Abstract:
:Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewed previous publications to provide guidelines in terms of criteria, limitations and clinical value of available tools for predicting patient outcome after RC. Our findings suggest that while individual surgical, patient and pathological features provide useful estimates of survival outcome, the inherent heterogeneity of tumour biology and patient characteristics leads to significant variation in outcome. By incorporating all relevant continuous predictive factors for individual patients, integrative predictive models, such as nomograms or artificial neural networks, provide more accurate predictions and generally surpass clinical experts at predicting outcomes. Nonetheless, there is a clear need for the development and validation of molecular biomarkers and their incorporation into multivariable predictive tools. Significant progress has been made in identifying important molecular markers of disease and the development of multifactorial tools for predicting the outcome after RC.
journal_name
BJU Intjournal_title
BJU internationalauthors
Margulis V,Lotan Y,Montorsi F,Shariat SFdoi
10.1111/j.1464-410X.2008.07594.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
15-22issue
1eissn
1464-4096issn
1464-410Xpii
BJU7594journal_volume
102pub_type
杂志文章,评审abstract:OBJECTIVE:To evaluate the association of patient age with pathological and long-term oncological outcomes after radical cystectomy (RC) for bladder carcinoma, as this disease, like many others, increases in incidence with age. PATIENTS AND METHODS:We retrospectively reviewed 241 consecutive patients with invasive blad...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08033.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility and efficacy of suicide-gene therapy using adenovirus (Ad)-mediated herpes simplex virus thymidine kinase (HSV-TK) and the prodrug acyclovir, and to evaluate changes in the biological phenotype for tumour cell proliferative activity after suicide-gene therapy in animal models of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00516.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To report our experience with the use of 95% ethanol as sclerotherapy for symptomatic simple renal cysts. PATIENTS AND METHODS:Sixty patients with 64 symptomatic simple renal cysts were treated by ultrasonography (US)-guided percutaneous aspiration and injection of 95% ethanol (31 men and 29 women, mean age ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05851.x
更新日期:2005-12-01 00:00:00
abstract::What's known on the subject? and What does the study add? The suppressor effect of probiotics on superficial bladder cancer is an observed phenomenon but the specific mechanism is poorly understood. The evidence strongly suggests natural killer (NK) cells are the anti-tumour effector cells involved and NK cell activit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10749.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To identify a phenotype that could be informative and prognostic in patients with renal cell carcinoma (RCC) peripheral blood was evaluated for TH1, TH2, regulatory T cells (Tregs), natural killer (NK) and NKT cells and for cytokines/chemokines. PATIENTS AND METHODS:Peripheral blood from 77 patients with RCC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12068
更新日期:2013-09-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the diffusion of nephron-sparing modalities (NSM) for the treatment of renal neoplasms in the USA over the last decade and to identify the factors associated with renal procedure selection. PATIENTS AND METHODS:The Nationwide Inpatient Sample was utlized to identify patients undergoing cryo/radio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11497.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To determine the partner's influence on the patient's choice of treatment for early prostate cancer, and whether partner characteristics and biases predict the preference. PATIENTS, SUBJECTS AND METHODS:Questionnaires for partners to complete retrospectively were sent to consecutive patients recruited in a s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04355.x
更新日期:2003-09-01 00:00:00
abstract:STUDY TYPE:Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data. PATIENTS AND METHODS:This retrospective study included 34 patients treated between October 1997 and October 2007 (...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08813.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To determine the 5-year oncological outcomes of endoscopic extraperitoneal radical prostatectomy (EERPE) from a medium-volume centre, thereby providing much needed data on outcomes from the UK. PATIENTS AND METHODS:From January 2006 to January 2012, 575 patients underwent EERPE for localized prostate cancer,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12260
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To interrogate enriched prostate cancer cells and autologous non-malignant prostate epithelial cells from men with localized prostate cancer, in order to identify early oncogenic pathways. PATIENTS AND METHODS:We collected malignant and matched non-malignant prostatectomy samples from men with adenocarcinoma...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14695
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse of testicular germ cell tumours (TGCTs), in the follow-up of TGCTs for detecting tumour relapse, as it has role as a prognostic factor but its role in follow-up is less certain. PATIEN...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06905.x
更新日期:2007-07-01 00:00:00
abstract::Jim Peters, a country boy who excelled academically and in the sporting arena was a Victorian urological pioneer. His passion for teaching and belief in the development of Australasian urology resulted in the establishment of two of Melbourne's earliest Urology Units (which are now major academic University department...
journal_title:BJU international
pub_type: 传,历史文章,杂志文章
doi:10.1111/bju.12377
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To identify and describe changes to the motor component of the motor/sensory system, which contributes to sensation during the filling phase of the micturition cycle, as a result of surgically induced bladder pathology, i.e. damage to the bladder neck and outlet obstruction. MATERIALS AND METHODS:Adult male ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07129.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To assess psychometrically a new questionnaire for measuring the psychosocial morbidity in patients with prostate cancer and in their partners, and to compare the morbidity of patients and their partners. PATIENTS AND METHODS:A sequential sample of patients with any stage of prostate cancer and attending gen...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00914.x
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk. PATIENTS AND METHODS:We conducted a retrospective analysis of 450 men treated with prostatectomy at a tertiar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10422.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). PATIENTS AND METHODS:We identified 131...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12769
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00075.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To determine the mechanism that underlies the effect of shock wave (SW) rate on the performance of clinical lithotripters. MATERIALS AND METHODS:The effect of firing rate on the pressure characteristics of SWs was assessed using a fibre-optic probe hydrophone (FOPH 500, RP Acoustics, Leutenbach, Germany). Sh...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07896.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To assess the factors that influence the onset of androgen independence (AI, which heralds a dismal outcome) in patients with metastatic prostate carcinoma. PATIENTS AND METHODS:The records of 361 consecutive patients with prostate carcinoma diagnosed and treated in the authors' institution from 1 January 19...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04863.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To determine the outcome 10 years after an individual course of pelvic floor muscle (PFM) exercises for genuine stress incontinence. PATIENTS AND METHODS:Postal questionnaires were sent to 52 women who had undergone PFM training 10 years earlier, and their medical files were reviewed. The main outcome measur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00506.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical prostatectomy are common, although their impact on the risk of disease recurrence is unknown. We examined the impact of PSMs on the risk of 'significant' biochemical recurrence stratified by their risk of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10868.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12333
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To determine whether health-insurance status might result in more localized stage at presentation, more favourable stage at surgery and in a lower rate of biochemical recurrence (BCR), in patients diagnosed with prostate cancer and treated with radical prostatectomy (RP), as despite uninhibited access to heal...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.06771.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To determine the effect of a deep and narrow pelvis on apical positive surgical margins (PSM) at radical prostatectomy (RP), controlling for other clinical and pathological variables and surgical approach, i.e. open retropubic (RRP) vs laparoscopic (LRP), as apical dissection is expected to be more challengin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09184.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate a group of young women undergoing complex vaginoplasty, which may be defined as where there has already been previous complex pelvic surgery and the patient is unsuitable for conservative treatment or minor surgical revision. PATIENTS AND METHODS:All patients who had undergone a complex vaginopla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05522.x
更新日期:2005-06-01 00:00:00
abstract::What is known on the subject? and What does the study add? Substantial experience of the outcomes has been gathered regarding the acute and sub-acute experience with various types of corrective procedures for POP. These include long-term POP correction as well as more recent recognition of improvement in functional di...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10123.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence of lower urinary tract symptoms (LUTS) and urinary incontinence (UI) in Canada, using a cross-Canada telephone survey, as there is a wide discrepancy in the reported prevalence of these conditions. SUBJECTS AND METHODS:A random survey with a standardized questionnaire was conducte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07198.x
更新日期:2008-01-01 00:00:00
abstract::Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it represents a part of the urinary tract exposed to a consid...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2010.09835.x
更新日期:2011-07-01 00:00:00