Abstract:
:Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high-throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular basis of prostate disease. Many candidate genes have been identified so far which have a more or less strong effect on prostate cancer. This vast number of gene expression changes show that it is unlikely that only one gene promotes prostate cancer. Conversely, it seems more likely that a broad network of molecular changes is involved in the complex cascade of events which lead to tumour formation and progression, respectively. A few of these novel molecular targets are currently under clinical evaluation. This paper gives an overview of several interesting candidate genes which may be useful as improved biomarkers for diagnosis or as targets for developing novel treatment methods.
journal_name
BJU Intjournal_title
BJU internationalauthors
Eder IE,Bektic J,Haag P,Bartsch G,Klocker Hdoi
10.1111/j.1464-410X.2004.04869.xkeywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
1151-5issue
8eissn
1464-4096issn
1464-410Xpii
BJU4869journal_volume
93pub_type
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更新日期:2013-09-01 00:00:00