Abstract:
OBJECTIVE:To determine whether very small prostate cancers present in patients who also have lymph node (LN) metastases represent a particularly aggressive disease variant compared with larger LN-positive tumours. PATIENTS AND METHODS:We identified 37 501 patients diagnosed with prostate cancer between 1988 and 2001 treated with radical prostatectomy within the Surveillance, Epidemiology, and End Results database. The primary study variables were tumour size by largest dimension (stratified into: (i) microscopic focus only or 1 mm; (ii) 2-15 mm; (iii) 16-30 mm; (iv) >30 mm), regional LN involvement, and the corresponding interaction term. We evaluated the risk of 10-year prostate cancer-specific mortality (PCSM) using the Fine and Gray model for competing risks after controlling for race, tumour grade, T stage, receipt of radiation, number of dissected LNs, number of positive LNs, year of diagnosis, and age at diagnosis. RESULTS:The median follow-up was 11.8 years. There was a significant interaction between tumour size and LN involvement (P-interaction <0.001). In the absence of LN involvement (36 561 patients), the risk of 10-year PCSM increased monotonically with increasing tumour size. Among patients with LN involvement (940), those with the smallest tumours had increased 10-year PCSM compared with patients with tumours sized 2-15 mm (24.7% vs 11.8%; adjusted hazard ratio [AHR] 2.84, 95% confidence interval [CI] 1.21-6.71; P = 0.017) or 16-30 mm (24.7% vs 15.5%; AHR 3.12, 95% CI 1.51-6.49; P = 0.002), and similar 10-year PCSM as those with tumours >30 mm (24.7% vs 24.9%; P = 0.156). CONCLUSION:In patients with prostate cancer with LN involvement, very small tumour size may predict for higher PCSM compared with some larger tumours, even after controlling for other prognostic variables. These tumours might be particularly aggressive, beyond what is captured by pathological assessment of tumour grade and stage.
journal_name
BJU Intjournal_title
BJU internationalauthors
Muralidhar V,Mahal BA,Nezolosky MD,Beard CJ,Feng FY,Martin NE,Efstathiou JA,Choueiri TK,Pomerantz MM,Sweeney CJ,Trinh QD,Vander Heiden MG,Nguyen PLdoi
10.1111/bju.13248subject
Has Abstractpub_date
2016-08-01 00:00:00pages
279-85issue
2eissn
1464-4096issn
1464-410Xjournal_volume
118pub_type
杂志文章abstract:OBJECTIVES:To investigate the associations of host metabolic factors and metabolic syndrome on prostate cancer-specific death (PCSD) and overall survival (OS) in patients treated with androgen deprivation therapy (ADT) for biochemically recurrent disease. PATIENTS AND METHODS:The analysis included 273 patients with pr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13428
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00075.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To investigate the extent to which different types of bladder dysfunction can affect long-term renal function in boys with posterior urethral valves (PUV). PATIENTS AND METHODS:Renal and bladder function were retrospectively assessed in 59 boys with PUV (mean age 10 years, range 5-17). All patients included ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02881.x
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To assess the extent to which prostate HistoScanning (PHS), a new ultrasound-based technology that uses computer-aided analysis to quantify tissue disorganization induced by malignant processes, can identify and characterize foci of prostate cancer compared with step-sectioned radical prostatectomy (RP) speci...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07232.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To determine patient satisfaction and experience after robot-assisted radical prostatectomy (RARP) for prostate cancer, using a convergent mixed-method qualitative analysis approach. PATIENTS AND METHODS:412 patients who underwent RARP between January 2014 and June 2016 were mailed questionnaires and invited...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14226
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00010.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To determine the influence of radiotherapy on the outcome of artificial urinary sphincter implantation. PATIENTS AND METHODS:A series of 72 men who had an artificial urinary sphincter inserted were reviewed retrospectively, analysing in detail the information from 15 patients with a past history of pelvic ra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS:The review was performed according to the Preferred Reporting Items for Systematic Reviews...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.13759
更新日期:2017-04-01 00:00:00
abstract:UNLABELLED:Authors from Iowa City report on the incidence of RCC; they compared the rate of these tumours at autopsy and felt that the decrease found was a result of better antemortem detection, and an increase with time in the frequency of clinically detected renal cancer. A study from New York attempted to determine ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05244.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To present our initial operative experience in which single-port-light endoscopic robot-assisted reconstructive and extirpative urological surgery was performed by one surgeon, using a pig model. MATERIALS AND METHODS:This pilot study was conducted in male farm pigs to determine the feasibility and safety o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08955.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To examine national trends in the medical and surgical treatment of benign prostatic hyperplasia (BPH) using Australian Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) population data from 2000 to 2018. PATIENTS AND METHODS:Annual data was extracted from the MBS, PBS and Australian ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15098
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the predictive value of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) for an unsampled prostate cancer on an extended biopsy is lower due to more thorough prostate sampling, and whether the proportion of cores with HGPIN is associated with prostate cancer, as isolated HG...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06681.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:• To determine (i) the presence of fatty acid amide hydrolase (FAAH) in the urinary bladder; (ii) whether or not endogenous fatty acid ethanolamides are synthesized by the bladder; (iii) the effects of FAAH inhibition on referred hyperalgesia associated with acute bladder inflammation in rats. MATERIALS AND ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09583.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety and efficacy of stereotactic radiotherapy (SRT) in patients with metastatic renal cell carcinoma (mRCC) concurrently receiving targeted therapy (TT) or immunotherapy. PATIENTS AND METHODS:Data on patients with mRCC were extracted from a retrospective international multicentre register...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15284
更新日期:2020-10-28 00:00:00
abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04020.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To determine the concentration of nitric oxide (NO) and the location and change in the expression of NO synthase (NOS) isoforms in the testes of subfertile men with varicocele, and to compare the NO concentration or NOS expression with clinical variables, to determine the role of NO on the pathophysiology of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06800.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To validate high-sensitivity C-reactive protein (hs-CRP) serum levels as an independent marker for disease-free survival (DFS) in clinically localised clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:In all, 403 consecutive patients with clinically localised (T1-3N0M0) ccRCC treated by radical o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12067
更新日期:2013-06-01 00:00:00
abstract::For the delivery of good-quality external beam radiotherapy (EBRT) in localized prostate cancer, under-dosage to the peripheral zone (tumour) is one likely cause of poor results. The quality is improved by daily verification of the position of the prostate, and the use of magnetic resonance imaging (MRI) in delineatio...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07346.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To develop and test the safety and feasibility of a novel anti-biofilm mechanism configured for wireless capsule endoscopy (WCE) in a sheep bladder model. MATERIALS AND METHODS:A WCE mechanism, designed for long-term bladder monitoring, was developed and introduced into a sheep bladder for 5 months. The tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12040
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effect on cancer detection by varying the number of cores taken for prostate biopsy according to the size of the prostate. PATIENTS AND METHODS:A retrospective review of a prospectively registered prostate biopsy database identified 3040 consecutive patients undergoing prostate biopsy at a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10239.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...
journal_title:BJU international
pub_type: 杂志文章,meta分析
doi:10.1111/j.1464-410X.2004.05255.x
更新日期:2005-01-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10848.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:• Obesity induced by high-fat diet (HFD) is one of the most important risk factor for the development of erectile dysfunction (ED) in man. This study aimed to characterize the ED resulting from obesity associated with HFD in mice. MATERIALS AND METHODS:• C57BL/6 mice fed for 10 weeks with either HFD to induc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09704.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC). PATIENTS, SUBJECTS AND METHODS:The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC. N-glycan shows reduced levels of high molecular weight ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08163.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of detrusor instability (DI) detected by conventional and ambulatory bladder pressure monitoring, any link between urodynamic findings before and after colposuspension, and between patients' symptoms and the urodynamic findings. PATIENTS AND METHODS:Sixty-five patients, scheduled t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00390.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14998
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological asses...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09442.x
更新日期:2011-01-01 00:00:00