Abstract:
OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to complete a study-specific questionnaire. Urinary leakage was defined as use of two or more pads per day. RESULTS:Questionnaires were received from 1288 (91%) patients with a median follow-up of 2.2 years. Age at surgery predicts in an exponential manner long-term urinary incontinence at follow-up with an estimated relative increase of 6% per year. Among the oldest patients, 19% had urinary incontinence compared with 6% in the youngest age group, translating to a prevalence ratio of 2.4 (95% confidence interval [CI], 1.5-8.1). Low educational level, as compared with high, yielded an increased age-adjusted prevalence ratio of 2.5 (95% CI, 1.7-3.9). Patients who had undergone salvage radiation therapy had an increased prevalence of urinary incontinence (2.5; 95% CI, 1.6-3.8), as did those with respiratory disease (2.4; 95% CI, 1.3-4.4). Body mass index, prostate weight, presence of diabetes or previous transurethral resection did not appear to influence the prevalence of urinary incontinence. CONCLUSIONS:In this series, a patient's age at radical prostatectomy influenced, in an exponential manner, his risk of long-term urinary incontinence. Other predictors are low educational level, salvage radiation therapy and respiratory disease. Intervention studies are needed to understand if these data are relevant to the prevalence of urinary leakage if a radical prostatectomy is postponed in an active monitoring programme.
journal_name
BJU Intjournal_title
BJU internationalauthors
Nilsson AE,Schumacher MC,Johansson E,Carlsson S,Stranne J,Nyberg T,Wiklund NP,Steineck Gdoi
10.1111/j.1464-410X.2011.10231.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
1572-7issue
10eissn
1464-4096issn
1464-410Xjournal_volume
108pub_type
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journal_title:BJU international
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2010.09801.x
更新日期:2011-07-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:BJU international
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更新日期:2012-12-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-08-01 00:00:00
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更新日期:2006-08-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2009-03-01 00:00:00
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-04-01 00:00:00
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更新日期:2007-11-01 00:00:00
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00