Abstract:
UNLABELLED:Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Selective destruction of targeted prostate tissue is now technically feasible. Much has been theorized but little is known about the proper patient selection or treatment outcomes to determine if this organ preserving approach to prostate cancer has merit for further study and diffusion into wider practice. Herein we present the largest retrospective registry report of men treated with sub-total prostate cryotherapy in order to begin to understand how this treatment is being applied despite the paucity of data. OBJECTIVES:• To identify recent trends in focal cryotherapy from a prospectively maintained treatment registry. • To describe treatment outcomes after uncontrolled application of focally ablative techniques within community practice. MATERIALS AND METHODS:• We conducted an analysis of the COLD Registry to identify patients treated with partial gland prostate cryoablation between 1997 and 2007. • Preoperative characteristics and postoperative cancer-specific and functional outcomes were assembled for analysis. RESULTS:• The COLD Registry contained information for 5853 patients and focal cryotherapy was the codified procedure in 1160 patients (19.8%). • A dramatic increase in focal treatments was observed, from 46 in 1999 to 567 in 2005 (P < 0.01). • The biochemical recurrence-free rate (ASTRO definition) at 36 months was 75.7%. • Prostate biopsy, performed in 164/1160 of patients (14.1%), was positive in 43 (26.3%) of those suspected of cancer recurrence, but in only 3.7% (43/1160) of treated patients. • Urinary continence (defined as use of 0 pads) was 98.4%. Maintenance of spontaneous erections was 58.1%. Prolonged urinary retention (>30 days) occurred in six (1.1%) patients. Rectourethral fistula was observed in one (0.1%) patient. CONCLUSIONS:• Focal cryoablation is increasingly used for selected patients with prostate cancer. • Oncological efficacy in the present series appears similar to that of whole-gland cryoablation. • The impact of focal cryoablation on urinary, sexual and bowel function appears to be less than that of radical therapies, although preservation of sexual function is not as high as might be expected.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ward JF,Jones JSdoi
10.1111/j.1464-410X.2011.10578.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
1648-54issue
11eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
杂志文章abstract:OBJECTIVE:To determine the concentration of nitric oxide (NO) and the location and change in the expression of NO synthase (NOS) isoforms in the testes of subfertile men with varicocele, and to compare the NO concentration or NOS expression with clinical variables, to determine the role of NO on the pathophysiology of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06800.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To determine whether men with premature ejaculation who fail to respond to 25 mg clomipramine as needed improve when taking 10-30 mg clomipramine daily. SUBJECTS AND METHODS:Four men with premature ejaculation whose ejaculation latencies increased minimally or not at all when taking 25 mg clomipramine as nee...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00112.x
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence of bone fractures in patients receiving luteinizing hormone-releasing hormone agonists (LHRH-a) for prostate cancer (in whom a continued low testosterone level after the long-term administration of these drugs reduces bone mineral density), and thus determine the risk of secondary...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00774.x
更新日期:2000-09-01 00:00:00
abstract::We performed a systematic literature review to assess the current status of a totally intracorporeal robot-assisted radical cystectomy (RARC) approach. The current 'gold standard' for radical cystectomy remains open radical cystectomy. RARC has lagged behind robot-assisted prostatectomy in terms of adoption and percei...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12558
更新日期:2014-09-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and what does the study add?: As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11766.x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over-expressed in several cancer cells, in bladder cancer and its association with patient prognosis and the response to adjuvant therapy. PATIENTS AND METHODS:In all, 67 bladder tissue specimens were obtained f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08099.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the levels of glycosylated haemoglobin (HbA1c) and the severity of erectile dysfunction (ED) in men with diabetes mellitus (DM). PATIENTS AND METHODS:This cross-sectional study included sexually active men with a diagnosis of DM attending a urological medical centre from J...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05349.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:• To examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively. PATIENTS AND METHODS:• A cross-sectional population-representative survey was conducted via the Internet in ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10013.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine any bias by authors of different nationalities in their citation rate of selected urological journals in papers published in the British Journal of Urology and the Journal of Urology. METHODS:Using a simple computer program and text files of accepted reports in the BJU, or those available on CD-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00267.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To measure the prevalence of nocturia in general practice and to determine which factors are associated with nocturia. SUBJECTS AND METHODS:Data were collected from 3048 elderly men, who completed a questionnaire that was sent to every man aged 55-75 years in 21 general practices in Maastricht (the Netherlan...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2006.06029.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00010.x
更新日期:1999-04-01 00:00:00
abstract::Three-dimensional (3D) printing or additive manufacturing is a new technology that has seen rapid development in recent years with decreasing costs. 3D printing allows the creation of customised, finely detailed constructs. Technological improvements, increased printer availability, decreasing costs, improved cell cul...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14928
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:A comparison of laparoscopic and open donor nephrectomy is presented by authors from the UK. They found that the laparoscopic approach could safely be offered to patients treated in experienced units and after adequate training fo the surgeon, with no increase in complications or decrease in efficacy. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05264.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To report the medium-term results at our institution of repairing long bulbar urethral strictures with buccal mucosal grafts. PATIENTS AND METHODS:Between January 2003 and June 2007, a buccal mucosa graft repair was used in 34 patients with recurrent bulbar strictures >2 cm. The follow-up included uroflowme...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08848.x
更新日期:2010-04-01 00:00:00
abstract::• Synthetic mid-urethral slings (MUSs) are considered the first choice surgical procedure for stress urinary incontinence. Recent publications have raised concerns about the efficacy of third generation single-incision mini-slings. The present paper is a systematic review of studies reporting 12-month outcomes after t...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10333.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of urethral ultrasonography (sono-urethrography, SUG) in determining the length of anterior urethral strictures, and for predicting the degree of spongiofibrosis. PATIENTS AND METHODS:In all, 52 patients with anterior urethral strictures detected on retrograde urethrography (RUG) wer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06234.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To characterise the surgical feasibility and outcomes of robot-assisted radical cystectomy (RARC) for pathological T4 bladder cancer. PATIENTS AND METHODS:Retrospective evaluation of a prospectively maintained International Radical Cystectomy Consortium database was conducted for 1118 patients who underwent ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12569
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:To report an audit of preoperative staging variables, case selection, stage migration and prostate-specific antigen (PSA) recurrence at five large centres in the south of England. To establish PSA outcome values after radical prostatectomy for clinically localized prostate cancer in the UK, and enable approp...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2003.04715.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To describe the pattern and prevalence of lower urinary tract symptoms (LUTS) and related help-seeking behaviour in men of South Asian origin living in the UK, and to compare this to the white population. SUBJECTS AND METHODS:Data were obtained as part of the Leicestershire MRC Incontinence Study. Community-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06377.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To verify the sensitivity of the bladder tumour antigen (BTAstat, Bard Urological, Covington, GA) test against the sensitive procedure of photodynamic diagnosis (PDD), in which 5-aminolaevulinic acid (5-ALA, a precursor of fluorescent porphyrins) is absorbed by the tumour and detected by ultraviolet cystoscop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02717.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the possible influence of non-pharmacological interventions, such as compressive bandages and intermittent pneumatic compression (IPC), on leg oedema and nocturnal polyuria (NP), and the possible interrelation between both pathologies in patients with spinal cord injury (SCI), as patients with SC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14672
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To analyse the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomised Study of Screening for Prostate Cancer (ERSPC) Risk Calculator, one of which incorporates prostate volume (ERSPC-RC) and the other of which incorporates prostate volume an...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.13437
更新日期:2016-11-01 00:00:00
abstract::Laparoendoscopic single-site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES™) are new approaches to minimally invasive surgery. A number of technical challenges need to be overcome and new developments of equipment are required before widespread acceptance of either modality occurs. In this ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09665.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To determine the level of malondialdehyde (MDA), an indirect indicator of lipid peroxidation-induced injury by reactive oxygen species, in testicular biopsy specimens from infertile patients with and without varicocele. PATIENTS AND METHODS:Levels of MDA were measured in the testicular biopsy specimens from ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00755.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:• To systematically review and compare the economic burden of open radical cystectomy (ORC) vs robot-assisted laparoscopic radical cystectomy (RALRC) with pelvic lymph node dissection and urinary diversion. PATIENTS AND METHODS:• A Medline search was conducted to identify English language articles regarding ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10468.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07442.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To determine the effectiveness of cancer control afforded by radical prostatectomy (RP) in patients with clinical stage T3 prostate cancer. PATIENTS AND METHODS:We retrospectively reviewed data for patients treated by RP for clinical stage T3 prostate cancer between 1995 and 2005. The following case characte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08208.x
更新日期:2009-05-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (outcomes) Level of Evidence 2b What's known on the subject? and What does the study add? Data on the oncological outcomes in patients undergoing salvage cystectomy for recurrent disease following bladder-sparing treatment is limited and mostly based on case reports. We present the clini...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11438.x
更新日期:2013-03-01 00:00:00