Abstract:
:OBJECTIVE To investigate the incidence of new-onset diabetes mellitus (NODM) and of worsening glycaemic control in established DM after starting androgen-deprivation therapy (ADT) for prostate cancer, as ADT is associated with altered body composition, potentially influencing insulin sensitivity. PATIENTS AND METHODS We retrospectively reviewed patients receiving ADT for prostate cancer at our institution between January 1989 and July 2005; those with incomplete information and those receiving only neoadjuvant ADT were excluded. Variables examined included age, race, body mass index (BMI), pretreatment prostate-specific antigen, Gleason sum, clinical stage, ADT type (medical vs surgical) and schedule (continuous vs intermittent), presence of pre-existing DM, serum glucose and glycosylated haemoglobin (HbA1c) levels before and after ADT, and receipt of vitamin D or bisphosphonate supplementation. Data were analysed statistically and P < 0.05 considered to indicate significance. RESULTS In all, 396 patients (median age 73.2 years; median BMI of 26.7 kg/m(2) at ADT initiation) were analysed. Of these, 59.1% were African-American and 40.9% were Caucasian/other. At a median follow-up of 60.1 months, 36 (11.3%) patients developed NODM. In 77 patients with pre-existing DM, there was an increase of >/=10% in serum HbA1c or fasting glucose levels in 15 (19.5%) and 22 (28.6%), respectively. On multivariate analysis, a BMI of >/=30 kg/m(2) was associated with an increased risk of developing NODM (odds ratio 4.65, P = 0.031). Receipt of vitamin D had a protective effect (odds ratio 5.75, P = 0.017). CONCLUSIONS Patients receiving ADT for prostate cancer with or with no history of DM should have routine surveillance of glycaemic control, particularly when their BMI is >/= 30 kg/m(2), with appropriate preventive and treatment measures.
journal_name
BJU Intjournal_title
BJU internationalauthors
Derweesh IH,Diblasio CJ,Kincade MC,Malcolm JB,Lamar KD,Patterson AL,Kitabchi AE,Wake RWdoi
10.1111/j.1464-410X.2007.07184.xsubject
Has Abstractpub_date
2007-11-01 00:00:00pages
1060-5issue
5eissn
1464-4096issn
1464-410Xpii
BJU7184journal_volume
100pub_type
杂志文章abstract:OBJECTIVE:To describe our current procedure of robot-assisted laparoscopic radical prostatectomy (RALP), and to assess the effect of the learning curve on perioperative data, early oncological outcomes and functional results, as RALP has increasingly become a treatment option for men with localized prostate cancer. PA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09013.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS:Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybri...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00654.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To determine the mechanism that underlies the effect of shock wave (SW) rate on the performance of clinical lithotripters. MATERIALS AND METHODS:The effect of firing rate on the pressure characteristics of SWs was assessed using a fibre-optic probe hydrophone (FOPH 500, RP Acoustics, Leutenbach, Germany). Sh...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07896.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14510
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To validate high-sensitivity C-reactive protein (hs-CRP) serum levels as an independent marker for disease-free survival (DFS) in clinically localised clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:In all, 403 consecutive patients with clinically localised (T1-3N0M0) ccRCC treated by radical o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12067
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. METHODS:Sensitiv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07653.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To describe the incidence, prevalence and management of lower urinary tract symptoms (LUTS), suggestive of benign prostatic hyperplasia, reported in UK general practice. PATIENTS AND METHODS:All clinical information relating to LUTS and its treatment was assessed for men aged > or = 45 years and registered o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05339.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02981.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:To present our experience with bladder cancer among a renal transplant population and to review critically the relevant literature. PATIENTS AND METHODS:In all, 1865 renal graft recipients were followed for a mean (SD) of 6.5 (5) years. Seven recipients (all men) developed a urothelial bladder tumour. The s...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07210.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10968.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To evaluate ultrasensitive (US) measurements of prostate-specific antigen (PSA) level in men with prostate cancer, and to correlate the findings with currently accepted values for PSA recurrence, as PSA is widely accepted as a surrogate marker for disease recurrence after treatment for prostate cancer, and al...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06294.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of a selective type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, IC486051, on bladder activity in normal rats and those with and bladder outlet obstruction (BOO), as inhibition of PDE4 leads to elevation of intracellular cAMP levels and relaxation of smooth muscle. MATER...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06643.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To identify differentially expressed genes between relapsed and non-relapsed clinical stage I testicular germ cell tumours (TGCTs). MATERIALS AND METHODS:We reviewed patients with clinical stage I non-seminoma and seminoma from an institutional database (2000-2012) who were managed by active surveillance. P...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14372
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07793.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term results and predictive risk factors for efficacy after the tension-free vaginal tape (TVT) procedure for treating female stress urinary incontinence (SUI). PATIENTS AND METHODS:Inall, 306 women (mean age 50.7 years, sd 8.7) who had a TVT procedure for SUI were selected and followed ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08504.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:• To investigate the influence of baseline variables on the 4-year incidence of acute urinary retention (AUR), benign prostatic hyperplasia (BPH)-related surgery and overall clinical progression in men treated with tamsulosin, dutasteride, or a combination of both. PATIENTS AND METHODS:• The 4-year Combinati...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2011.10124.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS:Men enrolled in the IMP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14412
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04237.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:To: (i) calculate traditional compliance (CTrad) for a normal bladder by DeltaV/DeltaPdet, where DeltaV is the mean volumetric capacity and DeltaPdet is the detrusor pressure rise; (ii) assess its usefulness; (iii) identify the variables that are necessary for correctly assessing bladder compliance; and (iv)...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05054.x
更新日期:2004-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Upper Urinary Tract (UUT) Transitional Cell Carcinoma (TCC) is an uncommon disease and represents approximately 5% of all urothelial carcinomas. We report our series on 73 patients treated with Kidney Sparing Surgery for UUT TCC. Good results have bee...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11554.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To report our 12-year experience with radiological treatment (ureteric embolization) for refractory urinary fistula, as malignancy, radiation therapy, and/or chronic inflammation increase the risk of lower urinary tract fistula after surgical urinary diversion, which can lead to significant morbidity, and for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06569.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of fluoroquinolone prophylaxis in patients undergoing transrectal ultrasonography (TRUS)-guided biopsy of the prostate in the Norwich population, and its correlation with ciprofloxacin resistance in the faecal flora. We also aimed to determine the usefulness of a pre-biopsy rectal sc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12865
更新日期:2015-07-01 00:00:00
abstract::What's known on the subject? and What does the study add? The suppressor effect of probiotics on superficial bladder cancer is an observed phenomenon but the specific mechanism is poorly understood. The evidence strongly suggests natural killer (NK) cells are the anti-tumour effector cells involved and NK cell activit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10749.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To characterize serial long-term histological changes in mesenchymal cells infiltrating a collagen-based matrix, as in a hollow organ with differentiated urothelial lining created intraperitoneally by grafting cultured urothelial cells, mesenchymal cells with smooth-muscle immunohistochemical characteristics ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05586.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the perioperative and pathological outcomes associated with robot-assisted radical prostatectomy (RARP) in morbidly obese men. PATIENTS AND METHODS:Between January 2008 and March 2012, 3041 patients underwent RARP at our institution by a single surgeon (V.P.). In all, 44 patients were considered ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2013.11798.x
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and what does the study add?: Variations in the type of urinary diversion exist for patients undergoing radical cystectomy. Although its use has been increasing from 2001 to 2008, patients who are older, female, and primary insured by Medicaid are less likely to receive continent...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11508.x
更新日期:2013-08-01 00:00:00
abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08696.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To assess, in a retrospective study, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and the combination of both in unilateral clinical T3a (cT3a) prostate cancer. PATIENTS AND METHODS:Th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06452.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of ciprofloxacin 500 mg orally twice daily with pivampicillin 700 mg orally twice daily for 10 days in men with acute epididymitis and over 40 years of age. PATIENTS AND METHODS:The study comprised 172 men who entered a prospective, controlled, randomized, double-blind, tri...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1046/j.1464-410x.1999.00252.x
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To determine whether health-insurance status might result in more localized stage at presentation, more favourable stage at surgery and in a lower rate of biochemical recurrence (BCR), in patients diagnosed with prostate cancer and treated with radical prostatectomy (RP), as despite uninhibited access to heal...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.06771.x
更新日期:2007-06-01 00:00:00