohmasa F,Saito M,Oiwa H,Tsounapi P,Shomori K,Kitatani K,Dimitriadis F,Kinoshita Y,Satoh K

    更新日期:2012-09-01 00:00:00