Abstract:
OBJECTIVE:To evaluate the biological effects of selective cyclooxygenase-2 inhibition on prostate tissue in patients undergoing radical prostatectomy (RP). PATIENTS AND METHODS:Patients with localised prostate cancer were randomised to receive either celecoxib 400 mg twice daily or placebo for 4 weeks before RP. Specimens were analysed for levels of apoptosis, prostaglandins, and androgen receptor (AR). Effects on serum prostate-specific antigen (PSA) and postoperative opioid use were also measured. RESULTS:In all, 28 of 44 anticipated patients enrolled and completed treatment. One patient in the celecoxib arm had a myocardial infarction postoperatively. For this reason, and safety concerns in other studies, enrolment was halted. The apoptosis index (AI) in tumour cells was 0.29% [95% confidence interval (CI) 0.11-0.47%] vs 0.39% (95% CI 0.00-0.84%) in the celecoxib and placebo arms, respectively (P = 0.68). The AI in benign cells was 0.18% (95% CI 0.03-0.32%) vs 0.13% (95% CI 0.00-0.28%) in the celecoxib and placebo arms, respectively (P = 0.67). Prostaglandin E2 and AR levels were similar in cancerous and benign tissues when comparing the two arms. The median baseline PSA level was 6.0 and 6.2 ng/mL for the celecoxib and placebo groups, respectively, and did not significantly change after celecoxib treatment. There was no difference in postoperative opiate usage between arms. CONCLUSION:Celecoxib had no effect on apoptosis, prostaglandins or AR levels in cancerous or benign prostate tissues. These findings coupled with drug safety concerns should serve to limit interest in these selective drugs as chemopreventive agents.
journal_name
BJU Intjournal_title
BJU internationalauthors
Flamiatos JF,Beer TM,Graff JN,Eilers KM,Tian W,Sekhon HS,Garzotto Mdoi
10.1111/bju.13612subject
Has Abstractpub_date
2017-05-01 00:00:00pages
709-716issue
5eissn
1464-4096issn
1464-410Xjournal_volume
119pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09321.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To assess the durability of holmium laser enucleation of prostate in comparison to transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were enrolled in the present study between June 1997 and December 2000 and followed per protocol. All patients were urodynamically obstructed with a...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10359.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model. MATERIALS AND METHODS:Sprague-Dawley rats of both sexes were divided into five groups of 10 each, with group 1...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06274.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between renal tumour complexity and outcomes in a large cohort of patients undergoing percutaneous cryoablation (PCA). PATIENTS AND METHODS:Patients with renal tumours treated with PCA were identified using our prospectively maintained ablation registry (2003-2015). Salvage proced...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13841
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To evaluate whether assessing the anatomical characteristics of renal masses increases the accuracy of prediction of tumour pathology in small renal masses (SRMs). PATIENTS AND METHODS:We retrospectively reviewed 1129 consecutive patients who underwent extirpative surgeries for a clinical T1 renal mass, for ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12446
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To examine the chemopreventive effects of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, and a selective epidermal growth factor (EGF)-receptor tyrosine kinase inhibitor, gefitinib (as a single agent) on a carcinogen-induced rodent bladder carcinogenesis model. MATERIALS AND METHODS:The study compr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06053.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of commercially available single-layer small intestinal submucosa (SIS) for urethral replacement, both as an onlay and as a tube, in a rabbit model. MATERIALS AND METHODS:Thirty-six male rabbits were assigned to four experimental groups. Group 1 had the ventral wall of the penile urethra ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05115.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that observation with early salvage radiotherapy (SRT) is not inferior to 'standard' treatment with adjuvant RT (ART) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins (SMs) after radical prostatectomy (RP). To compare the following secon...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.12623
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To describe a previously unreported complication (severe perineal pain) after bladder reconstruction and enterocystoplasty in patients with bladder exstrophy. PATIENTS AND METHODS:The notes were reviewed retrospectively for four patients (two boys and two girls) with classical bladder exstrophy who had sever...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2003.04741.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To describe the incidence, prevalence and management of lower urinary tract symptoms (LUTS), suggestive of benign prostatic hyperplasia, reported in UK general practice. PATIENTS AND METHODS:All clinical information relating to LUTS and its treatment was assessed for men aged > or = 45 years and registered o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05339.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14393
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00979.x
更新日期:2000-12-01 00:00:00
abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11270.x
更新日期:2013-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06209.x
更新日期:2006-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10526.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). PATIENTS AND METHODS:We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between Janu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12329
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term follow-up (primary and secondary patency) of metal stent placement in benign ureteroileal anastomotic strictures after Bricker urinary diversion and to compare the failed treatment group with the group of successfully treated patients to search for predisposing factors of stent failu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12729
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To characterise the outcomes of neoadjuvant chemotherapy (NAC) pre-treated patients found to be lymph node (LN)-positive at the time of radical cystectomy and pelvic lymph node dissection (RC/PLND) for urothelial carcinoma of the bladder (UCB). PATIENTS AND METHODS:Of 1484 patients treated with RC/PLND for ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14242
更新日期:2018-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12865
更新日期:2015-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02047.x
更新日期:2001-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06059.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). PATIENTS AND METHODS:Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Lo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07921.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:To assess the activity of baclofen, a potent gamma-aminobutyric acid-ergic agonist, against dysfunctional voiding (DV) and lower urinary tract symptoms (LUTS) in a clinical trial, as DV is a leading cause of LUTS in women, but there is no effective treatment. PATIENTS AND METHODS:We conducted a randomized d...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.06987.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02033.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:To describe the step-by-step learning curve of the holmium laser enucleation of the prostate (HoLEP) surgical technique. SUBJECTS/PATIENTS AND METHODS:A prospective, multicentre observational study was conducted, involving surgeons experienced in transurethral resection of the prostate and open prostatectom...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13124
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:• To analyse the overall and type-specific human papillomavirus (HPV) prevalence and distribution in penile carcinoma and determine the correlation to histopathological parameters. PATIENTS AND METHODS:• In this retrospective study, we analysed HPV status in 241 patients with penile carcinoma, treated at Öre...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09770.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of race on the effectiveness of hormonal therapy in patients with prostate cancer, by comparing the outcomes of Caucasian men (CM) and Japanese-American men (JAM) treated with hormonal therapy at one institution. PATIENTS AND METHODS:Fifty-nine CM and 105 JAM with prostate cancer we...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06201.x
更新日期:2006-06-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11432.x
更新日期:2013-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00