Abstract:
OBJECTIVE:To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS:From 2002 to 2007, 1256 men had RP by one surgeon. Multivariable logistic regression and Cox proportional hazards models were used to examine the relationship of PNI with pathological tumour features and biochemical progression, respectively, after adjusting for prostate-specific antigen level, clinical stage and biopsy Gleason score. Additional Cox models were used to examine the relationship between nerve-sparing and biochemical progression among men with PNI. RESULTS:PNI was found in 188 (15%) patients, and was significantly associated with aggressive pathology and biochemical progression. On multivariate analysis, PNI was significantly associated with extraprostatic extension and seminal vesicle invasion (P < 0.001). Biochemical progression occurred in 10.5% of patients with PNI, vs 3.5% of those without PNI (unadjusted hazard ratio 3.12, 95% confidence interval 1.77-5.52, P < 0.001). However, PNI was not a significant independent predictor of biochemical progression on multivariate analysis. Finally, nerve-sparing did not adversely affect biochemical progression even among men with PNI. CONCLUSION:PNI is an independent risk factor for aggressive pathology features and a non-independent risk factor for biochemical progression after RP. However, bilateral nerve-sparing surgery did not compromise the oncological outcomes for patients with PNI on biopsy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Loeb S,Epstein JI,Humphreys EB,Walsh PCdoi
10.1111/j.1464-410X.2009.08845.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
1510-3issue
11eissn
1464-4096issn
1464-410Xpii
BJU8845journal_volume
105pub_type
杂志文章abstract:OBJECTIVE:To summarize the urological procedures recorded in Hospital Episodes Statistics (HES, 1998-99) and to examine the accuracy of coding and HES. MATERIALS AND METHODS:Data on the 10 commonest urological procedures from the Department of Health website (www.doh.gov.uk/hes) were extracted, summarized and presente...
journal_title:BJU international
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pub_type: 杂志文章,评审
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journal_title:BJU international
pub_type: 杂志文章,评审
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更新日期:2000-05-01 00:00:00
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更新日期:2012-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02375.x
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07941.x
更新日期:2009-01-01 00:00:00
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更新日期:2014-04-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00875.x
更新日期:2000-10-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (case series). Level of Evidence 4. What's known on the subject? And what does the study add? Adverse outcomes after radical prostatectomy are more often recorded in the elderly. In the USA, elderly patients undergoing radical prostatectomy are treated at institutions where suboptimal out...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10554.x
更新日期:2012-05-01 00:00:00
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doi:10.1111/j.1464-410X.2009.09046.x
更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.1111/j.1464-410X.2008.07698.x
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:2017-06-01 00:00:00
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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更新日期:2011-11-01 00:00:00
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更新日期:2020-08-03 00:00:00