Tumour contact surface area as a predictor of postoperative complications and renal function in patients undergoing partial nephrectomy for renal tumours.


OBJECTIVES:To evaluate the ability of original tumour contact surface area (CSA) to predict postoperative complications and renal function impairment in a series of patients who underwent elective partial nephrectomy (PN) for renal masses. MATERIALS AND METHODS:We analysed the clinical records of 531 consecutive patients who underwent elective PN because of a suspicion of kidney cancer at five academic, high-volume centres between January 2014 and December 2016. Each participating centre evaluated prospectively the radiological images to evaluate the CSA and to assign a PADUA score. Several expert surgeons performed the surgical procedures in each participating centre. Binary logistic regression was used to perform both univariable and multivariable analyses to identify predictors of postoperative complications. Linear regression analysis was used to identify independent predictors of absolute change in estimated glomerular filtration rate (eGFR; ACE). RESULTS:The median (interquartile range) CSA value was 14.2 (7.4-25.1) cm2 . A total of 349 tumours (65.7%) had a CSA ≤ 20 cm2 and the remaining 182 (34.3%) had a CSA > 20 cm2 . PNs were performed using an open approach in 237 (44.6%) cases, a pure laparoscopic approach in 152 cases (28.6%), and a robot-assisted approach in the remaining 142 cases (26.7%). Multivariable analyses found that only age (odds ratio [OR] 1.037, 95% confidence interval [CI] 1.018-1.057) and PADUA score (OR 1.289, 95%CI 1.132-1.469) were independent predictors of postoperative complications. Tumour CSA (OR 1.020, 95%CI 1.010-1.030) was found to be an independent predictor of postoperative complications only when PADUA score was removed from the model. Age (from -0.639 to -0.306; P < 0.001); body mass index (from 0.267 to 1.076; P = 0.001), age-adjusted Charlson score (from -3.193 to -0.259; P = 0.02), preoperative eGFR value (from -0.939 to -0.862; P < 0.001) and tumour CSA (from -0.260 to -0.048; P = 0.005) were found to be independent predictors of ACE. CONCLUSIONS:Tumour CSA is an independent predictor of postoperative renal function. Conversely, at multivariable analysis, PADUA score outperformed tumour CSA to predict postoperative complications after PN. The complexity of The Leslie et al. formula for calculating tumour CSA is a potential limitation with regard to its diffusion and application in clinical practice.




BJU international


Ficarra V,Crestani A,Bertolo R,Antonelli A,Longo N,Minervini A,Novara G,Simeone C,Carini M,Mirone V,Porpiglia F,Collaborators.




Has Abstract


2019-04-01 00:00:00












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    abstract:UNLABELLED:What's known on the subject? and what does the study add?: Only little and partly contradictory data are currently published about the prognostic role of immunohistochemically detectable proliferation-associated biomarkers in surgically treated squamous cell carcinoma of the penis (SCCP), and no data are ava...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: May M,Burger M,Otto W,Hakenberg OW,Wieland WF,May D,Hofstädter F,Götz S,Niessl N,Fritsche HM,Birnkammer K,Gilfrich C,Peter J,Jain A,Koch S,Lebentrau S,Riedmiller H,Rössler W,Denzinger S,Brookman-May S,Gunia S

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  • Regular dilatation is unnecessary after tubularized incised-plate hypospadias repair.

    abstract:OBJECTIVE:To determine if patients who undergo tubularized incised-plate (TIP) urethroplasty need regular dilatation to prevent neourethral strictures or meatal stenosis. PATIENTS AND METHODS:The follow-up of two consecutive series of patients who underwent primary TIP hypospadias repair by one surgeon was reviewed. T...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lorenzo AJ,Snodgrass WT

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  • Effect of statin use on biochemical outcome following radical prostatectomy.

    abstract:OBJECTIVE:•To determine the relationship between statin use and biochemical recurrence (BCR) following radical prostatectomy (RP). PATIENTS AND METHODS:•A retrospective analysis was performed on 3198 RP patients between 1990 and 2008. •Exclusion criteria were neo-adjuvant or adjuvant therapy, follow-up <2 years, and i...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ritch CR,Hruby G,Badani KK,Benson MC,McKiernan JM

    更新日期:2011-10-01 00:00:00

  • Improved quality of life in patients with overactive bladder symptoms treated with solifenacin.

    abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析


    authors: Kelleher CJ,Cardozo L,Chapple CR,Haab F,Ridder AM

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  • Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes.

    abstract:OBJECTIVE:To characterise the clinical, radiological and histological features of mucinous tubular and spindle cell carcinoma (MTSCC), as well as oncological outcomes. PATIENTS AND METHODS:This is a single institution retrospective analysis of all patients with MTSCC from 2002 to 2011. Patients were excluded if MTSCC ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kenney PA,Vikram R,Prasad SR,Tamboli P,Matin SF,Wood CG,Karam JA

    更新日期:2015-07-01 00:00:00

  • The effect of fasting or desmopressin before treatment on the concentration of mitomycin C during intravesical administration.

    abstract:OBJECTIVE:To evaluate two methods of reducing the urine output during treatment (the most easily manipulated variable) in patients undergoing intravesical instillation with mitomycin C, where the concentration-time curve also depends upon dose, diluent volume, residual urine volume, and drug absorption and degradation....

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Cliff AM,Heatherwick B,Scoble J,Parr NJ

    更新日期:2000-10-01 00:00:00

  • Anatomical studies of the neurovascular bundle and cavernosal nerves.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Costello AJ,Brooks M,Cole OJ

    更新日期:2004-11-01 00:00:00

  • Laser robotically assisted nerve-sparing radical prostatectomy: a pilot study of technical feasibility in the canine model.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Gianduzzo T,Colombo JR Jr,Haber GP,Hafron J,Magi-Galluzzi C,Aron M,Gill IS,Kaouk JH

    更新日期:2008-08-05 00:00:00

  • Comparison of hilar clamping and non-hilar clamping partial nephrectomy for tumours involving a solitary kidney.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Wszolek MF,Kenney PA,Lee Y,Libertino JA

    更新日期:2011-06-01 00:00:00

  • Positive influence of robotically assisted laparoscopic prostatectomy on the collaborative-care pathway for open radical prostatectomy.

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    journal_title:BJU international

    pub_type: 杂志文章


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    更新日期:2006-03-01 00:00:00

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Yang WM,Yan ZJ,Ye ZQ,Guo DS

    更新日期:2006-10-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:BJU international

    pub_type: 杂志文章,评审


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    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Safarinejad MR,Hosseini SY,Asgari MA,Dadkhah F,Taghva A

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Melia J,Moss S,Johns L,Contributors in the participating laboratories.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Meria P,Desgrippes A,Fournier R,Arfi C,Antoine C,Martinat L,Teillac P,Le Duc A

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    journal_title:BJU international

    pub_type: 杂志文章


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    pub_type: 杂志文章,随机对照试验


    authors: Sciarra A,Panebianco V,Cattarino S,Busetto GM,De Berardinis E,Ciccariello M,Gentile V,Salciccia S

    更新日期:2012-12-01 00:00:00

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    journal_title:BJU international

    pub_type: 杂志文章


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    更新日期:2006-11-01 00:00:00

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ozkurkcugil C,Yardimoglu M,Dalcik H,Erdogan S,Gokalp A

    更新日期:2004-05-01 00:00:00

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Logie J,Clifford GM,Farmer RD

    更新日期:2005-03-01 00:00:00

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    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: De Dominicis M,Matarazzo E,Capozza N,Collura G,Caione P

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Singh R,Cahill D,Popert R,O'Brien TS

    更新日期:2003-12-01 00:00:00

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    journal_title:BJU international

    pub_type: 杂志文章,评审


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    更新日期:2018-01-01 00:00:00