Abstract:
OBJECTIVES:To externally validate the currently available nomograms for predicting lymph node invasion (LNI) in patients with prostate cancer (PCa) and to assess the potential risk of complications of extended pelvic lymph node dissection (ePLND) when using the recommended threshold. METHODS:A total of 14 921 patients, who underwent radical prostatectomy with ePLND at eight European tertiary referral centres, were retrospectively identified. After exclusion of patients with incomplete biopsy or pathological data, 12 009 were included. Of these, 609 had undergone multiparametic magnetic resonance imaging-targeted biopsies. Among ePLND-related complications we included lymphocele, lymphoedema, haemorrhage, infection and sepsis. The performances of the Memorial Sloan Kettering Cancer Centre (MSKCC), Briganti 2012, Briganti 2017, Briganti 2019, Partin 2016 and Yale models were evaluated using receiver-operating characteristic curve analysis (area under the curve [AUC]), calibration plots, and decision-curve analysis. RESULTS:Overall, 1158 patients (9.6%) had LNI, with a mean of 17.7 and 3.2 resected and positive nodes, respectively. No significant differences in AUCs were observed between the MSKCC (0.79), Briganti 2012 (0.79), Partin 2016 (0.78), Yale (0.80), Briganti 2017 (0.81) and Briganti 2019 (0.76) models. A direct comparison of older models showed that better discrimination was achieved with the MSKCC and Briganti 2012 nomograms. A tendency for underestimation was seen for all the older models, whereas the Briganti 2017 and 2019 nomograms tended to overestimate LNI risk. Decision-curve analysis showed a net benefit for all models, with a lower net benefit for the Partin 2016 and Briganti 2019 models. ePLND-related complications were experienced by 1027 patients (8.9%), and 12.6% of patients with pN1 disease. CONCLUSIONS:The currently available nomograms have similar performances and limitations in the prediction of LNI. Miscalibration was present, however, for all nomograms showing a net benefit. In patients with only systematic biopsy, the MSKCC and Briganti 2012 nomograms were superior in the prediction of LNI.
journal_name
BJU Intjournal_title
BJU internationalauthors
Oderda M,Diamand R,Albisinni S,Calleris G,Carbone A,Falcone M,Fiard G,Gandaglia G,Marquis A,Marra G,Parola C,Pastore A,Peltier A,Ploussard G,Roumeguère T,Sanchez-Salas R,Simone G,Smelzo S,Witt JH,Gontero Pdoi
10.1111/bju.15220subject
Has Abstractpub_date
2020-09-01 00:00:00eissn
1464-4096issn
1464-410Xpub_type
杂志文章abstract:UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10778.x
更新日期:2012-07-01 00:00:00
abstract::Since Huggins and Hodges demonstrated the responsiveness of prostate cancer to androgen deprivation therapy (ADT), androgen-suppressing strategies have formed the cornerstone of management of advanced prostate cancer. Approaches to ADT have included orchidectomy, oestrogens, luteinizing hormone-releasing hormone (LHRH...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11215.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To determine the influence of radiotherapy on the outcome of artificial urinary sphincter implantation. PATIENTS AND METHODS:A series of 72 men who had an artificial urinary sphincter inserted were reviewed retrospectively, analysing in detail the information from 15 patients with a past history of pelvic ra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To investigate the mechanisms of neurokinin A- and substance P-induced contractions of rat urinary bladder smooth muscle, and to compare them with those of the muscarinic agonist carbachol. MATERIALS AND METHODS:Rat urinary bladder strips were suspended under 1 g of tension in a physiological buffer at 37 de...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05017.x
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database. PATIENTS AND METHODS:The B...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07574.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08167.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:• To conduct a case-control study evaluating clinical symptom severity and sexual dysfunction in women with ketamine cystitis (KC). PATIENTS AND METHODS:• In total, 29 patients with KC and 27 controls completed the symptoms survey. • Participants completed a visual pelvic pain analogue scale, an O'Leary-Sant...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10780.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether fluid shear stress (FSS) induces endothelial nitric oxide synthase (eNOS) activity and NO production in isolated human corpus cavernosal endothelial cells (HCCECs), and whether this response is altered during hyperglycaemia in vitro, as haemodynamic signalling during penile erection ind...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06059.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To present the perioperative outcomes from the British Association of Urological Surgeons (BAUS) nephrectomy dataset for 2012, the first year of public reporting of individual surgeon outcomes in the UK. PATIENTS AND METHODS:All nephrectomies performed in the year 2012 and recorded in the database were analy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12770
更新日期:2015-01-01 00:00:00
abstract::There is ample evidence from many epidemiological studies that lower urinary tract symptoms (LUTS) and sexual dysfunction are strongly linked, independently of age and comorbidities such as hypertension, diabetes, dyslipidaemia and coronary heart disease. However, a causal link between both conditions is not yet estab...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2006.06102.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To develop a core outcome set (COS) applicable for effectiveness trials of all interventions for localised prostate cancer. Many treatments exist for localised prostate cancer, although it is unclear which offers the optimal therapeutic ratio; which is confounded by inconsistencies in the selection, definitio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13854
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To study the effects of diuretic stimulation with frusemide and mannitol on the renal resistive index (RI) of the undilated unobstructed porcine kidney. MATERIALS AND METHODS:Experiments were carried out on 14 pigs divided into two equal groups (A and B), under general anaesthesia. In all pigs both ureters w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01795.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08359.x
更新日期:2009-08-01 00:00:00
abstract:UNLABELLED:Study Type--Clinical (prospective trial) Level of Evidence 2b. What's known on the subject? and What does the study add? In clinical practice, we know that it is necessary to identify new biomarkers that can better detect prostate cancer (PC), at the same time as reducing the number of unnecessary biopsies. ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2012.11146.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To report a novel and straightforward technique of a secondary continent outlet for continent cutaneous urinary diversion (CCUD) reservoirs without the need for further bowel resection, reducing operating time and length of hospitalization. PATIENTS AND METHODS:From 2015 to 2017, six patients with unreconst...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13979
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the epidemiology of lower urinary tract symptoms (LUTS) among men and women, as there are significant unanswered questions about the prevalence and impact of LUTS in different populations. SUBJECTS AND METHODS:A population-based, cross-sectional survey was completed in Boxmeer (the Netherlands), ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04369.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To determine the effectiveness of cancer control afforded by radical prostatectomy (RP) in patients with clinical stage T3 prostate cancer. PATIENTS AND METHODS:We retrospectively reviewed data for patients treated by RP for clinical stage T3 prostate cancer between 1995 and 2005. The following case characte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08208.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To compare transurethral resection in saline (TURIS), Greenlight laser vapo-enucleation of the prostate (GL.PVEP), and holmium laser enucleation of the prostate (HoLEP), for controlling lower urinary tract symptoms secondary to large benign prostatic hyperplasia (BPH) and to assess non-inferiority of 3-year r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15161
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To report clinical outcomes of the Hemi-Ablative Prostate Brachytherapy (HAPpy) trial evaluating treatment-related toxicity and effectiveness of hemi-gland (HG) low-dose-rate (LDR) prostate brachytherapy as a focal approach to control unilateral localised prostate cancer. PATIENTS AND METHODS:Single institu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14948
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To describe the step-by-step learning curve of the holmium laser enucleation of the prostate (HoLEP) surgical technique. SUBJECTS/PATIENTS AND METHODS:A prospective, multicentre observational study was conducted, involving surgeons experienced in transurethral resection of the prostate and open prostatectom...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13124
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the degree of preoperative bladder trabeculation in neurogenic bladder (NB) patients is a marker of significant outlet resistance. If so, severe trabeculation may obviate the need for concomitant bladder outlet procedure (BOP) during augmentation cystoplasty (AC). PATIENTS AND METHODS:We ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07164.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12517
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary di...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14861
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of the learning curve on operative, postoperative, and pathological outcomes of the first 67 totally intracorporeal robot-assisted radical cystectomies (RARCs) with neobladders performed by two lead surgeons at Karolinska University Hospital. PATIENTS AND METHODS:Between December 2003 ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12347
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine if a decrease in oestrogen (E) levels increases activity in bladder afferent nerves, by investigating the effects of E loss on afferent nerve activity in ovariectomized (OVX) rats, and making comparisons with findings in ageing female rats. MATERIALS AND METHODS:Female Sprague-Dawley rats were d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09689.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility of using urodynamic variables to predict upper urinary tract dilatation (UUTD) in children with neurogenic bladder-sphincter dysfunction (NBSD). PATIENTS AND METHODS:The study included 200 children with NBSD, of whom 103 had UUTD and 97 did not; they were examined using routine...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06402.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant. PATIENTS AND METHODS:Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally det...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07562.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To identify a phenotype that could be informative and prognostic in patients with renal cell carcinoma (RCC) peripheral blood was evaluated for TH1, TH2, regulatory T cells (Tregs), natural killer (NK) and NKT cells and for cytokines/chemokines. PATIENTS AND METHODS:Peripheral blood from 77 patients with RCC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12068
更新日期:2013-09-01 00:00:00