Abstract：
OBJECTIVE:To assess the factors that influence the onset of androgen independence (AI, which heralds a dismal outcome) in patients with metastatic prostate carcinoma. PATIENTS AND METHODS:The records of 361 consecutive patients with prostate carcinoma diagnosed and treated in the authors' institution from 1 January 1996 to 31 December 1999 were reviewed retrospectively; 92 with metastatic prostate carcinoma were assessed (median age 71.0 years, range 42-93). Patients were included if they developed metastatic disease from prostate cancer at the time of diagnosis. The nadir for prostate specific antigen (PSA) level was defined as the date of the lowest PSA level after hormonal therapy, and AI was defined as the date of the third consecutive PSA increase above the nadir value by any threshold. RESULTS:The median Gleason sum was 8 and the modal Gleason score 4 + 5. The median (range) pretreatment PSA level was 274.0 (1.3-2179) ng/mL. Of the 92 men, 57 (62%) attained a nadir PSA, including 23 with a nadir of < 2 ng/mL; 32 (35%) progressed to AI within 2 years and 27% reached a nadir PSA but did not develop AI. The mean (sd) time from diagnosis to the nadir PSA was 13.7 (11.8) months, while the mean time from diagnosis to progression to AI was 30.3 (15.6) months. Univariate analysis showed that a nadir PSA level after treatment of >/= 1 ng/mL (P = 0.0128) was an early predictor of progression to AI; a nadir PSA level of >/= 2 ng/mL (P = 0.0216) was a predictor of poor overall survival. CONCLUSION:Failure to attain a nadir PSA of < 1 ng/mL after treatment predicts progression to AI and a nadir PSA of > 2 ng/mL predicts poorer overall survival. The development of skeletal events predicts the onset of AI but occurs late in the disease and is unsuitable as an early prognostic marker.
journal_name
BJU Intjournal_title
BJU internationalauthors
Sim HG,Lau WK,Cheng CWdoi
10.1111/j.1464-410X.2004.04863.xkeywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1221-4issue
9eissn
1464-4096issn
1464-410Xpii
BJU4863journal_volume
93pub_type
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pub_type： 杂志文章,多中心研究
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doi：10.1111/j.1464-410X.2012.11313.x
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abstract：UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...
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pub_type： 杂志文章
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journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2003.04020.x
更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.07606.x
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1464-410X.2009.08467.x
更新日期：2009-09-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1046/j.1464-410x.2001.02179.x
更新日期：2001-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1464-410X.2004.05034.x
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pub_type： 杂志文章
doi：10.1111/j.1464-410X.2004.04815.x
更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1464-410X.2009.08196.x
更新日期：2009-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1464-410x.2000.00597.x
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pub_type： 杂志文章,随机对照试验
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doi：10.1111/j.1464-410X.2006.06522.x
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doi：10.1111/j.1464-410X.2005.05566.x
更新日期：2005-07-01 00:00:00
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更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2002-02-01 00:00:00
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更新日期：1999-09-01 00:00:00
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更新日期：2007-01-01 00:00:00
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更新日期：2019-02-01 00:00:00
