Abstract:
OBJECTIVES:To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS:Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS:A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION:This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
journal_name
BJU Intjournal_title
BJU internationalauthors
Bancroft EK,Saya S,Page EC,Myhill K,Thomas S,Pope J,Chamberlain A,Hart R,Glover W,Cook J,Rosario DJ,Helfand BT,Hutten Selkirk C,Davidson R,Longmuir M,Eccles DM,Gadea N,Brewer C,Barwell J,Salinas M,Greenhalgh L,Tdoi
10.1111/bju.14412subject
Has Abstractpub_date
2019-02-01 00:00:00pages
284-292issue
2eissn
1464-4096issn
1464-410Xjournal_volume
123pub_type
杂志文章abstract::• Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. • If this is not possible on imaging criteria then biopsy can...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11618.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of low-dose rate prostate brachytherapy on the sexual health of men with > or = 7 years of prospective evaluation and optimum sexual function before treatment. PATIENTS AND METHODS:In all, 223 patients with T1b to T3a prostate cancer and a median (range) age of 66 (50-82) years were tr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07016.x
更新日期:2007-08-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11432.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:To assess the activity of baclofen, a potent gamma-aminobutyric acid-ergic agonist, against dysfunctional voiding (DV) and lower urinary tract symptoms (LUTS) in a clinical trial, as DV is a leading cause of LUTS in women, but there is no effective treatment. PATIENTS AND METHODS:We conducted a randomized d...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.06987.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To review our experience of percutaneous nephrolithotomy (PCNL) in children before school age, and determine its efficacy and safety in this age group. PATIENTS AND METHODS:The records of children aged < or = 5 years undergoing PCNL were reviewed. Variables assessed included stone number, size, location and ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05173.x
更新日期:2004-12-01 00:00:00
abstract::A detailed history, physical examination, symptom and quality-of-life assessment, and urine analysis are unanimously considered essential components of the initial evaluation of urinary incontinence. Beyond these assessments, there are no universally accepted recommendations and, to date, imaging is not recommended in...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2005.05433.x
更新日期:2005-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after definitive local therapy. The objective of our present study was to summarise available evid...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2012.11527.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:To determine the effects of LRIG1 on the growth, migration and invasion of bladder cancer cells and the mechanisms underlying such effects. MATERIALS AND METHODS:The plasmid pLRIG1-green fluorescence protein (GFP) was transfected into BIU87 bladder cancer cells by Lipofectamine2000 (Invitrogen, Groningen, t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06405.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of patients with and without positive surgical margins (PSMs) and to analyse the impact of PSMs on secondary cancer treatment after radical prostatectomy (RP), with short-term follow-up. PATIENTS AND METHODS:We analysed data from 2385 consecutive patients treated using RP, who...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12509
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:•To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS:•At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10207.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between International Continence Society categories of lower urinary tract symptoms (LUTS; storage, voiding, and postmicturition) and individual LUTS (associated with decreased sexual activity and sexual satisfaction in men) with erectile dysfunction (ED), ejaculatory dysfunction (...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08447.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2009.08196.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.13474
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (SEPs) after electrical stimulation of different locations in the lower urinary tract (LUT) in a cohort of middle-aged healthy women. SUBJECTS AND METHODS:In a group of 10 healthy middle-aged women [mean (sd...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13066
更新日期:2015-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? In the 1980s and 1990s, a method for direct measurement of pressure and cross-sectional area in women and men was developed. It was successful in terms of obtaining meaningful results in several studies. But the technique, which was based on the field...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10997.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07068.x
更新日期:2007-11-01 00:00:00
abstract::What's known on the subject? and What does the study add? With recent improvements in the prognosis for patients with metastatic renal cell carcinoma (mRCC), focus is now shifting towards maximising clinical benefit from targeted therapies. Factors other than efficacy data are increasingly being considered when select...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11100.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the conservative management of encrusted pyelitis (EP), an infectious disease caused by urea-splitting micro-organisms (Corynebacterium group D2 being the most common), and characterized by stone encrustation of the collecting system. PATIENTS AND METHODS:Four patients (aged 17-62 years) with EP ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00156.x
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To investigate the frequency and spectrum of lipophilic Malassezia yeasts within the area of the glans penis and preputial space in healthy men, most of whom were uncircumcised. SUBJECTS AND METHODS:As the glans penis and the prepuce are abundant in sebaceous glands, 130 clinically healthy men were examined ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02375.x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:To explore the role of transient receptor potential vanilloid 1 (TRPV1) in the excitatory effects of chronic administration of nerve growth factor (NGF) on bladder-generated sensory input and reflex activity. To explore new therapeutic targets for bladder dysfunction. MATERIALS AND METHODS:Wild-type (WT) an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11187.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07362.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To evaluate if the obesity paradox, wherein obesity portends worse overall prognosis for a disease but improved outcomes for patients receiving immunotherapy, exists for patients receiving bacillus Calmette-Guérin (BCG) in a contemporary cohort. PATIENTS AND METHODS:We performed an Institutional Review Boar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15296
更新日期:2020-11-14 00:00:00
abstract:OBJECTIVE:To evaluate the justification for operative intervention in patients undergoing surgery for benign scrotal pathology, and to assess the associated morbidity. PATIENTS AND METHODS:Consecutive patients in two surgical firms who underwent surgery for benign intrascrotal pathology over a 5-year period were studi...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2001.02276.x
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:To analyse functional outcomes and complication rates of artificial urinary sphincter (AUS) implantation with a distal bulbar double cuff (DC) for the treatment of stress urinary incontinence (SUI) in men with and without a history of external beam radiotherapy (RT). PATIENTS AND METHODS:Data of all patient...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14882
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of a genomic classifier (GC) test for predicting metastasis risk after radical prostatectomy (RP) on urologists' decision-making about adjuvant treatment of patients with high-risk prostate cancer. SUBJECTS AND METHODS:Patient case history was extracted from the medical records of eac...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12789
更新日期:2015-03-01 00:00:00
abstract::For the delivery of good-quality external beam radiotherapy (EBRT) in localized prostate cancer, under-dosage to the peripheral zone (tumour) is one likely cause of poor results. The quality is improved by daily verification of the position of the prostate, and the use of magnetic resonance imaging (MRI) in delineatio...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07346.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical significance of hypertension (HTN), neutropaenia and thrombocytopaenia as possible new biomarkers of sunitinib efficacy in non-trial patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:In all, 181 consecutive patients with mRCC were treated with sunitinib; 39 ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12940
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:• To compare outcomes of hilar clamping and non-hilar clamping partial nephrectomy for tumours involving a solitary functional kidney. PATIENTS AND METHODS:• Between 1990 and 2009, 104 partial nephrectomies, excluding bench and autotransplant procedures, were performed on solitary functional kidneys. • An in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09713.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:• To investigate the relationship between pretreatment testosterone levels and pathological specimen characteristics, by prospectively examining serum androgen concentrations in a well-studied cohort of patients who underwent radical prostatectomy (RP) for localized prostate cancer. PATIENTS AND METHODS:• A ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09816.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To determine whether very small prostate cancers present in patients who also have lymph node (LN) metastases represent a particularly aggressive disease variant compared with larger LN-positive tumours. PATIENTS AND METHODS:We identified 37 501 patients diagnosed with prostate cancer between 1988 and 2001 t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13248
更新日期:2016-08-01 00:00:00