Abstract:
OBJECTIVE:To retrospectively review the long-term activity, efficacy and toxicity of the combination of paclitaxel, cisplatin and gemcitabine (TPG) as third- or further-line chemotherapy in patients with germ-cell tumours (GCTs) who are not cured after at least two courses of standard-dose chemotherapy, high-dose chemotherapy or both. PATIENTS AND METHODS:We evaluated 22 consecutive men treated between April 1999 and December 2000. Half of them were classified as absolutely refractory to cisplatin and a further two as refractory. The median (range) number of previous courses of chemotherapy was 8 (5-11). Treatment consisted of paclitaxel 80 mg/m(2), cisplatin 50 mg/m(2) and gemcitabine 800 mg/m(2) on days 1 and 8, every 3 weeks for four courses, followed by surgery of actual residual resectable masses. RESULTS:The follow-up was updated at August 2007. There were no deaths from toxicity and only one patient needed suspension of therapy for toxicity. There was both grade 3-4 thrombocytopenia and neutropenia in 15 patients (68%), and anaemia in nine (41%). There were partial remissions in eight (36%) patients. Six (27%) patients were rendered disease-free with surgical removal of a residual mass after chemotherapy (two still containing viable cancer). Four (18%) patients are long-term survivors at more than 80, 81, 94 and 99 months. The median (range) overall survival of the whole series was 13.5 (1->99) months. CONCLUSION:This combination had a toxicity profile that was acceptable and comparable with other third-line regimens. There were eight (36%) major responses. After a 6-year minimum follow-up, four (18%) patients were long-term disease-free survivors.
journal_name
BJU Intjournal_title
BJU internationalauthors
Nicolai N,Necchi A,Gianni L,Piva L,Biasoni D,Torelli T,Stagni S,Milani A,Pizzocaro G,Salvioni Rdoi
10.1111/j.1464-410X.2009.08453.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
340-6issue
3eissn
1464-4096issn
1464-410Xpii
BJU8453journal_volume
104pub_type
杂志文章abstract:OBJECTIVE:To assess the factors that influence the onset of androgen independence (AI, which heralds a dismal outcome) in patients with metastatic prostate carcinoma. PATIENTS AND METHODS:The records of 361 consecutive patients with prostate carcinoma diagnosed and treated in the authors' institution from 1 January 19...
journal_title:BJU international
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abstract:OBJECTIVE:To evaluate a novel urine-collection device (UCD) that automatically collects a midstream urine (MSU) sample, and compare contamination rates to those of the conventional MSU sampling method, as the contamination of urine samples for microbiological analysis in women leads to diagnostic ambiguity and unnecess...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2005.05631.x
更新日期:2005-08-01 00:00:00
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abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.06777.x
更新日期:2007-05-01 00:00:00
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doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11187.x
更新日期:2012-10-01 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06211.x
更新日期:2006-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06430.x
更新日期:2006-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2009.08196.x
更新日期:2009-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-12-01 00:00:00
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journal_title:BJU international
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更新日期:2012-12-01 00:00:00
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journal_title:BJU international
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更新日期:2003-08-01 00:00:00
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更新日期:2000-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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更新日期:2010-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07829.x
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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