Abstract:
OBJECTIVE:To analyse the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomised Study of Screening for Prostate Cancer (ERSPC) Risk Calculator, one of which incorporates prostate volume (ERSPC-RC) and the other of which incorporates prostate volume and the prostate health index (PHI) in a referral population (ERSPC-PHI). PATIENTS AND METHODS:The risk of prostate cancer (PCa) and significant PCa (Gleason score ≥7) in 2001 patients from six tertiary referral centres was calculated according to the PCPT-RC and ERSPC-RC formulae. The calculators' predictions were analysed using the area under the receiver-operating characteristic curve (AUC), calibration plots, Hosmer-Lemeshow test for goodness of fit and decision-curve analysis. In a subset of 222 patients for whom the PHI score was available, each patient's risk was calculated as per the ERSPC-RC and ERSPC-PHI risk calculators. RESULTS:The ERSPC-RC outperformed the PCPT-RC in the prediction of PCa, with an AUC of 0.71 compared with 0.64, and also outperformed the PCPT-RC in the prediction of significant PCa (P<0.001), with an AUC of 0.74 compared with 0.69. The ERSPC-RC was found to have improved calibration in this cohort and was associated with a greater net benefit on decision-curve analysis for both PCa and significant PCa. The performance of the ERSPC-RC was further improved through the addition of the PHI score in a subset of 222 patients. The AUCs of the ERSPC-PHI were 0.76 and 0.78 for PCa and significant PCa prediction, respectively, in comparison with AUC values of 0.72 in the prediction of both PCa and significant PCa for the ERSPC-RC (P = 0.12 and P = 0.04, respectively). The ERSPC-PHI risk calculator was well calibrated in this cohort and had an increase in net benefit over that of the ERSPC-RC. CONCLUSIONS:The performance of the risk calculators in the present cohort shows that the ERSPC-RC is a superior tool in the prediction of PCa; however the performance of the ERSPC-RC in this population does not yet warrant its use in clinical practice. The incorporation of the PHI score into the ERSPC-PHI risk calculator allowed each patient's risk to be more accurately quantified. Individual patient risk calculation using the ERSPC-PHI risk calculator can be undertaken in order to allow a systematic approach to patient risk stratification and to aid in the diagnosis of PCa.
journal_name
BJU Intjournal_title
BJU internationalauthors
Foley RW,Maweni RM,Gorman L,Murphy K,Lundon DJ,Durkan G,Power R,O'Brien F,O'Malley KJ,Galvin DJ,Brendan Murphy T,William Watson Rdoi
10.1111/bju.13437subject
Has Abstractpub_date
2016-11-01 00:00:00pages
706-713issue
5eissn
1464-4096issn
1464-410Xjournal_volume
118pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To determine whether clinicians discuss bone-specific side-effects with patients on androgen-deprivation therapy (ADT) for prostate cancer, or prescribe lifestyle and pharmacological interventions for low bone mineral density (BMD), as decreased BMD is a common side-effect of ADT, leading to increased risk of...
journal_title:BJU international
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-12-01 00:00:00
abstract::Detrusor sphincter dyssynergia (DSD) is variant of neurogenic bladder dysfunction caused by suprasacral neurological abnormalities and may be associated with serious complications if unrecognised. This paper focuses on the clinical features as well as challenges and limitations in the diagnosis of DSD. ...
journal_title:BJU international
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:BJU international
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pub_type: 杂志文章,多中心研究
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04222.x
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journal_title:BJU international
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08033.x
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00