USANZ: Time-trends in use and impact on outcomes of perioperative chemotherapy in patients treated with radical cystectomy for urothelial bladder cancer.

Abstract:

OBJECTIVE:To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. PATIENTS AND METHODS:Using electronic and paper medical records, 89 patients were identified who underwent radical cystectomy with or without perioperative chemotherapy between 2004 and 2011 at Austin Health in Melbourne, Australia. Patient demographics, clinico-pathological characteristics and details of recurrence and death were assessed by retrospective chart review. Survival analysis was carried out using the Kaplan Meier method, with the impact of predictors assessed using Cox proportional hazard models. RESULTS:The median (range) age of this cohort was 65 (37-84) years, and 66 (74%) patients were male. Pathologic features included 68 (76%) pure UC, 21 (24%) mixed UC and 84 (94%) high grade tumours. On clinical staging, 63 (71%) patients had muscle-invasive bladder cancer (cT-stage ≥ T2), of whom 11 (17%) received neoadjuvant chemotherapy, with an increasing trend in use over time. Following radical cystectomy, pT-stage ≥ T3 and/or node positive were identified in 35 (39%) patients, of whom 16 (46%) received adjuvant chemotherapy. In addition, five patients with stage pT2 received adjuvant chemotherapy. Of the total cohort of patients, 31 (35%) suffered recurrences, and 33 died, 27 from urothelial carcinoma. On multivariate analysis, after adjusting for age, pT-stage and pN-stage, perioperative chemotherapy was associated with a significantly lower risk of recurrence [relative risk (RR) 0.41, p < 0.05], but not death from cancer or all causes. CONCLUSIONS:Perioperative chemotherapy, and in particular neoadjuvant chemotherapy, remains relatively under-utilised at our institution despite recent increases. The significant reduction in the risk of recurrence following treatment with perioperative chemotherapy with radical cystectomy highlights the importance of multi-modality treatment in bladder UC. Identifying barriers to more widespread implementation of perioperative chemotherapy is critical for enhancing outcomes in patients with bladder UC.

journal_name

BJU Int

journal_title

BJU international

authors

Liew MS,Azad A,Tafreshi A,Eapen R,Bolton D,Davis ID,Sengupta S

doi

10.1111/bju.12384

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

74-82

eissn

1464-4096

issn

1464-410X

journal_volume

112 Suppl 2

pub_type

杂志文章
  • Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age.

    abstract:OBJECTIVES:To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (SEPs) after electrical stimulation of different locations in the lower urinary tract (LUT) in a cohort of middle-aged healthy women. SUBJECTS AND METHODS:In a group of 10 healthy middle-aged women [mean (sd...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13066

    authors: Gregorini F,Knüpfer SC,Liechti MD,Schubert M,Curt A,Kessler TM,Mehnert U

    更新日期:2015-04-01 00:00:00

  • Severe perineal pain after enterocystoplasty in bladder exstrophy.

    abstract:OBJECTIVE:To describe a previously unreported complication (severe perineal pain) after bladder reconstruction and enterocystoplasty in patients with bladder exstrophy. PATIENTS AND METHODS:The notes were reviewed retrospectively for four patients (two boys and two girls) with classical bladder exstrophy who had sever...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2003.04741.x

    authors: Phelps SR,Malone PS

    更新日期:2004-04-01 00:00:00

  • Staging laparoscopic pelvic lymphadenectomy in prostate cancer.

    abstract:OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00931.x

    authors: Shackley DC,Irving SO,Brough WA,O'Reilly PH

    更新日期:1999-02-01 00:00:00

  • Predicting survival after radical cystectomy for bladder cancer.

    abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2008.07594.x

    authors: Margulis V,Lotan Y,Montorsi F,Shariat SF

    更新日期:2008-07-01 00:00:00

  • Urodynamic findings before and after noninvasive management of bladder calculi.

    abstract:OBJECTIVES:To determine the most frequent urodynamic observations associated with bladder calculi, and to assess whether the presence of calculi alters these observations. PATIENTS AND METHODS:Fifty patients with bladder stones were included in a prospective study in which two urodynamic tests were used, one at inclus...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.04815.x

    authors: Millán-Rodríguez F,Errando-Smet C,Rousaud-Barón F,Izquierdo-Latorre F,Rousaud-Barón A,Villavicencio-Mavrich H

    更新日期:2004-06-01 00:00:00

  • Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort.

    abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09321.x

    authors: Mishra GD,Cardozo L,Kuh D

    更新日期:2010-10-01 00:00:00

  • Have phosphodiesterase-5 inhibitors changed the indications for penile implants?

    abstract::OBJECTIVE To evaluate the indications for penile prosthesis implantation in the treatment of erectile dysfunction (ED) before and after the introduction of sildenafil. PATIENTS AND METHODS Penile prosthesis implantation was indicated in 144 men with ED at our institution between 1992 and 2007; 83 (55.6%) accepted the ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08356.x

    authors: Cortés-González JR,Glina S

    更新日期:2009-06-01 00:00:00

  • Development of a voided urine assay for detecting prostate cancer non-invasively: a pilot study.

    abstract:OBJECTIVE:To validate a hypothesis that prostate cancer can be detected non-invasively by a simple and reliable assay by targeting genomic VPAC receptors expressed on malignant prostate cancer cells shed in voided urine. PATIENTS/SUBJECTS AND METHODS:VPAC receptors were targeted with a specific biomolecule, TP4303, de...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13775

    authors: Trabulsi EJ,Tripathi SK,Gomella L,Solomides C,Wickstrom E,Thakur ML

    更新日期:2017-06-01 00:00:00

  • Low pretreatment total testosterone (< 3 ng/mL) predicts extraprostatic disease in prostatectomy specimens from patients with preoperative localized prostate cancer.

    abstract:OBJECTIVE:• To investigate the relationship between pretreatment testosterone levels and pathological specimen characteristics, by prospectively examining serum androgen concentrations in a well-studied cohort of patients who underwent radical prostatectomy (RP) for localized prostate cancer. PATIENTS AND METHODS:• A ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09816.x

    authors: Xylinas E,Ploussard G,Durand X,Fabre A,Salomon L,Allory Y,Vordos D,Hoznek A,Abbou CC,de la Taille A

    更新日期:2011-05-01 00:00:00

  • Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer.

    abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2011.10371.x

    authors: Boström PJ,Alkhateeb S,Trottier G,Athanasopoulos PZ,Mirtti T,Kortekangas H,Laato M,van Rhijn B,van der Kwast T,Fleshner NE,Jewett MA,Finelli A,Zlotta AR

    更新日期:2012-01-01 00:00:00

  • Testicular-sparing surgery: a reasonable option in selected patients with testicular lesions.

    abstract:OBJECTIVE:To describe our experience of inguinal exploration in patients who had a reasonable chance of having a benign testicular lesion. PATIENTS AND METHODS:From 1995 to 2002, 11 patients (mean age 43 years, range 27-63) with testicular masses that were suspected to be benign underwent inguinal exploration. RESULT...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04080.x

    authors: Passarella M,Usta MF,Bivalacqua TJ,Hellstrom WJ,Davis R

    更新日期:2003-03-01 00:00:00

  • Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer.

    abstract:OBJECTIVE:To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. RESULTS:P...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2007.07173.x

    authors: Aragon-Ching JB,Gillespie J,Price DK,Chuaqui R,Rodriguez-Canales J,Steinberg SM,Dahut WL,Figg WD

    更新日期:2007-12-01 00:00:00

  • Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators.

    abstract:OBJECTIVE:To compare changes in regional cerebral blood flow (rCBF), using positron emission tomography (PET), during chronic and acute sacral neuromodulation (SN). SN is an effective long-term treatment for chronic urge incontinence due to urinary bladder hyperactivity, as sensory nerves, spinal and supraspinal struct...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06521.x

    authors: Blok BF,Groen J,Bosch JL,Veltman DJ,Lammertsma AA

    更新日期:2006-12-01 00:00:00

  • Molecular model for neuroendocrine prostate cancer progression.

    abstract::Prostate cancer (PCa) is the most common form of cancer in men in the developed world and the second leading cause of cancer-related deaths. While advanced PCa is initially controlled with hormonal therapies targeting the androgen receptor (AR) pathway, recurrence occurs because of the emergence of lethal castration-r...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14207

    authors: Chen R,Dong X,Gleave M

    更新日期:2018-10-01 00:00:00

  • Emphysematous cystitis: a review of 135 cases.

    abstract:OBJECTIVE:To review recently published data on emphysematous cystitis (EC), a potentially life-threatening condition characterized by air within the bladder wall, and that most typically affects middle-aged diabetic women. METHODS:All articles published in English between 1956 and 2006 were identified using a Medline ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2007.06930.x

    authors: Thomas AA,Lane BR,Thomas AZ,Remer EM,Campbell SC,Shoskes DA

    更新日期:2007-07-01 00:00:00

  • The Z-shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients.

    abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To evaluate the results in terms of functional results and morbidity of Z-shaped ileal neobladder performed in a single center. PATIENTS AND METHODS:329 consecutive male patients who had an orthotopic bladder replacement using the Z-shaped...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.10000.x

    authors: Neuzillet Y,Yonneau L,Lebret T,Herve JM,Butreau M,Botto H

    更新日期:2011-08-01 00:00:00

  • Fertility managment in testicular cancer: the need to establish a standardized and evidence-based patient-centric pathway.

    abstract:OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14455

    authors: Moody JA,Ahmed K,Yap T,Minhas S,Shabbir M

    更新日期:2019-01-01 00:00:00

  • One-carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats.

    abstract:OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14385

    authors: Mohammadi P,Hassani-Bafrani H,Tavalaee M,Dattilo M,Nasr-Esfahani MH

    更新日期:2018-09-01 00:00:00

  • Retrograde ureteroscopy for distal ureteric stone removal in children.

    abstract:OBJECTIVE:To compare the efficacy and safety of ureteroscopy plus intracorporeal lithotripsy (ULT) with extracorporeal shock wave lithotripsy (ESWL) for treating distal ureteric calculi in childhood, as such stones are commonly treated by ESWL as the first option in adults but there is no agreement on the method of tre...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2005.05464.x

    authors: De Dominicis M,Matarazzo E,Capozza N,Collura G,Caione P

    更新日期:2005-05-01 00:00:00

  • Percutaneous cryoablation of solitary sporadic renal cell carcinomas.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Percutaneous renal cryoablation is a safe and effective treatment for patients with small renal masses, who are poor surgical candidates. Oncological outcomes from previous percutaneous ablation studies are difficult to interpret because of the large ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11230.x

    authors: Schmit GD,Thompson RH,Kurup AN,Weisbrod AJ,Carter RE,Callstrom MR,Atwell TD

    更新日期:2012-12-01 00:00:00

  • Heat-shock protein 25 ameliorates calcium oxalate crystal-mediated oxidative stress in renal epithelial cells.

    abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06478.x

    authors: Patel AB,Robertson WG,Choong S,Hothersall JS

    更新日期:2006-11-01 00:00:00

  • The control of haemolysis during transurethral resection of the prostate when water is used for irrigation: monitoring absorption by the ethanol method.

    abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00979.x

    authors: Hultén JO,Tran VT,Pettersson G

    更新日期:2000-12-01 00:00:00

  • Fournier's gangrene in a modern surgical setting: improved survival with aggressive management.

    abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-410x.1999.00140.x

    authors: Corman JM,Moody JA,Aronson WJ

    更新日期:1999-07-01 00:00:00

  • Focal cryotherapy for localized prostate cancer: a report from the national Cryo On-Line Database (COLD) Registry.

    abstract:UNLABELLED:Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Selective destruction of targeted prostate tissue is now technically feasible. Much has been theorized but little is known about the proper patient selection or treatment outcomes to determine if this...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10578.x

    authors: Ward JF,Jones JS

    更新日期:2012-06-01 00:00:00

  • A canine model of irreversible urethral sphincter insufficiency.

    abstract:OBJECTIVE:To develop a canine model of external urinary sphincter insufficiency by creating irreversible damage to the sphincter, because there is a need for a reliable and reproducible large animal model for the study of stress urinary incontinence (SUI) caused by deficient sphincter function. MATERIALS AND METHODS:A...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08001.x

    authors: Eberli D,Andersson KE,Yoo JJ,Atala A

    更新日期:2009-01-01 00:00:00

  • Design and evaluation of an image-guidance system for robot-assisted radical prostatectomy.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Systems for image guidance during laparoscopic surgery can be broadly defined as systems that enable the surgeon to refer to preoperatively gathered information during the procedure. For a laparoscopic system the preoperative information can be overl...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11692.x

    authors: Thompson S,Penney G,Billia M,Challacombe B,Hawkes D,Dasgupta P

    更新日期:2013-06-01 00:00:00

  • A longitudinal study of anxiety, depression and distress as predictors of sexual and urinary quality of life in men with prostate cancer.

    abstract:OBJECTIVE:To evaluate the prevalence of depression, anxiety and distress among active surveillance (AS) and radical prostatectomy (RP) patients. To evaluate the impact of these symptoms at baseline on urinary and sexual quality of life at follow-up. PATIENTS AND METHODS:Patients managed with AS or RP who completed val...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12209

    authors: Punnen S,Cowan JE,Dunn LB,Shumay DM,Carroll PR,Cooperberg MR

    更新日期:2013-07-01 00:00:00

  • Patterns of prescription and adherence to European Association of Urology guidelines on androgen deprivation therapy in prostate cancer: an Italian multicentre cross-sectional analysis from the Choosing Treatment for Prostate Cancer (CHOICE) study.

    abstract:OBJECTIVE:To evaluate both the patterns of prescription of androgen deprivation therapy (ADT) in patients with prostate cancer (PCa) and the adherence to European Association of Urology (EAU) guidelines for ADT prescription. METHODS:The Choosing Treatment for Prostate Cancer (CHOICE) study was an Italian multicentre c...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13307

    authors: Morgia G,Russo GI,Tubaro A,Bortolus R,Randone D,Gabriele P,Trippa F,Zattoni F,Porena M,Mirone V,Serni S,Del Nero A,Lay G,Ricardi U,Rocco F,Terrone C,Pagliarulo A,Ludovico G,Vespasiani G,Brausi M,Simeone C,Novell

    更新日期:2016-06-01 00:00:00

  • Development and validation of an Arabic version of the International Prostate Symptom Score.

    abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08984.x

    authors: Hammad FT,Kaya MA

    更新日期:2010-05-01 00:00:00

  • Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging.

    abstract:OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09808.x

    authors: Delongchamps NB,Rouanne M,Flam T,Beuvon F,Liberatore M,Zerbib M,Cornud F

    更新日期:2011-05-01 00:00:00