Tumour contact surface area as a predictor of postoperative complications and renal function in patients undergoing partial nephrectomy for renal tumours.


OBJECTIVES:To evaluate the ability of original tumour contact surface area (CSA) to predict postoperative complications and renal function impairment in a series of patients who underwent elective partial nephrectomy (PN) for renal masses. MATERIALS AND METHODS:We analysed the clinical records of 531 consecutive patients who underwent elective PN because of a suspicion of kidney cancer at five academic, high-volume centres between January 2014 and December 2016. Each participating centre evaluated prospectively the radiological images to evaluate the CSA and to assign a PADUA score. Several expert surgeons performed the surgical procedures in each participating centre. Binary logistic regression was used to perform both univariable and multivariable analyses to identify predictors of postoperative complications. Linear regression analysis was used to identify independent predictors of absolute change in estimated glomerular filtration rate (eGFR; ACE). RESULTS:The median (interquartile range) CSA value was 14.2 (7.4-25.1) cm2 . A total of 349 tumours (65.7%) had a CSA ≤ 20 cm2 and the remaining 182 (34.3%) had a CSA > 20 cm2 . PNs were performed using an open approach in 237 (44.6%) cases, a pure laparoscopic approach in 152 cases (28.6%), and a robot-assisted approach in the remaining 142 cases (26.7%). Multivariable analyses found that only age (odds ratio [OR] 1.037, 95% confidence interval [CI] 1.018-1.057) and PADUA score (OR 1.289, 95%CI 1.132-1.469) were independent predictors of postoperative complications. Tumour CSA (OR 1.020, 95%CI 1.010-1.030) was found to be an independent predictor of postoperative complications only when PADUA score was removed from the model. Age (from -0.639 to -0.306; P < 0.001); body mass index (from 0.267 to 1.076; P = 0.001), age-adjusted Charlson score (from -3.193 to -0.259; P = 0.02), preoperative eGFR value (from -0.939 to -0.862; P < 0.001) and tumour CSA (from -0.260 to -0.048; P = 0.005) were found to be independent predictors of ACE. CONCLUSIONS:Tumour CSA is an independent predictor of postoperative renal function. Conversely, at multivariable analysis, PADUA score outperformed tumour CSA to predict postoperative complications after PN. The complexity of The Leslie et al. formula for calculating tumour CSA is a potential limitation with regard to its diffusion and application in clinical practice.




BJU international


Ficarra V,Crestani A,Bertolo R,Antonelli A,Longo N,Minervini A,Novara G,Simeone C,Carini M,Mirone V,Porpiglia F,Collaborators.




Has Abstract


2019-04-01 00:00:00












  • Phase II study of cytarabine in men with docetaxel-refractory, castration-resistant prostate cancer with evaluation of TMPRSS2-ERG and SPINK1 as serum biomarkers.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? To date, there has been limited impetus to examine the use of cytarabine in prostate cancer. We presented preliminary laboratory data to suggest its utility in the castration refractory prostate cancer (CRPC) population which, combined with a previous...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Dhani NC,Emmenegger U,Adams L,Jongstra J,Tannock IF,Sridhar SS,Knox JJ,Day JR,Groskopf J,Joshua AM

    更新日期:2012-09-01 00:00:00

  • Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.

    abstract:OBJECTIVE:To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO). PATIENTS AND METHODS:In all, 255 children and adolescents (aged 1-18 years) with NDO ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Madersbacher H,Mürtz G,Alloussi S,Domurath B,Henne T,Körner I,Niedeggen A,Nounla J,Pannek J,Schulte-Baukloh H,Schultz-Lampel D,Bock P,Strugala G

    更新日期:2009-03-01 00:00:00

  • The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.

    abstract:OBJECTIVES:To comprehensively investigate the role of the N6 -methyladenosine (m6 A) erasers ALKBH5 and FTO in clear cell renal cell carcinoma (ccRCC), other RCC subtypes, and oncocytoma with respect to prognostic value and biomarker potential. PATIENTS AND METHODS:The collection of tissue samples was performed within...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Strick A,von Hagen F,Gundert L,Klümper N,Tolkach Y,Schmidt D,Kristiansen G,Toma M,Ritter M,Ellinger J

    更新日期:2020-04-01 00:00:00

  • Diabetes predicts metastasis after radical prostatectomy in obese men: results from the SEARCH database.

    abstract:OBJECTIVE:To examine the association between diabetes and metastasis risk after radical prostatectomy (RP) and to determine if race or obesity modifies this relationship. PATIENTS AND METHODS:Patients comprised 2058 US veterans with prostate cancer (PCa) enrolled in the Shared Equal-Access Regional Cancer Hospital (SE...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Wu C,Aronson WJ,Terris MK,Presti JC Jr,Kane CJ,Amling CL,Freedland SJ

    更新日期:2013-06-01 00:00:00

  • Does the presence of muscularis propria on transurethral resection of bladder tumour specimens affect the rate of upstaging in cT1 bladder cancer?

    abstract:UNLABELLED:OBJECTIVE • To determine how the presence of MP on T1 biopsy specimens affects the outcome of patients undergoing RC as compared to when no MP is identified in the TURBT specimen. PATIENTS AND METHODS:• Patients were retrospectively identified from the Columbia University Urologic Oncology Database. • From ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Badalato G,Patel T,Hruby G,McKiernan J

    更新日期:2011-10-01 00:00:00

  • Urinary tract abnormalities in boys with recurrent urinary tract infections after hypospadias repair.

    abstract:OBJECTIVE:To examine the development of recurrent urinary tract infections (UTIs) in boys who have undergone hypospadias repair. MATERIALS AND METHODS:We retrospectively reviewed the records of all boys who had recurrent UTIs after primary or redo tubularized incised plate (TIP) or transverse island flap (TVIF) repair...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Wehbi E,Patel P,Kanaroglou N,Tam S,Weber B,Lorenzo A,Pippi Salle JL,Bagli D,Koyle M,Farhat WA

    更新日期:2014-02-01 00:00:00

  • A case-control study of risk factors in men with chronic pelvic pain syndrome.

    abstract:OBJECTIVE:To compare the demographic, behavioural, clinical and medical history characteristics of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and asymptomatic controls, to identify characteristics that might be associated with this syndrome. PATIENTS AND METHODS:Self-administered epidemiologic...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Pontari MA,McNaughton-Collins M,O'leary MP,Calhoun EA,Jang T,Kusek JW,Landis JR,Knauss J,Litwin MS,CPCRN Study Group.

    更新日期:2005-09-01 00:00:00

  • A 10-year follow-up after Kegel pelvic floor muscle exercises for genuine stress incontinence.

    abstract:OBJECTIVE:To determine the outcome 10 years after an individual course of pelvic floor muscle (PFM) exercises for genuine stress incontinence. PATIENTS AND METHODS:Postal questionnaires were sent to 52 women who had undergone PFM training 10 years earlier, and their medical files were reviewed. The main outcome measur...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Cammu H,Van Nylen M,Amy JJ

    更新日期:2000-04-01 00:00:00

  • Comparison of transfusion requirements between open and robotic-assisted laparoscopic radical prostatectomy.

    abstract:OBJECTIVE:To determine whether robotic-assisted laparoscopic radical prostatectomy (RALP) is associated with a lower transfusion rate than radical retropubic prostatectomy (RRP). PATIENTS AND METHODS:In this cohort study, we evaluated 1244 consecutive patients who underwent RALP (830) or RRP (414) between June 2003 an...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kordan Y,Barocas DA,Altamar HO,Clark PE,Chang SS,Davis R,Herrell SD,Baumgartner R,Mishra V,Chan RC,Smith JA Jr,Cookson MS

    更新日期:2010-10-01 00:00:00

  • Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro.

    abstract:OBJECTIVE:To evaluate the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) over-expression on the invasion-associated proteins in human prostate cancer cells, as HIF-1alpha is a transcriptional factor that could activate genes involved in the response to hypoxia, but might also enhance the invasive potency of pro...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Luo Y,He DL,Ning L,Shen SL,Li L,Li X,Zhau HE,Chung LW

    更新日期:2006-12-01 00:00:00

  • Direct comparison of radiology and nuclear medicine cystograms in young infants with vesico-ureteric reflux.

    abstract:OBJECTIVE:To determine the sensitivity of the direct radionuclide cystogram (DRC) in detecting vesico-ureteric reflux compared with the micturating cysto-urethrogram (MCU) in the same initial setting, in infants younger than one year. PATIENTS AND METHODS:The results from the dual cystograms of 62 refluxing infants < ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: McLaren CJ,Simpson ET

    更新日期:2001-01-01 00:00:00

  • Effects of ageing and streptozotocin-induced diabetes on connexin43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder.

    abstract:OBJECTIVE:To investigate whether ageing and diabetes alter the expression of the gap junction protein connexin43 (Cx43) and of particular purinoceptor (P2R) subtypes in the corpus cavernosum and urinary bladder, and determine whether changes in expression of these proteins correlate with development of erectile and bla...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Suadicani SO,Urban-Maldonado M,Tar MT,Melman A,Spray DC

    更新日期:2009-06-01 00:00:00

  • Second-generation of temporary implantable nitinol device for the relief of lower urinary tract symptoms due to benign prostatic hyperplasia: results of a prospective, multicentre study at 1 year of follow-up.

    abstract:OBJECTIVES:To report the clinical experience with a second-generation of temporary implantable nitinol device (iTIND; Medi-Tate Ltd, Or-Akiva, Israel) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) after 1 year of follow-up. PATIENTS AND METHODS:In all, 81 patients w...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Porpiglia F,Fiori C,Amparore D,Kadner G,Manit A,Valerio M,Nicolaas L,Ho BSH,Alonso S,Schulman C,Barber N

    更新日期:2019-06-01 00:00:00

  • Ureteric embolization with stainless-steel coils for managing refractory lower urinary tract fistula: a 12-year experience.

    abstract:OBJECTIVE:To report our 12-year experience with radiological treatment (ureteric embolization) for refractory urinary fistula, as malignancy, radiation therapy, and/or chronic inflammation increase the risk of lower urinary tract fistula after surgical urinary diversion, which can lead to significant morbidity, and for...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Shindel AW,Zhu H,Hovsepian DM,Brandes SB

    更新日期:2007-02-01 00:00:00

  • Predictive factors for nocturia in elderly men: a cross-sectional study in 21 general practices.

    abstract:OBJECTIVE:To measure the prevalence of nocturia in general practice and to determine which factors are associated with nocturia. SUBJECTS AND METHODS:Data were collected from 3048 elderly men, who completed a questionnaire that was sent to every man aged 55-75 years in 21 general practices in Maastricht (the Netherlan...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Gourova LW,van de Beek C,Spigt MG,Nieman FH,van Kerrebroeck PE

    更新日期:2006-03-01 00:00:00

  • Radical prostatectomy in Britain and Ireland at the millennium.

    abstract:OBJECTIVE:To report a national questionnaire survey of all consultant urologists, providing a 'snapshot' of attitudes, current practice and referral patterns for radical prostatectomy (RP) in Britain and Ireland at the millennium. METHODS:During 1999/2000 a simple questionnaire about RP was sent to the 487 urologists ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ravichandran S,Dasgupta P,Booth CM

    更新日期:2002-09-01 00:00:00

  • Visceral fat accumulation is associated with different pathological subtypes of renal cell carcinoma (RCC): a multicentre study in China.

    abstract:OBJECTIVE:To investigate whether visceral obesity is associated with certain histological subtypes of renal cell carcinoma (RCC) ina multicentre Chinese cohort. PATIENTS AND METHODS:A kidney tumour database was created using three tertiary centres in China; 487 patients were enrolled presenting with localised RCC and ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Wang HK,Song XS,Cheng Y,Qu YY,Zhang SL,Dai B,Zhang HL,Shen YJ,Zhu YP,Shi GH,Qin XJ,Ma CG,Lin GW,Xiao WJ,Zhu Y,Ye DW

    更新日期:2014-10-01 00:00:00

  • Outcomes of living donor renal transplantation in children with lower urinary tract dysfunction: a comparative retrospective study.

    abstract:OBJECTIVES:To compare outcomes of renal transplantation (RTx) in children with end-stage renal disease (ESRD) resulting from lower urinary tract dysfunction (LUTD) vs other causes. PATIENTS AND METHODS:A database of children (<18 years old) who underwent RTx between May 2008 and April 2012 was reviewed. Patients were ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Saad IR,Habib E,ElSheemy MS,Abdel-Hakim M,Sheba M,Mosleh A,Salah DM,Bazaraa H,Fadel FI,Morsi HA,Badawy H

    更新日期:2016-08-01 00:00:00

  • European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators significantly outperform the Prostate Cancer Prevention Trial (PCPT) 2.0 in the prediction of prostate cancer: a multi-institutional study.

    abstract:OBJECTIVE:To analyse the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomised Study of Screening for Prostate Cancer (ERSPC) Risk Calculator, one of which incorporates prostate volume (ERSPC-RC) and the other of which incorporates prostate volume an...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Foley RW,Maweni RM,Gorman L,Murphy K,Lundon DJ,Durkan G,Power R,O'Brien F,O'Malley KJ,Galvin DJ,Brendan Murphy T,William Watson R

    更新日期:2016-11-01 00:00:00

  • Large-conductance calcium-activated potassium channel activity, as determined by whole-cell patch clamp recording, is decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction.

    abstract:OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Aydin M,Wang HZ,Zhang X,Chua R,Downing K,Melman A,DiSanto ME

    更新日期:2012-10-01 00:00:00

  • Increasing age is not associated with toxicity leading to discontinuation of treatment in patients with urothelial non-muscle-invasive bladder cancer randomised to receive 3 years of maintenance bacille Calmette-Guérin: results from European Organisation

    abstract:OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- ...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Oddens JR,Sylvester RJ,Brausi MA,Kirkels WJ,van de Beek C,van Andel G,de Reijke TM,Prescott S,Alfred Witjes J,Oosterlinck W

    更新日期:2016-09-01 00:00:00

  • Improved sacral neuromodulation in the treatment of the hyperactive detrusor: signal modification in an animal model.

    abstract:OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Seif C,Cherwon E,Martinez Portilló FJ,Alken P,Jünemann KP,Braun PM

    更新日期:2003-05-01 00:00:00

  • Long-term follow-up of the treatment of renal angiomyolipomas after selective arterial embolization with alcohol.

    abstract:STUDY TYPE:Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data. PATIENTS AND METHODS:This retrospective study included 34 patients treated between October 1997 and October 2007 (...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Chick CM,Tan BS,Cheng C,Taneja M,Lo R,Tan YH,Lin SE,Tay KH

    更新日期:2010-02-01 00:00:00

  • Consensus statements on the management of metastatic prostate cancer from the Hong Kong Urological Association and Hong Kong Society of Uro-Oncology.

    abstract::To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPCa) in Hong Kong. A local expert consensus was organized jointly by the two main professional organizations representing prostate cancer specialists in Hong Kong. A total of 12 exper...

    journal_title:BJU international

    pub_type: 共识发展会议,杂志文章


    authors: Poon DM,Chan CK,Chan TW,Cheung FY,Kwong PW,Lee EK,Leung AK,Leung SY,Ma WK,So HS,Tam PC,Ho LY

    更新日期:2018-05-01 00:00:00

  • Brucellar epididymo-orchitis in Saudi Arabia: a retrospective study of 26 cases and review of the literature.

    abstract:OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Memish ZA,Venkatesh S

    更新日期:2001-07-01 00:00:00

  • Effect of positioning on ureteric stone retropulsion: 'gravity works'.

    abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Patel RM,Walia AS,Grohs E,Okhunov Z,Landman J,Clayman RV

    更新日期:2019-01-01 00:00:00

  • Conservative management of giant symptomatic angiomyolipomas in patients with the tuberous sclerosis complex.

    abstract:OBJECTIVE:To present two patients with the tuberous sclerosis complex in whom giant angiomyolipomas (AMLs) were managed conservatively for >20 years, as large (>4 cm) symptomatic AMLs are generally treated with embolization or nephrectomy because of the risks of haemorrhage. PATIENTS AND METHODS:The first patient init...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Danforth TL,Lane BR,Novick AC

    更新日期:2007-10-01 00:00:00

  • One-sided anterior urethroplasty: a new dorsal onlay graft technique.

    abstract:OBJECTIVE:To investigate the feasibility, tolerability, safety and efficacy of using a new surgical technique for the repair of anterior urethral strictures to preserve vascular supply to the urethra and its entire muscular and neurogenic support. PATIENTS AND METHODS:In all, 24 patients (mean age 46 years) underwent ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kulkarni S,Barbagli G,Sansalone S,Lazzeri M

    更新日期:2009-10-01 00:00:00

  • The effect of male circumcision on sexual satisfaction and function, results from a randomized trial of male circumcision for human immunodeficiency virus prevention, Rakai, Uganda.

    abstract:OBJECTIVE:To investigate the relationship between adult male circumcision and sexual satisfaction and function in men, as observational studies on the effect of adult male circumcision on sexual satisfaction show conflicting results. SUBJECTS AND METHODS:We investigated self-reported sexual satisfaction and function a...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Kigozi G,Watya S,Polis CB,Buwembo D,Kiggundu V,Wawer MJ,Serwadda D,Nalugoda F,Kiwanuka N,Bacon MC,Ssempijja V,Makumbi F,Gray RH

    更新日期:2008-01-01 00:00:00

  • A population-based study of urinary symptoms and incontinence: the Canadian Urinary Bladder Survey.

    abstract:OBJECTIVE:To ascertain the prevalence of lower urinary tract symptoms (LUTS) and urinary incontinence (UI) in Canada, using a cross-Canada telephone survey, as there is a wide discrepancy in the reported prevalence of these conditions. SUBJECTS AND METHODS:A random survey with a standardized questionnaire was conducte...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Herschorn S,Gajewski J,Schulz J,Corcos J

    更新日期:2008-01-01 00:00:00