Abstract:
:To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPCa) in Hong Kong. A local expert consensus was organized jointly by the two main professional organizations representing prostate cancer specialists in Hong Kong. A total of 12 experts were included in the consensus panel. Six of the most crucial and relevant areas of debate regarding the management of mPCa were identified. With the use of a modified Delphi method, several panel meetings were held for the members to discuss their clinical experience and the published literature relevant to the areas of debate. At the final meeting, each drafted statement was voted on by every member based on its practicability of recommendation in the locality. After the panel voting, a total of 45 consensus statements regarding the management of mPCa were ultimately accepted and established. The consensus statements were primarily derived from the latest clinical evidence and major overseas guidelines, with the consideration of local clinical experience and practicability. These are considered applicable recommendations for Hong Kong physicians for the management of mPCa patients.
journal_name
BJU Intjournal_title
BJU internationalauthors
Poon DM,Chan CK,Chan TW,Cheung FY,Kwong PW,Lee EK,Leung AK,Leung SY,Ma WK,So HS,Tam PC,Ho LYdoi
10.1111/bju.14091subject
Has Abstractpub_date
2018-05-01 00:00:00pages
703-715issue
5eissn
1464-4096issn
1464-410Xjournal_volume
121pub_type
共识发展会议,杂志文章abstract::Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2008.07496.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To compare extracorporeal shockwave lithotripsy (ESWL) and ureteroscopy (URS) as first-line treatments for patients with distal ureteric stones. PATIENTS AND METHODS:In all, 273 patients with single, monolateral, radiopaque, distal ureteric stones of 0.5-1.5 cm were enrolled in a prospective randomized trial...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2010.09338.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To determine if the International Prostate Symptom Score (IPSS) before seed implantation, stratified into mild (0-7), moderate (8-19) and severe (>20) categories, predicts brachytherapy-related morbidity in terms of IPSS resolution, catheter dependency and the need for surgical intervention after brachytherap...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05887.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the oncological outcome and functional results of prostate-sparing cystectomy (PSC), proposed for treating bladder cancer, used since 1999 in our institution in an attempt to preserve male sexuality and to increase continence after cystectomy. PATIENTS AND METHODS:Between January 1999 and Decembe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05097.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To investigate whether visceral obesity is associated with certain histological subtypes of renal cell carcinoma (RCC) ina multicentre Chinese cohort. PATIENTS AND METHODS:A kidney tumour database was created using three tertiary centres in China; 487 patients were enrolled presenting with localised RCC and ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12592
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09695.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To determine if baseline characteristics, treatment efficacy, psychosocial outcomes or tolerability were associated with patient preference for sildenafil citrate (sildenafil) or tadalafil for treating erectile dysfunction (ED) in men naive to phosphodiesterase 5 inhibitor therapy. PATIENTS AND METHODS:In a...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2007.06916.x
更新日期:2007-07-01 00:00:00
abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08696.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To evaluate partial nephrectomy (PN) use in patients at higher risk for clinical progression, using a large national database of American patients. PATIENTS AND METHODS:We performed a retrospective review of patients with cN0/cM0 renal cell carcinoma from 2003 to 2011 using the National Cancer Data Base. Ou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13262
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To describe patient selection for sacral neuromodulation, also known as Interstim therapy, and the results of tined-lead implantation in the medium term. PATIENTS AND METHODS:In all, 49 patients, 39 with refractory overactive bladder symptoms and 10 with urinary retention, were implanted with the tined lead ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06508.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To define changes in the clinical pathway for open radical retropubic prostatectomy (RRP) and to determine their impact on patient care under the indirect influence of minimally invasive prostatectomy after implementing robotically assisted laparoscopic prostatectomy (RALP) at our institution and modifying th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To assess the durability of holmium laser enucleation of prostate in comparison to transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were enrolled in the present study between June 1997 and December 2000 and followed per protocol. All patients were urodynamically obstructed with a...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10359.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:To assess the cost, quality of life (QoL) and cost-effectiveness of a single-incision mini-sling (SIMS; Ajust(®) , C. R. Bard Inc., New Providence, NJ, USA) compared with a standard mid-urethral sling (SMUS; TVT-O™, Ethicon Inc., Somerville, NJ, USA) in the surgical management of female stress urinary incont...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.12388
更新日期:2013-12-01 00:00:00
abstract::The aim of revalidation (or maintenance of certification) is to reassure patients, the general public, employers and other healthcare professionals that an individual is fit to practice. It may lead to a reduction in near misses or adverse events. The process of revalidation entails a commitment to the provision of li...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10375.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of sustained-release (SR) bupropion to placebo in treating hypoactive sexual desire disorder (HSDD) in ovulating women. PATIENTS AND METHODS:After a 1-week, placebo lead-in phase, 232 treatment-seeking women with regular menstrual cycles were randomly assigned to bupropion SR 150 mg/d...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2010.09208.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00844.x
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To examine the effects of castration and continuous gonadotrophin releasing-hormone (GnRH) agonist and antagonist therapy on the expression of GnRH-receptors type I (GnRH-RI) in rat ventral prostate (VP) and pituitary tissue, and to compare the effects on prostate morphology. MATERIAL AND METHODS:Mature Spra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03054.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To investigate the immunohistochemical expression of topoisomerase II-alpha (TII-alpha, a nuclear enzyme, the expression of which increases rapidly at the end of the S to G2/M phase and declines when mitosis ends) in bladder urothelial neoplasms (transitional cell carcinoma), and its correlation with grade, s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04118.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10434.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To compare transurethral resection in saline (TURIS), Greenlight laser vapo-enucleation of the prostate (GL.PVEP), and holmium laser enucleation of the prostate (HoLEP), for controlling lower urinary tract symptoms secondary to large benign prostatic hyperplasia (BPH) and to assess non-inferiority of 3-year r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15161
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To examine the results of open partial nephrectomy (OPN) over a 15-year period in a large UK teaching hospital and to compare results with other series including minimally invasive techniques, as nephron-sparing techniques are still under-utilized in the surgical treatment of renal carcinoma. A standardized ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07829.x
更新日期:2008-11-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Extracorporeal shockwave lithotripsy is effective for the treatment of paediatric renal stones with favourable short-term safety. Extracorporeal shockwave lithotripsy for treatment of paediatric renal stones is also safe for the kidney and the child ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11420.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To assess the potential of p21 as a gene therapy treatment for prostate cancer, by introducing p21 into both androgen-dependent (AD) and -independent (AI) human prostate cancer cell lines via a recombinant adenoviral vector, Ad5CMV-p21, carrying human p21 cDNA. MATERIALS AND METHODS:The LNCaP, DU145 and PC-3...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04318.x
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To determine whether aneusomy for chromosomes 7, 9 and 17 (reported to predict recurrence in up to 65% of patients with superficial transitional cell bladder cancer and thus providing the opportunity for early and effective treatment) reflects specific genetic events on these chromosomes or merely wider unspe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00268.x
更新日期:1999-11-01 00:00:00
abstract::For the delivery of good-quality external beam radiotherapy (EBRT) in localized prostate cancer, under-dosage to the peripheral zone (tumour) is one likely cause of poor results. The quality is improved by daily verification of the position of the prostate, and the use of magnetic resonance imaging (MRI) in delineatio...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07346.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To analyze pathological and short-term oncological outcomes in men undergoing open and minimally-invasive radical prostatectomy (MIRP) for high-risk prostate cancer (HRPC; prostate-specific antigen level [PSA] >20 ng/mL, ≥ cT2c, Gleason score 8-10) in a contemporaneous series. PATIENTS AND METHODS:In total,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11757.x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11137.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of inside-out transobturator tape (tension-free vaginal tape-obturator, TVT-O) for the treatment of stress urinary incontinence (SUI). PATIENTS AND METHODS:Between August 2004 and August 2006, 87 consecutive patients with SUI who underwent TVT-O were enrolle...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14555
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02033.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To investigate the frequency and spectrum of lipophilic Malassezia yeasts within the area of the glans penis and preputial space in healthy men, most of whom were uncircumcised. SUBJECTS AND METHODS:As the glans penis and the prepuce are abundant in sebaceous glands, 130 clinically healthy men were examined ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02375.x
更新日期:2001-10-01 00:00:00