Abstract:
OBJECTIVE:To identify significant prognostic indicators of upper urinary tract (UUT) urothelial carcinoma (UC) and to assess a risk stratification of patients. PATIENTS AND METHODS:We retrospectively analysed data from 162 patients with non-metastatic UC primarily occurring in UUT treated with open nephroureterectomy. Variables assessed included age, gender, pT, tumour grade, tumour necrosis extension, pN, tumour location, multifocal location, tumour diameter, and subsequent development of a bladder tumour. Tumour necrosis was measured using commercial software (Eureka interface system, version 4.0.22, HESP technology, Menarini Diagnostics, Italy) and was classified as none, focal (<10% of tumour area) or extensive, >or=10% of tumour area). The prognostic significance of each variable on metastasis-free survival (MFS) and disease-free survival (DFS) was tested in univariable analysis with the log-rank test. Variables with significance levels of P < 0.05 according to the univariable analyses were entered into a multivariable forward-stepwise Cox regression model. RESULTS:At a mean follow-up of 66 months, 20 cancer-related deaths (12.3%) were censored. In multivariable analysis, tumour diameter, pT stage and tumour necrosis were independent predictors of MFS and DFS. All events occurred in patients with extensive tumour necrosis and a tumour diameter of >or=3 cm. The median survival of patients with advanced-stage tumours, extensive necrosis and a tumour diameter of >or=3 cm were significantly impaired by increasing pT stage(P < 0.001). CONCLUSION:Tumour necrosis and tumour diameter are compelling prognostic factors that deserve further study in a prospective setting to determine if their use in combination with more traditional variables, such as pT stage, might better determine prognosis and guide the follow-up and treatment of patients.
journal_name
BJU Intjournal_title
BJU internationalauthors
Simone G,Papalia R,Loreto A,Leonardo C,Sentinelli S,Gallucci Mdoi
10.1111/j.1464-410X.2008.08134.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
1052-7issue
8eissn
1464-4096issn
1464-410Xpii
BJU8134journal_volume
103pub_type
杂志文章abstract:OBJECTIVE:To examine glucose-regulated protein 78 (GRP78; a major molecular chaperone at the endoplasmic reticulum, strongly expressed in several tumours) expression in urothelial carcinoma (UC) of the upper urinary tract (UUT) and to evaluate the diagnostic and progressive importance of GRP78 expression in UC-UUT. PA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09144.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14385
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). PATIENTS AND METHODS:We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between Janu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12329
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To develop and validate an in vitro method suitable for the quantitative investigation of the growth of calcium oxalate stones through to a clinically significant size. MATERIALS AND METHODS:Small fragments of calcium oxalate calculi were suspended in a mixed suspension/mixed product removal crystalliser sup...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03027.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To prospectively investigate the presentation of germ cell tumours (GCTs) of the testis in terms of stage or histology, as the incidence of this disease in increasing. PATIENTS AND METHODS:Patients diagnosed with GCT of the testis between 1983 and 2002 were categorised into three periods depending on the dat...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05504.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. RESULTS:P...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.07173.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS:Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybri...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00654.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term follow-up (primary and secondary patency) of metal stent placement in benign ureteroileal anastomotic strictures after Bricker urinary diversion and to compare the failed treatment group with the group of successfully treated patients to search for predisposing factors of stent failu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12729
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence of bone fractures in patients receiving luteinizing hormone-releasing hormone agonists (LHRH-a) for prostate cancer (in whom a continued low testosterone level after the long-term administration of these drugs reduces bone mineral density), and thus determine the risk of secondary...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00774.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To determine the metabolic characteristics of elderly patients with recurrent calcium oxalate stones. PATIENTS AND METHODS:Metabolic abnormalities were investigated in 88 patients with recurrent calcium oxalate stones, including 70 aged <60 years and 18 aged >/=60 years. The frequency of each metabolic abnor...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00057.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of a high-oxalate/low-calcium diet on calcium oxalate stone risk factors in both black South Africans (who are largely immune to kidney stones) and white South Africans (in whom stones are more common). SUBJECTS AND METHODS:Urinary and dietary variables were examined in 11 black and...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00064.x
更新日期:2001-03-01 00:00:00
abstract::Metastases to regional lymph nodes are a common early event in many malignant diseases and have a poor prognosis, including in urological cancers. Molecular pathways contributing to lymphatic tumour dissemination and lymph node metastasis remain poorly understood. Besides the process of lymphovascular invasion (LVI), ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08704.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12732
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of >1000 men with low-risk prostate cancer treated with low-dose-rate (LDR) brachytherapy at three large UK cancer centres. PATIENTS AND METHODS:A total of 1038 patients with low-risk prostate cancer (prostate-specific antigen [PSA] ≤10 ng/mL, Gleason score 6, ≤T2b disease) were treate...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12358
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To investigate scores and predictors of patient satisfaction at 1 year after penile prosthesis implantation (PPI) using the validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. PATIENTS AND METHODS:Analyses were performed for 142 patients prospectively included in the natio...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14462
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of fluoroquinolone prophylaxis in patients undergoing transrectal ultrasonography (TRUS)-guided biopsy of the prostate in the Norwich population, and its correlation with ciprofloxacin resistance in the faecal flora. We also aimed to determine the usefulness of a pre-biopsy rectal sc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12865
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To examine the role of clean intermittent catheterization (CIC) as a possible predisposing risk factor for bladder calculi, assessing risk factors in patients with and without bladder augmentation, and to evaluate management options for bladder calculi in these patients. PATIENTS AND METHODS:The records of 4...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00625.x
更新日期:2000-05-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. What's known on the subject? and What does the study add? The indications and timing of native nephrectomy in patients with autosomal dominant polycystic kidney disease (ADPKD) is controversial, especially for those undergoing renal transplantation. P...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09938.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the levels of glycosylated haemoglobin (HbA1c) and the severity of erectile dysfunction (ED) in men with diabetes mellitus (DM). PATIENTS AND METHODS:This cross-sectional study included sexually active men with a diagnosis of DM attending a urological medical centre from J...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05349.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the effects of 50 mg mirabegron once daily for ureteric stent-related discomfort after ureteroscopic procedures by conducting a multicentre randomized study. PATIENTS AND METHODS:A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal su...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14416
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To examine a large, single-surgeon series of patients with prostate cancer who underwent retropubic radical prostatectomy (RRP) for men with postoperative bladder neck contractures (BNCs). PATIENTS AND METHODS:From 1983 to 2007, 4132 men underwent RRP for prostate cancer by one surgeon. All patients had BN r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08700.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To review the incidence of venous thromboembolism (VTE) after radical retropubic prostatectomy (RRP) and evaluate the need for heparinoid prophylaxis as opposed to mechanical compression devices after RRP. PATIENTS AND METHODS:RRP is classified as a category 1 (high risk) procedure for VTE by the American Co...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05783.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the epidemiology of lower urinary tract symptoms (LUTS) among men and women, as there are significant unanswered questions about the prevalence and impact of LUTS in different populations. SUBJECTS AND METHODS:A population-based, cross-sectional survey was completed in Boxmeer (the Netherlands), ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04369.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08167.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To determine if the biochemical composition of a renal calculus can be measured from 'dust' obtained during laser fragmentation. PATIENTS AND METHODS:This pilot study was set in a tertiary referral hospital between 2011 and 2013. Stone dust was aspirated through the ureteroscope during lasering and a stone f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13448
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC). PATIENTS, SUBJECTS AND METHODS:The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC. N-glycan shows reduced levels of high molecular weight ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08163.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To analyse the technical details and the long-term results of laparoscopic ureterolithotomy. PATIENTS AND METHODS:Laparoscopic ureterolithotomy was undertaken in 101 patients between 1991 and 2001; in only one patient with retroperitoneal fibrous adhesions was the procedure transperitoneal, being retroperito...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01562.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To externally validate the currently available nomograms for predicting lymph node invasion (LNI) in patients with prostate cancer (PCa) and to assess the potential risk of complications of extended pelvic lymph node dissection (ePLND) when using the recommended threshold. METHODS:A total of 14 921 patients...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15220
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate among radical prostatectomy (RP) patients at high-risk of recurrence whether the timing of postoperative radiation therapy (RT) (adjuvant, early salvage with detectable post-RP prostate-specific antigen [PSA], or 'late' salvage with a PSA level of >1.0 ng/mL) is significantly associated with overa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13043
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13904
更新日期:2017-09-01 00:00:00