A canine model of irreversible urethral sphincter insufficiency.

Abstract:

OBJECTIVE:To develop a canine model of external urinary sphincter insufficiency by creating irreversible damage to the sphincter, because there is a need for a reliable and reproducible large animal model for the study of stress urinary incontinence (SUI) caused by deficient sphincter function. MATERIALS AND METHODS:About a quarter of the total external sphincter muscle was removed microsurgically from seven female dogs; three age-matched dogs served as normal controls. The dogs had standard urodynamic and radiographic studies before and at 1, 2, 3, 4 and 7 months after surgery. Three dogs were killed at 4 months and four at 7 months after surgery for tissue analyses. RESULTS:The interventions produced a consistent outcome. Urodynamic studies showed a significant and sustained decrease in sphincter function, which included a static urethral pressure profile, stress urethral profile and detrusor leak-point pressure. Furthermore, in vivo pudendal nerve stimulation and organ-bath studies of the retrieved tissue strips confirmed the loss of sphincter tissue function. Histologically, absence of functional sphincter muscle was evident in the damaged sphincter region. CONCLUSIONS:These results show that a reliable and reproducible canine model of irreversible sphincter insufficiency can be created by microsurgical removal of sphincter muscle tissue. This model of external sphincter insufficiency could be used for evaluating methods (e.g. cell therapies) for treating SUI.

journal_name

BJU Int

journal_title

BJU international

authors

Eberli D,Andersson KE,Yoo JJ,Atala A

doi

10.1111/j.1464-410X.2008.08001.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

248-53

issue

2

eissn

1464-4096

issn

1464-410X

pii

BJU8001

journal_volume

103

pub_type

杂志文章
  • Staging laparoscopic pelvic lymphadenectomy in prostate cancer.

    abstract:OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00931.x

    authors: Shackley DC,Irving SO,Brough WA,O'Reilly PH

    更新日期:1999-02-01 00:00:00

  • Laparoscopic specimen extraction: morcellation.

    abstract:OBJECTIVES:To review our experience with intact extraction and morecellation of nephrectomy specimen, and the advantages and disadvantages of morcellation indicated by current reports. PATIENTS AND METHODS:In a previous study, 56 consecutive patients undergoing radical and simple transperitoneal laparoscopic nephrecto...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410x.2005.05194.x

    authors: Varkarakis I,Rha K,Hernandez F,Kavoussi LR,Jarrett TW

    更新日期:2005-03-01 00:00:00

  • Disease progression and survival in patients with prostate carcinoma and positive lymph nodes after radical retropubic prostatectomy.

    abstract:OBJECTIVE:To determine disease progression and survival in patients with lymph node-positive prostate carcinoma after ascending radical retropubic prostatectomy (RP) and pelvic lymphadenectomy with different forms of postoperative adjuvant treatment. PATIENTS AND METHODS:We analysed 82 patients with lymph node metasta...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06129.x

    authors: Kroepfl D,Loewen H,Roggenbuck U,Musch M,Klevecka V

    更新日期:2006-05-01 00:00:00

  • GreenLight HPS™ 120-W laser vaporization vs transurethral resection of the prostate (

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a sho...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2011.10878.x

    authors: Pereira-Correia JA,de Moraes Sousa KD,Santos JB,de Morais Perpétuo D,Lopes-da-Silva LF,Krambeck RL,Muller VJ,Vaz FP

    更新日期:2012-10-01 00:00:00

  • Short (≤ 1 mm) positive surgical margin and risk of biochemical recurrence after radical prostatectomy.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: It has been suggested that a very short positive margin does not confer additional risk of BCR after radical prostatectomy. This study shows that even very short PSM is associated with increased risk of BCR. OBJECTIVE:To re-evaluate, in a larger coh...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11340.x

    authors: Shikanov S,Marchetti P,Desai V,Razmaria A,Antic T,Al-Ahmadie H,Zagaja G,Eggener S,Brendler C,Shalhav A

    更新日期:2013-04-01 00:00:00

  • Heat-shock protein 25 ameliorates calcium oxalate crystal-mediated oxidative stress in renal epithelial cells.

    abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06478.x

    authors: Patel AB,Robertson WG,Choong S,Hothersall JS

    更新日期:2006-11-01 00:00:00

  • Genes differentially expressed in prostate cancer.

    abstract::Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high-throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2004.04869.x

    authors: Eder IE,Bektic J,Haag P,Bartsch G,Klocker H

    更新日期:2004-05-01 00:00:00

  • Damage to the bladder neck alters autonomous activity and its sensitivity to cholinergic agonists.

    abstract:OBJECTIVE:To identify and describe changes to the motor component of the motor/sensory system, which contributes to sensation during the filling phase of the micturition cycle, as a result of surgically induced bladder pathology, i.e. damage to the bladder neck and outlet obstruction. MATERIALS AND METHODS:Adult male ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07129.x

    authors: de Jongh R,van Koeveringe GA,van Kerrebroeck PE,Markerink-van Ittersum M,de Vente J,Gillespie JI

    更新日期:2007-10-01 00:00:00

  • Lymphovascular invasion and presence of embryonal carcinoma as risk factors for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour (CS I NSGCT). MATERIALS AND METHODS:The PubMed, Embase (OVID) and SCOPUS databases were searched up ...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/bju.14967

    authors: Blok JM,Pluim I,Daugaard G,Wagner T,Jóźwiak K,Wilthagen EA,Looijenga LHJ,Meijer RP,Bosch JLHR,Horenblas S

    更新日期:2020-03-01 00:00:00

  • High-grade prostatic intraepithelial neoplasia is an independent predictor of outcome after radical prostatectomy.

    abstract:OBJECTIVE:To examine the relationship between the presence of high-grade prostatic intraepithelial neoplasia (HGPIN) in retropubic radical prostatectomy (RP) specimens and cancer-specific outcomes, including pathological variables and biochemical disease-free survival (bDFS), as HGPIN shares many histopathological char...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07115.x

    authors: Pierorazio PM,Lambert SM,Matsukhani M,Sprenkle PC,McCann TR,Katz AE,Olsson CA,Benson MC,McKiernan JM

    更新日期:2007-11-01 00:00:00

  • Early observations of the effect of extracorporeal shockwave lithotripsy on blood pressure: a prospective randomized control clinical trial.

    abstract:OBJECTIVE:To determine, in a randomized controlled clinical trial, the effect of extracorporeal shock wave lithotripsy (ESWL) on blood pressure. PATIENTS AND METHODS:The trial included 228 patients with small (< 15 mm) asymptomatic calyceal stones who were randomised to undergo ESWL (113 patients) or to an untreated (...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00571.x

    authors: Elves AW,Tilling K,Menezes P,Wills M,Rao PN,Feneley RC

    更新日期:2000-04-01 00:00:00

  • Urinary levels of substance P and its metabolites are not increased in interstitial cystitis.

    abstract:OBJECTIVES:To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.00990.x

    authors: Campbell DJ,Tenis N,Rosamilia A,Clements JA,Dwyer PL

    更新日期:2001-01-01 00:00:00

  • Society of Robotic Surgery review: recommendations regarding the risk of COVID-19 transmission during minimally invasive surgery.

    abstract:OBJECTIVES:To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoper...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.15105

    authors: Porter J,Blau E,Gharagozloo F,Martino M,Cerfolio R,Duvvuri U,Caceres A,Badani K,Bhayani S,Collins J,Coelho R,Rocco B,Wiklund P,Nathan S,Parra-Davila E,Ortiz-Ortiz C,Maes K,Dasgupta P,Patel V

    更新日期:2020-08-01 00:00:00

  • Impact of medical therapy on transurethral resection of the prostate: two decades of change.

    abstract:OBJECTIVE:• To examine how the introduction of medical therapy for symptomatic benign prostatic hyperplasia (BPH) might have changed the indications, patient characteristics and outcomes in men undergoing transurethral resection of the prostate (TURP) over two decades (1988-2008). PATIENTS AND METHODS:• All patients w...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09737.x

    authors: Izard J,Nickel JC

    更新日期:2011-07-01 00:00:00

  • Satisfaction rate at 1-year follow-up in patients treated with penile implants: data from the multicentre prospective registry INSIST-ED.

    abstract:OBJECTIVES:To investigate scores and predictors of patient satisfaction at 1 year after penile prosthesis implantation (PPI) using the validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. PATIENTS AND METHODS:Analyses were performed for 142 patients prospectively included in the natio...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.14462

    authors: Capogrosso P,Pescatori E,Caraceni E,Mondaini N,Utizi L,Cai T,Salonia A,Palmieri A,Deho' F

    更新日期:2019-02-01 00:00:00

  • The ageing male and erectile dysfunction.

    abstract::Erectile dysfunction is common in the ageing man and reliable therapies are needed. The pathophysiology of erectile dysfunction in this group mainly includes chronic ischaemia, which triggers the deterioration of cavernosal smooth muscle and the development of corporeal fibrosis. Assessing the ageing man with erectile...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1464-410x.2003.04378.x

    authors: Montorsi F,Briganti A,Salonia A,Deho' F,Zanni G,Cestari A,Guazzoni G,Rigatti P,Stief C

    更新日期:2003-09-01 00:00:00

  • The role of targeted prophylactic antimicrobial therapy before transrectal ultrasonography-guided prostate biopsy in reducing infection rates: a systematic review.

    abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.13402

    authors: Cussans A,Somani BK,Basarab A,Dudderidge TJ

    更新日期:2016-05-01 00:00:00

  • Evaluation of ureteric contraction: a comparison among ring, spiral-cut and longitudinal segments.

    abstract:OBJECTIVE:To determine the optimal contractile response of isolated ureters to inflammatory mediators and neurotransmitters by evaluating four common methods of ureteric suspension. MATERIALS AND METHODS:Ureters from adult domestic swine were placed immediately in Krebs buffer and cut into 4-5 mm segments. Four method...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00865.x

    authors: Jerde TJ,Saban R,Nakada SY

    更新日期:1999-01-01 00:00:00

  • Radical cystectomy pentafecta: a proposal for standardisation of outcomes reporting following robot-assisted radical cystectomy.

    abstract:OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary di...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14861

    authors: Cacciamani GE,Winter M,Medina LG,Ashrafi AN,Miranda G,Tafuri A,Landsberger H,Lin-Brande M,Rajarubendra N,De Castro Abreu A,Berger A,Aron M,Gill IS,Desai MM

    更新日期:2020-01-01 00:00:00

  • Comparison of an adjustable anchored single-incision mini-sling, Ajust(®) , with a standard mid-urethral sling, TVT-O(TM) : a health economic evaluation.

    abstract:OBJECTIVES:To assess the cost, quality of life (QoL) and cost-effectiveness of a single-incision mini-sling (SIMS; Ajust(®) , C. R. Bard Inc., New Providence, NJ, USA) compared with a standard mid-urethral sling (SMUS; TVT-O™, Ethicon Inc., Somerville, NJ, USA) in the surgical management of female stress urinary incont...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bju.12388

    authors: Boyers D,Kilonzo M,Mostafa A,Abdel-Fattah M

    更新日期:2013-12-01 00:00:00

  • Percutaneous cryoablation of renal masses: Washington University experience of treating 129 tumours.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11432.x

    authors: Kim EH,Tanagho YS,Bhayani SB,Saad NE,Benway BM,Figenshau RS

    更新日期:2013-05-01 00:00:00

  • Cystometric evaluation of reconstructed classical bladder exstrophy.

    abstract:OBJECTIVE:To evaluate the association of urodynamic variables with continence and upper tract status after reconstruction in patients with classical bladder exstrophy. PATIENTS AND METHODS:Thirty-one patients with bladder exstrophy were assessed 1 year after a modified bladder neck reconstruction. The evaluation inclu...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02338.x

    authors: Dave S,Grover VP,Agarwala S,Mitra DK,Bhatnagar V

    更新日期:2001-09-01 00:00:00

  • Evolution of robot-assisted orthotopic ileal neobladder formation: a step-by-step update to the University of Southern California (USC) technique.

    abstract:OBJECTIVE:To describe our, step-by-step, technique for robotic intracorporeal neobladder formation. PATIENTS AND METHODS:The main surgical steps to forming the intracorporeal orthotopic ileal neobladder are: isolation of 65 cm of small bowel; small bowel anastomosis; bowel detubularisation; suture of the posterior wal...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13611

    authors: Chopra S,de Castro Abreu AL,Berger AK,Sehgal S,Gill I,Aron M,Desai MM

    更新日期:2017-01-01 00:00:00

  • Serous-lined, stapled pouch wall plication: initial results of a simple and quick novel continence mechanism in troubleshooting secondary to continent cutaneous urinary diversion.

    abstract:OBJECTIVES:To report a novel and straightforward technique of a secondary continent outlet for continent cutaneous urinary diversion (CCUD) reservoirs without the need for further bowel resection, reducing operating time and length of hospitalization. PATIENTS AND METHODS:From 2015 to 2017, six patients with unreconst...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13979

    authors: Riedmiller H,Kocot A,Kalogirou C

    更新日期:2018-01-01 00:00:00

  • Sexual function before and after various treatments for symptomatic benign prostatic hyperplasia.

    abstract:OBJECTIVE:To determine the effect of various treatments for benign prostatic hyperplasia (BPH) on sexual function. PATIENTS AND METHODS:In a longitudinal multicentre study carried out in the Netherlands, 670 consecutive patients with BPH (aged > or = 50 years) were examined at baseline and 9 months after inclusion. Al...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-4096.2001.01817.x

    authors: Leliefeld HH,Stoevelaar HJ,McDonnell J

    更新日期:2002-02-01 00:00:00

  • A tertiary experience of vesico-vaginal and urethro-vaginal fistula repair: factors predicting success.

    abstract:OBJECTIVE:To review the outcomes of all patients referred with vesico-vaginal (V VF) and urethro-vaginal (UVF) fistulae to a tertiary centre, and to investigate the patient, fistula and surgical factors relevant to success. PATIENTS AND METHODS:We reviewed retrospectively the case-notes of 41 consecutive patients (32 ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08237.x

    authors: Ockrim JL,Greenwell TJ,Foley CL,Wood DN,Shah PJ

    更新日期:2009-04-01 00:00:00

  • Retrospective cohort study on patterns of care and outcomes of surgical treatment for lower urinary-genital tract fistula among English National Health Service hospitals between 2000 and 2009.

    abstract:OBJECTIVES:To examine patterns of care among women with urogenital fistula treated in the English National Health Service (NHS) between 2000 and 2009. To assess whether failure of repair was associated with hospital or surgeon workload. PATIENTS AND METHODS:We conducted a retrospective cohort study using data from Hos...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11483.x

    authors: Cromwell D,Hilton P

    更新日期:2013-04-01 00:00:00

  • Concentric needle electrodes are superior to perineal surface-patch electrodes for electromyographic documentation of urethral sphincter relaxation during voiding.

    abstract:OBJECTIVE:To compare interpretations of electromyographic (EMG) recordings from perineal surface patch electrodes (PSPEs) to those from urethral concentric needle electrodes (CNEs) during voiding. PATIENTS AND METHODS:Consenting women underwent urodynamic testing with a 30 G, 3.8 cm CNE at the 12 o'clock position in t...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.05890.x

    authors: Mahajan ST,Fitzgerald MP,Kenton K,Shott S,Brubaker L

    更新日期:2006-01-01 00:00:00

  • Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy.

    abstract:OBJECTIVE:To report a contemporary series of patients with xanthogranulomatous pyelonephritis (XGP, an inflammatory condition of the kidney that has traditionally been treated with open nephrectomy, ON), managed with either ON or laparoscopic nephrectomy (LN), as early reports suggest that the benefits of LN do not ext...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08547.x

    authors: Guzzo TJ,Bivalacqua TJ,Pierorazio PM,Varkarakis J,Schaeffer EM,Allaf ME

    更新日期:2009-11-01 00:00:00

  • Anaemia in men receiving combined finasteride and flutamide therapy for advanced prostate cancer.

    abstract:OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of a...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00844.x

    authors: Ornstein DK,Beiser JA,Andriole GL

    更新日期:1999-01-01 00:00:00