Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: a systematic review and meta-analysis.

Abstract:

OBJECTIVES:To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS:The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of the Cochrane register, Embase, Medline, Scopus (last search on 11 November 2016). RESULTS:After screening 8 469 articles, we included two randomized controlled trials and one open-label study, in which a total of 426 patients were enrolled. Cannabinoids relevantly decreased the number of incontinence episodes in all three studies. Pooling data showed the mean difference in incontinence episodes per 24 h to be -0.35 (95% confidence interval -0.46 to -0.24). Mild adverse events were frequent (38-100%), but only two patients (0.7%) reported a serious adverse event. CONCLUSIONS:Preliminary data imply that cannabinoids might be an effective and safe treatment option for NLUTD in patients with MS; however, the evidence base is poor and more high-quality, well-designed and adequately powered and sampled studies are urgently needed to reach definitive conclusions.

journal_name

BJU Int

journal_title

BJU international

authors

Abo Youssef N,Schneider MP,Mordasini L,Ineichen BV,Bachmann LM,Chartier-Kastler E,Panicker JN,Kessler TM

doi

10.1111/bju.13759

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

515-521

issue

4

eissn

1464-4096

issn

1464-410X

journal_volume

119

pub_type

杂志文章,meta分析,评审
  • Long-term third-party assessment of results after continent cutaneous diversion with Lundiana pouch.

    abstract:OBJECTIVES:To investigate the long-term functional outcomes and complications after continent cutaneous diversion with the Lundiana pouch. PATIENTS AND METHODS:Complications, re-operations, renal function, and continence were ascertained from patient charts. Outcome variables were validated by a second and independent...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13863

    authors: Liedberg F,Gudjonsson S,Xu A,Bendahl PO,Davidsson T,Månsson W

    更新日期:2017-10-01 00:00:00

  • Long-term functional and morphological outcome after pyeloplasty for huge renal pelvis.

    abstract:OBJECTIVE:• To evaluate the functional and morphological outcome after open pyeloplasty for ureteropelvic junction obstruction (UPJO) with huge renal pelvis. PATIENTS AND METHODS:• A retrospective review of all cases who underwent pyeloplasty for huge renal pelvis was conducted. • Records were evaluated with respect t...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09566.x

    authors: Sarhan O,Helmy T,Abou-El Ghar M,Baky MA,El-Assmy A,Dawaba M

    更新日期:2011-03-01 00:00:00

  • Long-term incidence of secondary bladder and rectal cancer in patients treated with brachytherapy for localized prostate cancer: a large-scale population-based analysis.

    abstract:OBJECTIVE:To examine the incidence and time trends of secondary bladder cancer (BCa) and rectal cancer (RCa) after brachytherapy (BT) relative to radical prostatectomy (RP). MATERIALS AND METHODS:Within the Surveillance, Epidemiology and End Results (SEER) database (1988-2015), we identified patients with localized PC...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14841

    authors: Mazzone E,Mistretta FA,Knipper S,Palumbo C,Tian Z,Pecoraro A,Preisser F,Gallina A,Shariat SF,Saad F,Graefen M,Montorsi F,Briganti A,Karakiewicz PI

    更新日期:2019-12-01 00:00:00

  • Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or stroke.

    abstract:OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer t...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2010.09273.x

    authors: Hayes JH,Chen MH,Moran BJ,Braccioforte MH,Dosoretz DE,Salenius S,Katin MJ,Ross R,Choueiri TK,D'Amico AV

    更新日期:2010-10-01 00:00:00

  • Safety and feasibility of early single-dose mitomycin C bladder instillation after robot-assisted radical nephroureterectomy.

    abstract:OBJECTIVES:To assess the safety and feasibility of early single-dose mitomycin C (MMC) bladder instillation after robot-assisted radical nephroureterectomy (RARNU) at a tertiary kidney cancer centre. RARNU with bladder cuff excision and subsequent MMC bladder instillation to reduce recurrence risk is the 'gold standard...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.15162

    authors: Gulamhusein A,Silva P,Cullen D,Tran M,Mumtaz F,Patki P,Barod R,Bex A

    更新日期:2020-12-01 00:00:00

  • Cancer ablation with regional templates applied to prostatectomy specimens from men who were eligible for focal therapy.

    abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08359.x

    authors: Ward JF,Nakanishi H,Pisters L,Babaian RJ,Troncoso P

    更新日期:2009-08-01 00:00:00

  • Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine.

    abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04020.x

    authors: Nutt JE,Durkan GC,Mellon JK,Lunec J

    更新日期:2003-01-01 00:00:00

  • Cavernous nerve graft reconstruction using an autologous nerve guide to restore potency.

    abstract:OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07068.x

    authors: Fujioka M,Tasaki I,Kitamura R,Yakabe A,Hayashi M,Matsuya F,Miyaguchi T,Tsuruta J

    更新日期:2007-11-01 00:00:00

  • Acupuncture for treating erectile dysfunction: a systematic review.

    abstract:OBJECTIVE:We evaluated the current evidence for the use of acupuncture to treat erectile dysfunction (ED). METHODS:Systematic searches were conducted in 15 electronic databases, with no language restrictions. Hand-searches included conference proceedings and our files. All clinical studies of acupuncture as a treatmen...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1464-410X.2009.08422.x

    authors: Lee MS,Shin BC,Ernst E

    更新日期:2009-08-01 00:00:00

  • Risk factors associated with renal parenchymal fracture during laparoscopic cryoablation.

    abstract:OBJECTIVE:To assess the risk factors for haemorrhage and renal fracture associated with renal cryoablation. MATERIALS AND METHODS:In a porcine model, 120 cryoablations were administered in 26 pigs, with five groups of 24 ice-balls each; in groups 1 and 2 asynchronous cryoprobe activation was evaluated for the 1.47- an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07735.x

    authors: Hruby G,Edelstein A,Karpf J,Durak E,Phillips C,Lehman D,Landman J

    更新日期:2008-09-01 00:00:00

  • Validation of serum C-reactive protein (CRP) as an independent prognostic factor for disease-free survival in patients with localised renal cell carcinoma (RCC).

    abstract:OBJECTIVE:To validate high-sensitivity C-reactive protein (hs-CRP) serum levels as an independent marker for disease-free survival (DFS) in clinically localised clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:In all, 403 consecutive patients with clinically localised (T1-3N0M0) ccRCC treated by radical o...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12067

    authors: de Martino M,Klatte T,Seemann C,Waldert M,Haitel A,Schatzl G,Remzi M,Weibl P

    更新日期:2013-06-01 00:00:00

  • An update on experience with the single-instrument port laparoscopic nephrectomy.

    abstract:OBJECTIVE:To describe a modification of the posterior prone retroperitoneoscopic nephrectomy, which allows the entire operation to be performed through a single instrument port. PATIENTS AND METHODS:With the patient prone, a retroperitoneal working space is created using a custom-made balloon lateral to the sacrospina...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08232.x

    authors: Msezane LP,Mushtaq I,Gundeti MS

    更新日期:2009-05-01 00:00:00

  • Comparison of modified one- and two-layer microsurgical vasovasostomy.

    abstract:OBJECTIVE:To compare the outcome of a modified one-layer and two-layer vasovasotomy (VV) in two groups of similar men undergoing vasectomy reversal. PATIENTS AND METHODS:The charts and surgical records of all surgical procedures performed on men undergoing a modified one- or two-layer VV between June 1992 and July 199...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00668.x

    authors: Fischer MA,Grantmyre JE

    更新日期:2000-06-01 00:00:00

  • Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer.

    abstract:OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Tr...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.12542

    authors: Martínez-Piñeiro L,Schalken JA,Cabri P,Maisonobe P,de la Taille A,Triptocare Study Group.

    更新日期:2014-10-01 00:00:00

  • Re-auditing a regional lithotripsy service.

    abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-410x.2002.02674.x

    authors: Parkin J,Keeley FX Jr,Timoney AG

    更新日期:2002-05-01 00:00:00

  • The proportion of cores with high-grade prostatic intraepithelial neoplasia on extended-pattern needle biopsy is significantly associated with prostate cancer on site-directed repeat biopsy.

    abstract:OBJECTIVE:To determine whether the predictive value of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) for an unsampled prostate cancer on an extended biopsy is lower due to more thorough prostate sampling, and whether the proportion of cores with HGPIN is associated with prostate cancer, as isolated HG...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06681.x

    authors: Akhavan A,Keith JD,Bastacky SI,Cai C,Wang Y,Nelson JB

    更新日期:2007-04-01 00:00:00

  • The economics of robotic cystectomy: cost comparison of open versus robotic cystectomy.

    abstract:OBJECTIVE:• To assess and compare the economic burden of open radical cystectomy (OC) vs robotic-assisted laparoscopic radical cystectomy (RC) with pelvic lymph node dissection and urinary diversion. PATIENTS AND METHODS:• A series of 103 and 83 consecutive patients undergoing OC and RC, respectively, were prospective...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10114.x

    authors: Lee R,Ng CK,Shariat SF,Borkina A,Guimento R,Brumit KF,Scherr DS

    更新日期:2011-12-01 00:00:00

  • The significance of the expression of dihydropyrimidine dehydrogenase in prostate cancer.

    abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06606.x

    authors: Li Y,Mizutani Y,Shiraishi T,Nakamura T,Mikami K,Takaha N,Okihara K,Kawauchi A,Sakai T,Miki T

    更新日期:2007-03-01 00:00:00

  • Rates of prostate-specific antigen testing in general practice in England and Wales in asymptomatic and symptomatic patients: a cross-sectional study.

    abstract:OBJECTIVE:To assess the rate of prostate-specific antigen (PSA) testing for prostate cancer in general practice in asymptomatic and symptomatic patients. SUBJECTS AND METHODS:The cross-sectional study took place in England and Wales, was population-based and covered 469 159 men aged 45-84 years. Pathology data on PSA ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-4096.2004.04832.x

    authors: Melia J,Moss S,Johns L,Contributors in the participating laboratories.

    更新日期:2004-07-01 00:00:00

  • Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy.

    abstract:UNLABELLED:What's known on the subject? and what does the study add?: As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11766.x

    authors: Oh JJ,Jeong SJ,Lee BK,Jeong CW,Byun SS,Hong SK,Lee SE

    更新日期:2013-08-01 00:00:00

  • Direct comparison of radiology and nuclear medicine cystograms in young infants with vesico-ureteric reflux.

    abstract:OBJECTIVE:To determine the sensitivity of the direct radionuclide cystogram (DRC) in detecting vesico-ureteric reflux compared with the micturating cysto-urethrogram (MCU) in the same initial setting, in infants younger than one year. PATIENTS AND METHODS:The results from the dual cystograms of 62 refluxing infants < ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.00997.x

    authors: McLaren CJ,Simpson ET

    更新日期:2001-01-01 00:00:00

  • The prevalence of loss of heterozygosity in chromosome 3, including FHIT, in bladder cancer, using the fluorescent multiplex polymerase chain reaction.

    abstract:OBJECTIVE:To determine some of the genetic alterations involved in the pathogenesis and progression of transitional cell carcinoma of the bladder. Materials and methods In a population-based study, freshly frozen tissue was collected from all patients newly diagnosed with urinary bladder cancer in the Stockholm region ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02212.x

    authors: Wada T,Louhelainen J,Hemminki K,Adolfsson J,Wijkström H,Norming U,Borgström E,Hansson J,Steineck G

    更新日期:2001-06-01 00:00:00

  • Testicular-sparing surgery for bilateral or monorchide testicular tumours: a multicenter study of long-term oncological and functional results.

    abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.12549

    authors: Ferretti L,Sargos P,Gross-Goupil M,Izard V,Wallerand H,Huyghe E,Rigot JM,Durand X,Benoit G,Ferriere JM,Droupy S

    更新日期:2014-12-01 00:00:00

  • Radical cystectomy pentafecta: a proposal for standardisation of outcomes reporting following robot-assisted radical cystectomy.

    abstract:OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary di...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14861

    authors: Cacciamani GE,Winter M,Medina LG,Ashrafi AN,Miranda G,Tafuri A,Landsberger H,Lin-Brande M,Rajarubendra N,De Castro Abreu A,Berger A,Aron M,Gill IS,Desai MM

    更新日期:2020-01-01 00:00:00

  • Relationship between prostate cancer mortality and number of unfavourable risk factors in men treated with definitive brachytherapy.

    abstract:OBJECTIVE:To explore whether the number of unfavourable pretreatment risk factors predicts cause-specific mortality in men treated with prostate brachytherapy. PATIENTS AND METHODS:Between April 1995 and March 2006, 739 patients were treated who had at least one of the following adverse risk factors: pretreatment pros...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09269.x

    authors: Taira AV,Merrick GS,Galbreath RW,Butler WM,Lief JH,Wallner KE

    更新日期:2010-09-01 00:00:00

  • Serous-lined, stapled pouch wall plication: initial results of a simple and quick novel continence mechanism in troubleshooting secondary to continent cutaneous urinary diversion.

    abstract:OBJECTIVES:To report a novel and straightforward technique of a secondary continent outlet for continent cutaneous urinary diversion (CCUD) reservoirs without the need for further bowel resection, reducing operating time and length of hospitalization. PATIENTS AND METHODS:From 2015 to 2017, six patients with unreconst...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13979

    authors: Riedmiller H,Kocot A,Kalogirou C

    更新日期:2018-01-01 00:00:00

  • Prevalence of metabolic syndrome and its components among men with and without clinical benign prostatic hyperplasia: a large, cross-sectional, UK epidemiological study.

    abstract:OBJECTIVES:To compare the prevalence of metabolic syndrome and the components of metabolic syndrome in men aged ≥50 years with and without clinical benign prostatic hyperplasia (BPH). SUBJECTS AND METHODS:This was a cross-sectional study using the UK Clinical Practice Research Datalink (CPRD). Men were selected from t...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13334

    authors: DiBello JR,Ioannou C,Rees J,Challacombe B,Maskell J,Choudhury N,Kastner C,Kirby M

    更新日期:2016-05-01 00:00:00

  • Aquablation for benign prostatic hyperplasia in large prostates (80-150 mL): 6-month results from the WATER II trial.

    abstract:OBJECTIVE:To present 6-month safety and effectiveness data from a multicentre prospective study of aquablation in men with lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) with prostate volumes between 80 and 150 mL. METHODS:Between September and December 2017, 101 men with LUTSat...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/bju.14703

    authors: Desai M,Bidair M,Zorn KC,Trainer A,Arther A,Kramolowsky E,Doumanian L,Elterman D,Kaufman RP Jr,Lingeman J,Krambeck A,Eure G,Badlani G,Plante M,Uchio E,Gin G,Goldenberg L,Paterson R,So A,Humphreys M,Roehrborn C,K

    更新日期:2019-08-01 00:00:00

  • Development and validation of an Arabic version of the International Prostate Symptom Score.

    abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08984.x

    authors: Hammad FT,Kaya MA

    更新日期:2010-05-01 00:00:00

  • A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder.

    abstract:OBJECTIVE:To evaluate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), from an analysis of pooled data from three phase III, multicentre, double-blind clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:After a 4-week washout/run-...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1464-410X.2005.05454.x

    authors: Chapple C,Steers W,Norton P,Millard R,Kralidis G,Glavind K,Abrams P

    更新日期:2005-05-01 00:00:00