Abstract:
OBJECTIVE:To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. MATERIALS AND METHODS:The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined. RESULTS:The voiding efficiency (VE) was reduced from 69 to 22% after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62%. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T(9)-T(10), demonstrating the spinal origin of this augmenting reflex. CONCLUSIONS:The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.
journal_name
BJU Intjournal_title
BJU internationalauthors
Chen SC,Grill WM,Fan WJ,Kou YR,Lin YS,Lai CH,Peng CWdoi
10.1111/j.1464-410X.2011.10526.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
1051-8issue
7eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
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pub_type: 杂志文章,多中心研究
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