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Construction of tissue-engineered corpus cavernosum with muscle-derived stem cells and transplantation in vivo.

Abstract：

OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedure. MDSCs were separated and purified using a digestion method and Preplate technique, then seeded on ACCMs at a concentration of 30 × 10(6) cells/mL to construct TECCs. After 5 days of culture, seeded ACCMs were implanted with albuginea of rabbits. The implants were retrieved at 2, 4 and 6 months after implantation. • Histochemistry, immunohistochemisry and scanning electron microscopy were performed to analyse the morphological characteristics of the TECCs. RESULTS:• The decellularization process successfully extracted all cellular components while preserving the original collagen fibres. • Histological analyses of the explants at all time points in the experimental group had more cells and better arranged growth than the control group. α-Smooth muscle actin and endothelial nitric oxide synthase-positive cells were more prevalent in the experimental group. CONCLUSION:• Our study showed that MDSCs can be seeded on three-dimensional ACCM scaffolds and develop tissues that are similar to native normal corpus cavernosum.

journal_name

BJU Int

journal_title

BJU international

authors

Ji C,Min F,Liang W,Chen Y,Pan S,Bin L,Chen S,Wei Z,He T,Gu Y,Zhang J

doi

10.1111/j.1464-410X.2010.09695.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1638-46

issue

10

eissn

1464-4096

issn

1464-410X

journal_volume

107

pub_type

杂志文章

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