Abstract:
UNLABELLED:Study Type--Therapy (case series). Level of Evidence 4. What's known on the subject? And what does the study add? Adverse outcomes after radical prostatectomy are more often recorded in the elderly. In the USA, elderly patients undergoing radical prostatectomy are treated at institutions where suboptimal outcomes are recorded. OBJECTIVE:• To assess the rate of adverse outcomes after open radical prostatectomy (ORP) in the elderly and to examine the effect of annual hospital caseload (AHC) and academic institutional status on adverse outcomes in these of patients. PATIENTS AND METHODS:• Within the Health Care Utilization Project Nationwide Inpatient Sample, we focused on ORPs performed between 1998 and 2007. Subsequently, we restricted to patients aged ≥75 years. • In both datasets, we examined transfusion rates, intra-operative and postoperative complication rates, and in-hospital mortality rates. • Stratification was performed according to AHC tertiles and academic status. • Multivariable logistic regression analyses were fitted. RESULTS:• Of 115,554 ORP patients, 2109 (1.8%) were aged ≥75 years. • In multivariable analyses performed in the entire cohort, elderly age increased homologous blood transfusion rates (P < 0.001), intra-operative (P= 0.001) and postoperative (P < 0.001) complication rates, and the mortality rate (P= 0.007). • Most elderly were treated at low or intermediate AHC (68.5%) and non-academic centres (56.2%). • Within the elderly cohort, intra-operative (2.9%) and postoperative (22.2%) complications tended to be highest at low AHC institutions compared to institutions of intermediate (2.7% and 17.4%) and high AHC (1.7% and 14.5%). Similarly, intra-operative (2.7% vs 2.1%) and postoperative complications (19.1% vs 13.9%) tended to be higher at non-academic than academic centres. • In multivariable analyses performed in the elderly subgroup, low AHC predicted higher intra-operative complications and higher homologous transfusions, whereas non-academic status predicted higher postoperative complications. CONCLUSIONS:• Adverse outcomes are more often recorded in the elderly. • Most elderly are treated at institutions where suboptimal outcomes are recorded.
journal_name
BJU Intjournal_title
BJU internationalauthors
Trinh QD,Schmitges J,Sun M,Shariat SF,Sukumar S,Tian Z,Bianchi M,Sammon J,Perrotte P,Rogers CG,Graefen M,Peabody JO,Menon M,Karakiewicz PIdoi
10.1111/j.1464-410X.2011.10554.xsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
1335-40issue
9eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
杂志文章abstract:OBJECTIVE:To evaluate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), from an analysis of pooled data from three phase III, multicentre, double-blind clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:After a 4-week washout/run-...
journal_title:BJU international
pub_type: 杂志文章,meta分析
doi:10.1111/j.1464-410X.2005.05454.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:• To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). • To evaluate their potential clinical implementation in a preoperative setti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10059.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively the accuracy of computer-aided three-dimensional (3D) volume-rendered computed tomography (CT) in determining the appropriate anatomical limits (tumour size, tumour location, multifocality and vascular supply) and as a potential tool in the preoperative simulation of nephron-sparing ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00898.x
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of urine cytology in the investigation of men with lower urinary tract symptoms (LUTS) in the absence of haematuria. PATIENTS AND METHODS:The study comprised 336 men attending a LUTS assessment clinic, who had neither macroscopic nor microscopic haematuria. One sample of urine was collec...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00151.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13904
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:• To study the association between specific clinical symptoms (e.g. low libido and erectile dysfunction) and testosterone levels and age in order to define symptom-specific testosterone thresholds. MATERIALS AND METHODS:• Serum samples for testosterone determination were obtained from 675 healthy men. • Part...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09986.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To compare the performance of two established androgen receptor splice variant 7 (AR-V7) mRNA detection systems, as paradoxical responses to next-generation androgen-deprivation therapy in AR-V7 mRNA-positive circulating tumour cells (CTC) of patients with castration-resistant prostate cancer (CRPC) could be...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14146
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). PATIENTS AND METHODS:We identified 131...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12769
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To analyse the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomised Study of Screening for Prostate Cancer (ERSPC) Risk Calculator, one of which incorporates prostate volume (ERSPC-RC) and the other of which incorporates prostate volume an...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.13437
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To examine the utility of cyanoacrylate tissue adhesive (Dermabond, Ethicon, Somerville, NJ, USA; an effective means of epithelial skin closure) under a diaper (i.e. constantly exposed to bodily fluids) in 25 children (not toilet-trained) undergoing inguinal surgery. PATIENTS AND METHODS:A retrospective revi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02142.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:To evaluate retrospectively the surgical, symptomatic and oncological outcomes of pelvic exenteration surgery (PES) in men with significant intrapelvic complications of locally advanced castration-sensitive (CSPC) and castration-resistant prostate cancer (CRPC). PATIENTS AND METHODS:A total of 103 patients ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15088
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine any bias by authors of different nationalities in their citation rate of selected urological journals in papers published in the British Journal of Urology and the Journal of Urology. METHODS:Using a simple computer program and text files of accepted reports in the BJU, or those available on CD-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00267.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To report our experience with laparoscopic robotic-assisted management of pelvi-ureteric junction obstruction (PUJO) in patients with horseshoe kidneys. PATIENTS AND METHODS:Between January 2002 and May 2003, two men and a woman with horseshoe kidneys (mean age 44.6 years) had laparoscopic dismembered pyelop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05967.x
更新日期:2006-03-01 00:00:00
abstract::To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPCa) in Hong Kong. A local expert consensus was organized jointly by the two main professional organizations representing prostate cancer specialists in Hong Kong. A total of 12 exper...
journal_title:BJU international
pub_type: 共识发展会议,杂志文章
doi:10.1111/bju.14091
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in bone mass and fracture risk in patients with prostate cancer on androgen-deprivation therapy (ADT) and with a basal T-score of >-2.0, who were treated with an oral bisphosphonate, as such patients treated with ADT are at increased risk of bone loss and bone fracture. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08622.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To identify biomarkers that predict the response to standard androgen deprivation therapy (ADT) of patients newly diagnosed with metastatic castration-sensitive prostate cancer (CSPC) in order to improve therapeutic decision-making, and to investigate whether the characterization of baseline circulating tumo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14642
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:To describe metoidioplasty, a technique for creating a neophallus from an enlarged clitoris in female transsexuals, without needing the complex, multi-staged surgical construction of a large phallus, as this reconstruction is one of the most difficult in female transsexuals. PATIENTS AND METHODS:From Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04524.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To report the medium-term results at our institution of repairing long bulbar urethral strictures with buccal mucosal grafts. PATIENTS AND METHODS:Between January 2003 and June 2007, a buccal mucosa graft repair was used in 34 patients with recurrent bulbar strictures >2 cm. The follow-up included uroflowme...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08848.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological asses...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09442.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect on cancer detection by varying the number of cores taken for prostate biopsy according to the size of the prostate. PATIENTS AND METHODS:A retrospective review of a prospectively registered prostate biopsy database identified 3040 consecutive patients undergoing prostate biopsy at a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10239.x
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:To prospectively evaluate the accuracy of transvesical contrast-enhanced ultrasound (CEUS) as an alternative method for the detection of anastomotic leakage after radical retropubic prostatectomy (RRP) in comparison with the current standard method of conventional retrograde cystography (CG). PATIENTS AND...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09497.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To study the effects of diuretic stimulation with frusemide and mannitol on the renal resistive index (RI) of the undilated unobstructed porcine kidney. MATERIALS AND METHODS:Experiments were carried out on 14 pigs divided into two equal groups (A and B), under general anaesthesia. In all pigs both ureters w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01795.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To validate a flexible cystoscopy simulator by determining if it could differentiate between expert and novice cystoscopists. SUBJECTS AND METHODS:Seventeen subjects (10 novices with no previous endoscopic experience and seven urologists who had all carried out > 1000 flexible cystoscopies each) were asked ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03090.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12333
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To describe the incidence, prevalence and management of lower urinary tract symptoms (LUTS), suggestive of benign prostatic hyperplasia, reported in UK general practice. PATIENTS AND METHODS:All clinical information relating to LUTS and its treatment was assessed for men aged > or = 45 years and registered o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05339.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To model renal function after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). To identify predictors of renal function decline after surgery, thereby allowing the identification of patients likely to be ineligible for cisplatin-based chemotherapy in the adjuvant setting. PATIEN...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12597
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To assess whether the optimal use of combined treatment with chemotherapy and appropriately timed surgical intervention by a specialized team might improve the outcome for patients with poor- and intermediate-prognosis (International Germ Cell Consensus Classification, IGCCC) nonseminomatous germ cell tumours...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04261.x
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To clarify the impact of endoscopic incision (EI) for ureterocele as an initial procedure, by performing a retrospective chart review, focusing on the prevalence of and risk factors for symptomatic urinary tract infection (UTI) after EI. MATERIALS AND METHODS:In the present study we included children with ur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13884
更新日期:2017-09-01 00:00:00