Androgen deprivation therapy for prostate cancer and risk of dementia.

Abstract:

OBJECTIVES:To study whether androgen deprivation therapy (ADT), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia. METHODS:Risk of dementia in men with prostate cancer primarily managed with ADT or watchful waiting (WW) in the Prostate Cancer Database Sweden, PCBaSe, was compared with that in prostate cancer-free men, matched on birth year and county of residency. We used Cox regression to calculate the hazard ratios (HRs) for Alzheimer's and non-Alzheimer's dementia (vascular dementia, dementia secondary to other diseases or unspecified dementias) for different types and duration of ADT and oral antiandrogens (AAs) as well as for men managed with WW. RESULTS:A total of 25 967 men with prostate cancer and 121 018 prostate cancer-free men were followed for a median of 4 years. In both groups 6% of the men were diagnosed with dementia. In men with prostate cancer, gonadotropin-releasing hormone agonist treatment ( HR 1.15, 95% confidence interval [CI] 1.07-1.23) and orchiectomy (HR 1.60, 95% CI 1.32-1.93) were associated with an increased risk of dementia, as compared to no treatment in prostate cancer-free men; however, this increase in risk was only observed for non-Alzheimer's dementia and occurred from year 1-4 after start of ADT. No increase in risk for any type of dementia was observed for men treated with AAs or for men on WW. CONCLUSION:This population-based cohort study does not support previous observations of an increased risk of Alzheimer's dementia for men on ADT; however, there was a small increase in risk of non-Alzheimer's dementia.

journal_name

BJU Int

journal_title

BJU international

authors

Robinson D,Garmo H,Van Hemelrijck M,Damber JE,Bratt O,Holmberg L,Wahlund LO,Stattin P,Adolfsson J

doi

10.1111/bju.14666

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

87-92

issue

1

eissn

1464-4096

issn

1464-410X

journal_volume

124

pub_type

杂志文章
  • Transcorporal artificial urinary sphincter implantation as a salvage surgical procedure for challenging cases of male stress urinary incontinence: surgical technique and functional outcomes in a contemporary series.

    abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12386

    authors: Wiedemann L,Cornu JN,Haab E,Peyrat L,Beley S,Cathelineau X,Haab F

    更新日期:2013-12-01 00:00:00

  • Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta-analysis.

    abstract::The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of pati...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/bju.14366

    authors: Gandhi N,Krishna S,Booth CM,Breau RH,Flood TA,Morgan SC,Schieda N,Salameh JP,McGrath TA,McInnes MDF

    更新日期:2018-11-01 00:00:00

  • Improved prognosis of patients with intermediate- and poor-risk nonseminomatous germ cell tumours by optimizing combined treatment.

    abstract:OBJECTIVE:To assess whether the optimal use of combined treatment with chemotherapy and appropriately timed surgical intervention by a specialized team might improve the outcome for patients with poor- and intermediate-prognosis (International Germ Cell Consensus Classification, IGCCC) nonseminomatous germ cell tumours...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04261.x

    authors: Pentheroudakis G,De Bono JS,Kaye SB,Simpson A,Paul J,Brown I,Pamenter B,Kirk A,Vasey P,Raby N,Kirk D

    更新日期:2003-07-01 00:00:00

  • Buccal mucosal grafts in the treatment of ureteric lesions.

    abstract:OBJECTIVE:To devise a procedure capable of curing complicated ureteric strictures and replacing segments of lost ureter, without the long-term infective complications of bowel interposition or the surgical magnitude of autotransplantation. PATIENTS AND METHODS:Four patients with complicated strictures and one with seg...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00019.x

    authors: Naude JH

    更新日期:1999-05-01 00:00:00

  • Improved quality of life in patients with overactive bladder symptoms treated with solifenacin.

    abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1464-410X.2004.05255.x

    authors: Kelleher CJ,Cardozo L,Chapple CR,Haab F,Ridder AM

    更新日期:2005-01-01 00:00:00

  • Angiotropism of human prostate cancer cells: implications for extravascular migratory metastasis.

    abstract:OBJECTIVES:To report several samples of invasive human prostate cancer showing angiotropism, and to use human prostate cancer cells stably expressing green fluorescence protein (GFP) in in vitro and in vivo models to assess the dissemination pathway of prostate cancer cells. MATERIALS AND METHODS:Malignant melanoma an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05474.x

    authors: Lugassy C,Vernon SE,Warner JW,Le CQ,Manyak M,Patierno SR,Barnhill RL

    更新日期:2005-05-01 00:00:00

  • The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer.

    abstract:OBJECTIVES:To compare the serum levels of insulin-like growth factor-1 (IGF-1) in patients with prostate cancer and in control patients with no malignancy, and to evaluate any possible influence of testicular androgen withdrawal on the level of IGF-1 in patients with prostate cancer. PATIENTS AND METHODS:IGF-1 was mea...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00350.x

    authors: Kurek R,Tunn UW,Eckart O,Aumüller G,Wong J,Renneberg H

    更新日期:2000-01-01 00:00:00

  • Extracorporeal shockwave lithotripsy vs ureteroscopy as first-line therapy for patients with single, distal ureteric stones: a prospective randomized study.

    abstract:OBJECTIVE:To compare extracorporeal shockwave lithotripsy (ESWL) and ureteroscopy (URS) as first-line treatments for patients with distal ureteric stones. PATIENTS AND METHODS:In all, 273 patients with single, monolateral, radiopaque, distal ureteric stones of 0.5-1.5 cm were enrolled in a prospective randomized trial...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2010.09338.x

    authors: Verze P,Imbimbo C,Cancelmo G,Creta M,Palmieri A,Mangiapia F,Buonopane R,Mirone V

    更新日期:2010-12-01 00:00:00

  • The management of secondary pelvi-ureteric junction obstruction - a comparison of pyeloplasty and endopyelotomy.

    abstract:OBJECTIVE:To review our experience in the management of secondary pelvi-ureteric junction obstruction (PUJO) comparing endopyelotomy with pyeloplasty. PATIENTS AND METHODS:We retrospectively analysed our database of 58 patients having undergone operative management of PUJO after failed primary management, including 41...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12454

    authors: Vannahme M,Mathur S,Davenport K,Timoney AG,Keeley FX Jr

    更新日期:2014-01-01 00:00:00

  • Age at surgery, educational level and long-term urinary incontinence after radical prostatectomy.

    abstract:OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to comple...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10231.x

    authors: Nilsson AE,Schumacher MC,Johansson E,Carlsson S,Stranne J,Nyberg T,Wiklund NP,Steineck G

    更新日期:2011-11-01 00:00:00

  • The optimal form of urinary drainage after acute retention of urine.

    abstract:OBJECTIVE:To assess the outcome of different forms of urinary drainage, particularly for urinary tract infection (UTI), operative findings and patient preference, in patients treated for acute urinary retention (AUR). PATIENTS AND METHODS:A feasibility trial was conducted of men presenting with AUR; after a short peri...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02253.x

    authors: Patel MI,Watts W,Grant A

    更新日期:2001-07-01 00:00:00

  • Expression of epithelial-mesenchymal transition markers in renal cell carcinoma: impact on prognostic outcomes in patients undergoing radical nephrectomy.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? There have been few studies evaluating the prognostic value of epithelial-mesenchymal transition markers in renal cell carcinoma (RCC); therefore, the significance of these markers in the prognosis of patients with RCC, particularly that in those with...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11297.x

    authors: Harada K,Miyake H,Kusuda Y,Fujisawa M

    更新日期:2012-12-01 00:00:00

  • Development and validation of an Arabic version of the International Prostate Symptom Score.

    abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08984.x

    authors: Hammad FT,Kaya MA

    更新日期:2010-05-01 00:00:00

  • Cost-effectiveness analysis of degarelix for advanced hormone-dependent prostate cancer.

    abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10434.x

    authors: Lu L,Peters J,Roome C,Stein K

    更新日期:2012-04-01 00:00:00

  • Changing practice in anterior urethroplasty.

    abstract:OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00010.x

    authors: Greenwell TJ,Venn SN,Mundy AR

    更新日期:1999-04-01 00:00:00

  • Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men.

    abstract:OBJECTIVE:To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) and fasting blood sugar (FBS), and to determine...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07774.x

    authors: Han JH,Chang IH,Ahn SH,Kwon OJ,Bang SH,Choi NY,Park SW,Myung SC,Kim HW

    更新日期:2008-11-01 00:00:00

  • Lower urinary tract symptoms and related help-seeking behaviour in South Asian men living in the UK.

    abstract:OBJECTIVE:To describe the pattern and prevalence of lower urinary tract symptoms (LUTS) and related help-seeking behaviour in men of South Asian origin living in the UK, and to compare this to the white population. SUBJECTS AND METHODS:Data were obtained as part of the Leicestershire MRC Incontinence Study. Community-...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06377.x

    authors: Taylor J,McGrother CW,Harrison SC,Assassa PR,Leicestershire MRC Incontinence Study Team.

    更新日期:2006-09-01 00:00:00

  • Effect of tadalafil 5 mg on post-micturition dribble in men with lower urinary tract symptoms: a multicentre, double-blind, randomized, placebo-controlled trial.

    abstract:OBJECTIVES:To compare the effects of taking tadalafil 5 mg and placebo once daily on post-micturition dribble (PMD) in men with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS:Our prospective, randomized, double-blind, placebo-controlled, multicentre trial enrolled 102 men with PMD and other LUTS. PMD was as...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bju.14849

    authors: Yang DY,Jeong HC,Ko K,Lee SH,Lee SK,Shin TY,Cho JS,Lee WK

    更新日期:2019-11-01 00:00:00

  • Does patient age affect survival after radical cystectomy?

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Elderly patients have more years to compound comorbidities and it has previously been shown that comorbidity is an important predictor of overall survival in patients with bladder cancer, including those treated with radical cystectomy (RC). Other stu...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11180.x

    authors: Horovitz D,Turker P,Bostrom PJ,Mirtti T,Nurmi M,Kuk C,Kulkarni G,Fleshner NE,Finelli A,Jewett MA,Zlotta AR

    更新日期:2012-12-01 00:00:00

  • Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis.

    abstract:OBJECTIVE:To examine the effect of age on the biochemical and functional properties, and regional distribution of endothelin (ET) receptors in the rabbit renal pelvis. MATERIALS AND METHODS:The properties of ET receptors in 6-week-old and 6-month-old male rabbit renal pelves were examined using isolated muscle-bath an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-4096.2001.2441.x

    authors: Wada Y,Latifpour J,Saito M,Afiatpour P,Weiss RM

    更新日期:2001-12-01 00:00:00

  • Hypertension in children with poorly functioning unilateral kidneys: predictors of resolution after nephrectomy.

    abstract:OBJECTIVE:To identify the outcome of nephrectomy and predictors of hypertension (HTN) resolution in children with poorly functioning unilateral kidneys (differential renal function, DRF of < 15%), as concurrent HTN is often an indication for nephrectomy. PATIENTS AND METHODS:Over a 7.5-year period, a single centre ret...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09308.x

    authors: El-Hout Y,Licht C,Pippi Salle JL,Ngan BY,Bagli DJ,Lorenzo AJ,Farhat WA

    更新日期:2010-11-01 00:00:00

  • The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats.

    abstract:OBJECTIVE:• To investigate the role of c-kit-positive interstitial cells (ICCs) in mediating muscarinic receptor-induced phasic contractions of isolated bladder strips from streptozotocin(STZ)-induced diabetic rats and to confirm the expression and location of ICCs in the rat bladder. MATERIALS AND METHODS:• Bladders ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09507.x

    authors: Vahabi B,McKay NG,Lawson K,Sellers DJ

    更新日期:2011-05-01 00:00:00

  • Clinical significance of prognosis using the neutrophil-lymphocyte ratio and erythrocyte sedimentation rate in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma.

    abstract:OBJECTIVES:To evaluate the clinical significance of preoperative erythrocyte sedimentation rate (ESR) and neutrophil-lymphocyte ratio (NLR) as prognostic factors in patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS:A total of 410 patients were retrospectiv...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12846

    authors: Sung HH,Jeon HG,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee HM

    更新日期:2015-04-01 00:00:00

  • Mirabegron causes relaxation of human and rat corpus cavernosum: could it be a potential therapy for erectile dysfunction?

    abstract:OBJECTIVE:To examine the effects of mirabegron, a selective β3 -adrenoceptor agonist that has recently been approved for the treatment of overactive bladder (OAB), on erectile function. Stimulation of β3 -adrenoceptors localised in cavernosal smooth muscle cells may play a physiological role in mediating penile erectio...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13515

    authors: Gur S,Peak T,Yafi FA,Kadowitz PJ,Sikka SC,Hellstrom WJ

    更新日期:2016-09-01 00:00:00

  • Experience with a bone anchor sling for treating female stress urinary incontinence: outcome at 30 months.

    abstract:OBJECTIVES:To evaluate the clinical and video-urodynamic outcome in women with by stress urinary incontinence (SUI) treated with a bone-anchored pubovaginal sling. PATIENTS AND METHODS:The study included 70 women with SUI (as evaluated by a clinical examination, a voiding questionnaire, a short pad-test and video-urod...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410x.2003.04749.x

    authors: Carbone A,Palleschi G,Ciavarella S,Morello P,Tomiselli G,Parascani R,Tubaro A

    更新日期:2004-04-01 00:00:00

  • Staging laparoscopic pelvic lymphadenectomy in prostate cancer.

    abstract:OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00931.x

    authors: Shackley DC,Irving SO,Brough WA,O'Reilly PH

    更新日期:1999-02-01 00:00:00

  • The conservative management of corynebacterium group D2 encrusted pyelitis.

    abstract:OBJECTIVE:To evaluate the conservative management of encrusted pyelitis (EP), an infectious disease caused by urea-splitting micro-organisms (Corynebacterium group D2 being the most common), and characterized by stone encrustation of the collecting system. PATIENTS AND METHODS:Four patients (aged 17-62 years) with EP ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00156.x

    authors: Meria P,Desgrippes A,Fournier R,Arfi C,Antoine C,Martinat L,Teillac P,Le Duc A

    更新日期:1999-08-01 00:00:00

  • Brucellar epididymo-orchitis in Saudi Arabia: a retrospective study of 26 cases and review of the literature.

    abstract:OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1464-410x.2001.02243.x

    authors: Memish ZA,Venkatesh S

    更新日期:2001-07-01 00:00:00

  • Predicting survival after radical cystectomy for bladder cancer.

    abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2008.07594.x

    authors: Margulis V,Lotan Y,Montorsi F,Shariat SF

    更新日期:2008-07-01 00:00:00

  • Staging lymphadenectomy in renal cell carcinoma must be extended: a sensitivity curve analysis.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: In renal cell carcinoma the role of lymphadenectomy (LND) is still controversial. Moreover, no firm consensus exists regarding the minimum number of lymph nodes that should be removed to obtain a satisfactory staging LND at the time of surgery. Our f...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11313.x

    authors: Capitanio U,Suardi N,Matloob R,Abdollah F,Castiglione F,Briganti A,Carenzi C,Roscigno M,Montorsi F,Bertini R

    更新日期:2013-03-01 00:00:00