Abstract:
OBJECTIVE:To identify and describe changes to the motor component of the motor/sensory system, which contributes to sensation during the filling phase of the micturition cycle, as a result of surgically induced bladder pathology, i.e. damage to the bladder neck and outlet obstruction. MATERIALS AND METHODS:Adult male guinea pigs (294-454 g) were assigned initially into three groups: (i) normal guinea pigs with no surgical intervention (control, seven); (ii) guinea pigs which, with full surgical anaesthesia, had a silver ring implanted around the bladder neck (obstructed, 13); and (iii) guinea pigs operated to expose the bladder neck but with no implantation of a ring (sham, six). At 2-4 weeks after surgery the bladders were isolated, weighed and the pressure recordings used to identify autonomous activity. RESULTS:The bladder weights in all operated groups, including the sham, were greater than controls. Bladder weights in the obstructed guinea pigs varied considerably, reflecting the degree of pathological change. Consequently, bladders from this group were divided into those with high (OBH) and those with low bladder weight (OBL). The mean (sd) amplitudes of the autonomous contractions were 1.1 (0.1), 10.8 (1.8), 11.4 (2.5) and 17.1 (4.0) cmH(2)O in control, sham, OBL and OBH bladders, respectively, indicating a progressive alteration in function with the pathology. The changes in the sham group suggested that the pathological changes were not the result of obstruction but damage to the bladder neck, the implantation of the silver rings exacerbating the damage. There were episodes of rapid phasic activity (bursts) in 10 of 13 of the ring-implanted bladders, and in two of six in the sham group, but never in controls. Neither the autonomous activity nor the bursts were affected by tetrodotoxin (1 microm) or atropine (3 microm) but they were abolished by noradrenaline (3 microm). In control bladders, adding the muscarinic agonist arecaidine produced a transient acceleration of phasic activity and increased the amplitude of the contractions. There was a similar acceleration of activity in all the operated groups but the concentrations needed to achieve an increase in frequency were significantly lower, the relative sensitivity to arecaidine being OBH >/= OBL > sham > control. CONCLUSION:The mechanism involved in controlling the frequency of the motor component of the motor/sensory system, the 'pacemaker', appears to become progressively 'supersensitive' to cholinergic stimulation with the development of pathology. These observations are discussed in relation to the motor/sensory system and the origins of sensation in the bladder. The argument is proposed that damage to the bladder neck, not obstruction per se, results in altered nonmicturition activity which contributes to increased afferent output. In turn this contributes to the increased sensations of urge associated with bladder dysfunction. The cholinergic regulation of this altered 'pacemaker' might be the target for one of the therapeutic actions of anticholinergic drugs.
journal_name
BJU Intjournal_title
BJU internationalauthors
de Jongh R,van Koeveringe GA,van Kerrebroeck PE,Markerink-van Ittersum M,de Vente J,Gillespie JIdoi
10.1111/j.1464-410X.2007.07129.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
919-29issue
4eissn
1464-4096issn
1464-410Xpii
BJU7129journal_volume
100pub_type
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journal_title:BJU international
pub_type: 杂志文章,评审
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09144.x
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abstract:OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00019.x
更新日期:1999-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Elderly patients have more years to compound comorbidities and it has previously been shown that comorbidity is an important predictor of overall survival in patients with bladder cancer, including those treated with radical cystectomy (RC). Other stu...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11180.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To highlight the existence of Schistosoma haematobium in certain ethnic minority groups in Britain and in English citizens who have recently visited Africa and the Middle East, so that general practitioners and paediatric nephrologists/urologists are aware of its occurrence and consider it among the different...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00477.x
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To explore the meaning that men attach to their experiences of having lower urinary tract symptoms (LUTS) and to understand 'bother' in the context of those meanings. PATIENTS AND METHODS:Sixteen men with symptoms suggestive of LUTS and/or an enlarged prostate were recruited from the outpatient urology clini...
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doi:10.1111/j.1464-410X.2005.05720.x
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abstract:UNLABELLED:Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Selective destruction of targeted prostate tissue is now technically feasible. Much has been theorized but little is known about the proper patient selection or treatment outcomes to determine if this...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10578.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To establish the predictive accuracy of the Kattan preoperative nomogram by comparing predictions at 5 years with actual progression in patients who had a radical prostatectomy (RP). MATERIALS AND METHODS:We reviewed the data for 928 patients treated by RP as a first-line treatment for localized prostate can...
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pub_type: 杂志文章,多中心研究
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更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14567
更新日期:2019-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08001.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To analyse the technical details and the long-term results of laparoscopic ureterolithotomy. PATIENTS AND METHODS:Laparoscopic ureterolithotomy was undertaken in 101 patients between 1991 and 2001; in only one patient with retroperitoneal fibrous adhesions was the procedure transperitoneal, being retroperito...
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pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01562.x
更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2011-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2003.04715.x
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06194.x
更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06508.x
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06726.x
更新日期:2007-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00467.x
更新日期:2000-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08984.x
更新日期:2010-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08163.x
更新日期:2009-04-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00778.x
更新日期:2000-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.13437
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04914.x
更新日期:2004-07-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of inside-out transobturator tape (tension-free vaginal tape-obturator, TVT-O) for the treatment of stress urinary incontinence (SUI). PATIENTS AND METHODS:Between August 2004 and August 2006, 87 consecutive patients with SUI who underwent TVT-O were enrolle...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14555
更新日期:2019-05-01 00:00:00