Abstract:
UNLABELLED:Study Type--Therapy (case series) Level of Evidence 4. What's known on the subject? and What does the study add? Previous reports showed controversial evidence supporting the role of sex steroids, mainly testosterone, in the etiology and pathogenesis of prostate cancer (PCa). The bioavailability of sex steroids is significantly regulated by sex hormone-binding globulin (SHBG). In this context, SHBG levels have been shown to be significantly higher in PCa patients than in controls. Likewise, SHBG was reported to serve as an independent predictor for extra-prostatic extension of tumour [defined as cancer (≥pT3) with capsular penetration, seminal vesicle involvement, or lymph node invasion (LNI)] in patients with clinically localized PCa. The presence of non-organ-confined disease is significantly associated with higher biochemical recurrence rates. This study provides novel evidence that SHBG might serve as a significant multivariate predictor of extra capsular extension (ECE) in PCa patients submitted to radical prostatectomy, after accounting for preoperative clinically available variables such as patient's age, total PSA, clinical stage, biopsy Gleason sum, and BMI. Moreover, a clinical cut-off for circulating SHBG allows using this easily quantifiable molecule as a novel clinical parameter in PCa patients. OBJECTIVE:• To examine the association between sex hormone-binding globulin (SHBG) and extracapsular extension (ECE) in men treated with retropubic radical prostatectomy (RRP). PATIENTS AND METHODS:• Preoperative serum SHBG levels were measured in a cohort of 629 consecutive European Caucasian men [mean (range) age of 64 (41-78) years] who underwent RRP. • No patient received any hormonal neoadjuvant treatment. SHBG levels were measured the day before RRP (08:00-10:00 hours) in all cases at the same laboratory. • Logistic regression models tested the association between predictors [including age, prostate-specific antigen (PSA) level, clinical stage, biopsy Gleason sum, body mass index (BMI), and SHBG] and ECE. • Combined accuracy of predictors was tested in regression-based models predicting ECE at RRP. SHBG was included in the model both as a continuous and categorized variable (according to the most informative threshold level of 30 nmol/L). RESULTS:• In all, 92 patients (14.6%) had ECE. The mean (standard deviation; median) serum SHBG levels were significantly higher in men with ECE compared with those with no ECE at 41.1 (14.7; 37.5) vs 36.4 (16.7; 34) nmol/L (P= 0.007; 95% confidence interval -8.00, -1.29). • Univariate analyses indicated that continuously coded SHBG was significantly [odds ratio (OR) 1.01; P= 0.03] associated with ECE, with a predictive accuracy of 60.1%. • At multivariate analyses, both continuous (OR 1.01; P= 0.03) and categorical SHBG (OR 3.22; P < 0.001) were significantly associated with ECE, after accounting for age, PSA level, clinical stage, biopsy Gleason sum, and BMI. • Addition of continuously coded SHBG slightly increased the predictive accuracy of the base model based on clinically established predictors from 63.3% to 65.5% (2.0% gain; P= 0.48). • In contrast, a model based on categorized-SHBG showed bootstrap-corrected predictive accuracy of 68.4% (5.1% gain; P= 0.044). CONCLUSION:• This study shows that SHBG might serve as a significant multivariate predictor of ECE in men with prostate cancer that undergo RRP.
journal_name
BJU Intjournal_title
BJU internationalauthors
Salonia A,Gallina A,Briganti A,Zanni G,Suardi N,Capitanio U,Colombo R,Bertini R,Freschi M,Guazzoni G,Rigatti P,Montorsi Fdoi
10.1111/j.1464-410X.2010.09582.xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
1243-9issue
8eissn
1464-4096issn
1464-410Xjournal_volume
107pub_type
杂志文章abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06496.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and effectiveness of the Seldinger technique by non-urology trained (NUT) doctors for difficult male indwelling urinary catheter (IDC) insertions. PATIENTS AND METHODS:In all, 115 patients and 57 participating NUT doctors were recruited by the urologist or urology registrar, when conta...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13928
更新日期:2017-11-01 00:00:00
abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.13402
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To determine whether health-insurance status might result in more localized stage at presentation, more favourable stage at surgery and in a lower rate of biochemical recurrence (BCR), in patients diagnosed with prostate cancer and treated with radical prostatectomy (RP), as despite uninhibited access to heal...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.06771.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2010.09801.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To assess the effects of testosterone supplementation in men with testosterone deficiency syndrome (TDS) after external beam radiotherapy (EBRT) for localized prostate cancer. PATIENTS AND METHODS:Five men with significant signs of TDS after treatment for localized prostate cancer with EBRT were treated with...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07882.x
更新日期:2009-01-01 00:00:00
abstract::There has been a recent increase in mumps orchitis among pubertal and postpubertal males. These outbreaks can be attributed to a reduction in the uptake of measles-mumps-rubella (MMR) vaccine during the early to mid-1990 s in children who have now matured. The mumps virus is commonly associated with extra-salivary com...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.09148.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To describe a previously unreported complication (severe perineal pain) after bladder reconstruction and enterocystoplasty in patients with bladder exstrophy. PATIENTS AND METHODS:The notes were reviewed retrospectively for four patients (two boys and two girls) with classical bladder exstrophy who had sever...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2003.04741.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:• To assess the feasibility of radical prostatectomy (RP) in a series of patients with prostate cancer with very high prostate-specific antigen (PSA) levels by comparing the clinical outcomes of different PSA thresholds (20.1-50 ng/mL, 50.1-100 ng/mL and >100 ng/mL, respectively). PATIENTS AND METHODS:• With...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10076.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To evaluate whether robotically assisted laparoscopic prostatectomy (RALP) is less invasive than radical retropubic prostatectomy (RRP), as experimental studies suggest that the acute phase reaction is proportional to surgery-induced tissue damage. PATIENTS AND METHODS:Between May and November 2006, all pat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07513.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of OnabotulinumtoxinA (BTXA) injections in men with drug-refractory non-neurogenic overactive bladder (NNOAB). PATIENTS AND METHODS:A total of 43 men received BTXA injections for NNOAB from 2004 to 2012. Patient Global Impression of Improvement (PGI-I) score was obtained. For men with ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13110
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) and fasting blood sugar (FBS), and to determine...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07774.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:• To evaluate the effect of transurethral resection of the prostate (TURP) on sexual function in the short (6 months), medium (6 years) and long (12 years) term and assess the conformity between patient and partner regarding sexual function. PATIENTS AND METHODS:• A prospective cohort study set at the Aberde...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10396.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To determine the changes in cyclooxygenase-2 (COX-2), E-cadherin and alpha-catenin expression after partial bladder outlet obstruction (PBOO), and whether a selective COX-2 inhibitor (celecoxib) might inhibit COX-2 expression and have beneficial effects on urothelial cell-to-cell interactions in rats subjecte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05359.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2002.02674.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07473.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To determine, using magnetic resonance imaging (MRI), the incidence of retropubic haematoma and any associated clinically significant effects after a xenograft (porcine dermis) sling (XS) or the tension-free vaginal tape (TVT) procedure. PATIENTS AND METHODS:Between October 2003 and March 2004, 24 consecutiv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05779.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To characterize a newly established human testicular carcinoma cell line that continuously produces alpha-fetoprotein (AFP), and to investigate the effects of retinoic acid on AFP production. MATERIALS AND METHODS:A 24-year-old man underwent a radical orchidectomy for a right testicular tumour and was found ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02357.x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To evaluate ultrasensitive (US) measurements of prostate-specific antigen (PSA) level in men with prostate cancer, and to correlate the findings with currently accepted values for PSA recurrence, as PSA is widely accepted as a surrogate marker for disease recurrence after treatment for prostate cancer, and al...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06294.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14510
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:• To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of ureteral war injury using a canine model. MATERIALS AND METHODS:• A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (G...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09992.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS:From 2002 to 2007, 1256 men ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08845.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To clarify the impact of endoscopic incision (EI) for ureterocele as an initial procedure, by performing a retrospective chart review, focusing on the prevalence of and risk factors for symptomatic urinary tract infection (UTI) after EI. MATERIALS AND METHODS:In the present study we included children with ur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13884
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To identify significant prognostic indicators of upper urinary tract (UUT) urothelial carcinoma (UC) and to assess a risk stratification of patients. PATIENTS AND METHODS:We retrospectively analysed data from 162 patients with non-metastatic UC primarily occurring in UUT treated with open nephroureterectomy....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08134.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:To compare, in a retrospective study, pathological specimens of prostate cancer detected in additional areas of a 12-core biopsy with tumours detected using traditional sextant biopsy. PATIENTS AND METHODS:The study included 27 patients who had undergone radical prostatectomy (RP) for prostate cancer. Prost...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00558.x
更新日期:2000-04-01 00:00:00
abstract::OBJECTIVE • To evaluate a novel technique to lower positive surgical margin rates while preserving as much of the neurovascular bundles as possible during nerve-sparing robotic prostatectomy. MATERIALS AND METHODS • In situ intraoperative frozen section (IFS) was performed during robotic-assisted laparoscopic prostate...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09595.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To describe and evaluate the outcomes of a new epididymovasostomy technique. PATIENTS AND METHODS:Nine patients with obstructive azoospermia were treated at the Minia University Hospital using a new microsurgical bilateral epididymovasostomy technique. The technique involved the opening of a small window in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12839
更新日期:2015-04-01 00:00:00