Anaemia in men receiving combined finasteride and flutamide therapy for advanced prostate cancer.

Abstract:

OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of advanced disease, were treated with combined finasteride (5 mg/day) and flutamide (750 mg/day) for at least 6 months. Complete blood counts were performed before initiation and after 6 months of therapy. RESULTS:After 6 months of finasteride and flutamide therapy both haemoglobin levels and haematocrit decreased in all men, with a mean (sd, range) decrease of 16 (10, 3-42) g/L and 4.6 (2.7, 0.8-9.9)%, respectively. CONCLUSION:Combined finasteride and flutamide therapy significantly lowers haemoglobin and haematocrit levels in men with advanced prostate cancer, and further study of this effect is warranted.

journal_name

BJU Int

journal_title

BJU international

authors

Ornstein DK,Beiser JA,Andriole GL

doi

10.1046/j.1464-410x.1999.00844.x

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

43-6

issue

1

eissn

1464-4096

issn

1464-410X

journal_volume

83

pub_type

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