Abstract:
OBJECTIVES:To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal bladder function. PATIENTS AND METHODS:Catheter urine was collected from 13 patients and 10 controls during a water diuresis ( approximately 10 mL/min) before and after instilling the bladder with 100 mL of water. The contribution of the bladder wall to urinary substance P peptides was assessed by measuring the change in substance P peptide levels after 2 min of bladder stasis before and after instillation. RESULTS:Absolute substance P excretion rates were similar in patients with interstitial cystitis and controls; 2 min of bladder stasis reduced the substance P excretion rate (P = 0.03) and increased the excretion rate of substance P metabolites (P = 0.01). CONCLUSIONS:The release of substance P from the bladder wall was not increased in patients with interstitial cystitis.
journal_name
BJU Intjournal_title
BJU internationalauthors
Campbell DJ,Tenis N,Rosamilia A,Clements JA,Dwyer PLdoi
10.1046/j.1464-410x.2001.00990.xkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
35-8issue
1eissn
1464-4096issn
1464-410Xpii
bju990journal_volume
87pub_type
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