Abstract:
OBJECTIVES:To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS:The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of the Cochrane register, Embase, Medline, Scopus (last search on 11 November 2016). RESULTS:After screening 8 469 articles, we included two randomized controlled trials and one open-label study, in which a total of 426 patients were enrolled. Cannabinoids relevantly decreased the number of incontinence episodes in all three studies. Pooling data showed the mean difference in incontinence episodes per 24 h to be -0.35 (95% confidence interval -0.46 to -0.24). Mild adverse events were frequent (38-100%), but only two patients (0.7%) reported a serious adverse event. CONCLUSIONS:Preliminary data imply that cannabinoids might be an effective and safe treatment option for NLUTD in patients with MS; however, the evidence base is poor and more high-quality, well-designed and adequately powered and sampled studies are urgently needed to reach definitive conclusions.
journal_name
BJU Intjournal_title
BJU internationalauthors
Abo Youssef N,Schneider MP,Mordasini L,Ineichen BV,Bachmann LM,Chartier-Kastler E,Panicker JN,Kessler TMdoi
10.1111/bju.13759subject
Has Abstractpub_date
2017-04-01 00:00:00pages
515-521issue
4eissn
1464-4096issn
1464-410Xjournal_volume
119pub_type
杂志文章,meta分析,评审abstract:OBJECTIVES:To investigate the long-term functional outcomes and complications after continent cutaneous diversion with the Lundiana pouch. PATIENTS AND METHODS:Complications, re-operations, renal function, and continence were ascertained from patient charts. Outcome variables were validated by a second and independent...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
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journal_title:BJU international
pub_type: 杂志文章
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abstract:OBJECTIVE:To examine the incidence and time trends of secondary bladder cancer (BCa) and rectal cancer (RCa) after brachytherapy (BT) relative to radical prostatectomy (RP). MATERIALS AND METHODS:Within the Surveillance, Epidemiology and End Results (SEER) database (1988-2015), we identified patients with localized PC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14841
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abstract:OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer t...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2010.09273.x
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pub_type: 杂志文章
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journal_title:BJU international
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journal_title:BJU international
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abstract:OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07068.x
更新日期:2007-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2009.08422.x
更新日期:2009-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07735.x
更新日期:2008-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08232.x
更新日期:2009-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00668.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Tr...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12542
更新日期:2014-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2002.02674.x
更新日期:2002-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06681.x
更新日期:2007-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10114.x
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-4096.2004.04832.x
更新日期:2004-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11766.x
更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00997.x
更新日期:2001-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02212.x
更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14861
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To explore whether the number of unfavourable pretreatment risk factors predicts cause-specific mortality in men treated with prostate brachytherapy. PATIENTS AND METHODS:Between April 1995 and March 2006, 739 patients were treated who had at least one of the following adverse risk factors: pretreatment pros...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09269.x
更新日期:2010-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13979
更新日期:2018-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13334
更新日期:2016-05-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2019-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08984.x
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1111/j.1464-410X.2005.05454.x
更新日期:2005-05-01 00:00:00