Genes differentially expressed in prostate cancer.

Abstract:

:Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high-throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular basis of prostate disease. Many candidate genes have been identified so far which have a more or less strong effect on prostate cancer. This vast number of gene expression changes show that it is unlikely that only one gene promotes prostate cancer. Conversely, it seems more likely that a broad network of molecular changes is involved in the complex cascade of events which lead to tumour formation and progression, respectively. A few of these novel molecular targets are currently under clinical evaluation. This paper gives an overview of several interesting candidate genes which may be useful as improved biomarkers for diagnosis or as targets for developing novel treatment methods.

journal_name

BJU Int

journal_title

BJU international

authors

Eder IE,Bektic J,Haag P,Bartsch G,Klocker H

doi

10.1111/j.1464-410X.2004.04869.x

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

1151-5

issue

8

eissn

1464-4096

issn

1464-410X

pii

BJU4869

journal_volume

93

pub_type

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