Abstract:
OBJECTIVE:To explore whether the number of unfavourable pretreatment risk factors predicts cause-specific mortality in men treated with prostate brachytherapy. PATIENTS AND METHODS:Between April 1995 and March 2006, 739 patients were treated who had at least one of the following adverse risk factors: pretreatment prostate-specific antigen (PSA) level of >10 ng/mL, a Gleason score of > or =7, clinical stage > or =T2b, or a PSA velocity (PSAV) of >2 ng/mL/year. Supplemental external beam radiotherapy (EBRT) was delivered to 464 (62.8%) men and 301 (40.7%) received androgen deprivation therapy (ADT). Of men with more than two risk factors, 87% received EBRT and 62% received ADT. RESULTS:The biochemical progression-free survival (bPFS), cause-specific survival (CSS) and overall survival for all patients were 95.0%, 97.9% and 70.0% at 12 years. Men with three or four risk factors had a prostate cancer-specific mortality (PCSM) at 12 years of 5.3%, vs 1.7% for men with one or two risk factors (P= 0.006). When 'percentage of positive biopsy cores >50%' replaced PSAV as a risk factor, men with two or more risk factors had a PCSM of 8.9%, vs 1.0% for men with one or two risk factors (P= 0.001). There was no difference in all-cause mortality between the groups in either analysis. CONCLUSION:Multimodal brachytherapy results in high rates of bPFS and CSS, even for men with several unfavourable risk factors. Men with two or more unfavourable risk factors had a slightly greater risk of PCSM and no difference in all-cause mortality. The presence of three or four unfavourable intermediate-risk factors does not appear to clearly identify a group that requires further treatment intensification, although the percentage of positive cores might be more predictive than PSAV.
journal_name
BJU Intjournal_title
BJU internationalauthors
Taira AV,Merrick GS,Galbreath RW,Butler WM,Lief JH,Wallner KEdoi
10.1111/j.1464-410X.2010.09269.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
809-14issue
6eissn
1464-4096issn
1464-410Xpii
BJU9269journal_volume
106pub_type
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journal_title:BJU international
pub_type: 杂志文章
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abstract:OBJECTIVE:To present the results of the first clinical study of a synchronous twin-pulse technique for extracorporeal shock-wave lithotripsy (ESWL), which is effective for in vitro stone fragmentation and safe when assessed in vivo on animal tissue. PATIENTS AND METHODS:Fifty patients with urinary stones (35 men and 1...
journal_title:BJU international
pub_type: 临床试验,杂志文章
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abstract:OBJECTIVE:To report a contemporary series of patients with xanthogranulomatous pyelonephritis (XGP, an inflammatory condition of the kidney that has traditionally been treated with open nephrectomy, ON), managed with either ON or laparoscopic nephrectomy (LN), as early reports suggest that the benefits of LN do not ext...
journal_title:BJU international
pub_type: 杂志文章
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abstract::OBJECTIVE To investigate the incidence of new-onset diabetes mellitus (NODM) and of worsening glycaemic control in established DM after starting androgen-deprivation therapy (ADT) for prostate cancer, as ADT is associated with altered body composition, potentially influencing insulin sensitivity. PATIENTS AND METHODS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07184.x
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abstract:OBJECTIVE:To determine the adequacy of T2 prostate cancer (PCa) sub-staging as an independent Predictor of biochemical disease-free survival (bDFS) after radical prostatectomy. MATERIALS AND METHODS:The Duke Prostate Center database was queried for patients who underwent radical prostatectomy between 1988 and 2007 and...
journal_title:BJU international
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10868.x
更新日期:2012-09-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Despite expanding treatment options for castration-resistant prostate cancer (CRPC), therapies with long response duration remain intangible due to prostate cancer cells' natural ability to develop it...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11456.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the variability of subjective tutor performance improvement (Pi) assessment and to compare it with a novel measurement algorithm: the Pi score. MATERIALS AND METHODS:The Pi-score algorithm considers time measurement and number of errors from two different repetitions (first and fifth) of the same...
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02881.x
更新日期:2002-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11316.x
更新日期:2013-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00019.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2011.10124.x
更新日期:2011-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07606.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To report the medium-term results at our institution of repairing long bulbar urethral strictures with buccal mucosal grafts. PATIENTS AND METHODS:Between January 2003 and June 2007, a buccal mucosa graft repair was used in 34 patients with recurrent bulbar strictures >2 cm. The follow-up included uroflowme...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08848.x
更新日期:2010-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05586.x
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09582.x
更新日期:2011-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04998.x
更新日期:2004-09-01 00:00:00
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更新日期:2011-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2018-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:BJU international
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doi:10.1046/j.1464-410x.2003.04429.x
更新日期:2003-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02142.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00010.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To examine the association of hospital volume and 90-day mortality after cystectomy, conditional on survival for 30 days. PATIENTS AND METHODS:The National Cancer Data Base was used to evaluate 30- and 90-day mortality for 35,055 patients who underwent cystectomy for bladder cancer at one of 1118 hospitals. ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12566
更新日期:2014-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07039.x
更新日期:2007-11-01 00:00:00