Abstract:
OBJECTIVE:To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse of testicular germ cell tumours (TGCTs), in the follow-up of TGCTs for detecting tumour relapse, as it has role as a prognostic factor but its role in follow-up is less certain. PATIENTS AND METHODS:We retrospectively reviewed 499 patients with TGCT who were followed from 1 January 2004 to 31 December 2005, with no clinical evidence of disease after a complete response to treatment or on surveillance for stage I disease. RESULTS:Of patients attending for follow-up or surveillance, in 26 of 1777 (1.4%) "patient-visits" there was a high LDH level related to disease, and in 137 of 1777 (7.7%) such visits there was a high LDH from unrelated causes. Of the 499 patients who were followed, 15 relapsed; the LDH level was high in six of 15 who relapsed, with LDH being one of the first elevated markers in four and the only elevated marker in one (seminoma). Of the 449 patients, 41 (9.1%) had a persistent false-positive increase in LDH. The sensitivity of LDH was 40%, the specificity 90.5% and the positive predictive value 12.8% to detect relapse of disease during the follow-up of TGCTs. When the series of 116 relapsed patients from 1992 to 2005 was analysed, an increase in LDH facilitated the detection of relapse in 2% of non-seminomatous GCTs and 11% of seminomas, independent of other markers. CONCLUSION:LDH has limited sensitivity, specificity and positive predictive value for detecting relapse of TGCT and false-positive increases are common. An elevated LDH level contributed to the detection in six of 15 relapses, suggesting that its value in the follow-up of TGCT might be useful if interpreted cautiously. High LDH levels during the follow-up might require repeat serial LDH estimates to confirm the elevation, and imaging to detect a relapse.
journal_name
BJU Intjournal_title
BJU internationalauthors
Venkitaraman R,Johnson B,Huddart RA,Parker CC,Horwich A,Dearnaley DPdoi
10.1111/j.1464-410X.2007.06905.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
30-2issue
1eissn
1464-4096issn
1464-410Xpii
BJU6905journal_volume
100pub_type
杂志文章abstract:OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2009.08196.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine whether the density of CD4(+) and CD8(+) T-lymphocytes in a transrectal ultrasonography (TRUS) biopsy of the prostate can be used to predict the progression of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:In total, 100 patients were randomly sel...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09787.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To examine the utility of cyanoacrylate tissue adhesive (Dermabond, Ethicon, Somerville, NJ, USA; an effective means of epithelial skin closure) under a diaper (i.e. constantly exposed to bodily fluids) in 25 children (not toilet-trained) undergoing inguinal surgery. PATIENTS AND METHODS:A retrospective revi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02142.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To examine national trends in the medical and surgical treatment of benign prostatic hyperplasia (BPH) using Australian Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) population data from 2000 to 2018. PATIENTS AND METHODS:Annual data was extracted from the MBS, PBS and Australian ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15098
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:ERG-gene rearrangement defines a distinct molecular subtype of PCA with potential biological and clinical implications. To identify a molecular signature reflective of the downstream effects of ERG-mediated transcriptional regulation with prognostic implication in patients with prostate cancer (PCA). MATERI...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12262
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To describe the pattern and prevalence of lower urinary tract symptoms (LUTS) and related help-seeking behaviour in men of South Asian origin living in the UK, and to compare this to the white population. SUBJECTS AND METHODS:Data were obtained as part of the Leicestershire MRC Incontinence Study. Community-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06377.x
更新日期:2006-09-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Percutaneous renal cryoablation is a safe and effective treatment for patients with small renal masses, who are poor surgical candidates. Oncological outcomes from previous percutaneous ablation studies are difficult to interpret because of the large ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11230.x
更新日期:2012-12-01 00:00:00
abstract::Data from the Japanese Urological Society showed that, in Japan, almost half of patients with localized prostate cancer are treated with hormone therapy (HT), regardless of disease stage, and that radiation therapy (RT) is also widely used to treat high-risk patients. A retrospective study was undertaken in Japan to e...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.06592.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To describe patient selection for sacral neuromodulation, also known as Interstim therapy, and the results of tined-lead implantation in the medium term. PATIENTS AND METHODS:In all, 49 patients, 39 with refractory overactive bladder symptoms and 10 with urinary retention, were implanted with the tined lead ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06508.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect on quality of life of being discharged home with a catheter before definitive treatment in patients with acute urinary retention (AUR). PATIENTS AND METHODS:Patients attending the emergency department with AUR were assessed and discharged home with a catheter if they fulfilled predeter...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00666.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To report several samples of invasive human prostate cancer showing angiotropism, and to use human prostate cancer cells stably expressing green fluorescence protein (GFP) in in vitro and in vivo models to assess the dissemination pathway of prostate cancer cells. MATERIALS AND METHODS:Malignant melanoma an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05474.x
更新日期:2005-05-01 00:00:00
abstract::A detailed history, physical examination, symptom and quality-of-life assessment, and urine analysis are unanimously considered essential components of the initial evaluation of urinary incontinence. Beyond these assessments, there are no universally accepted recommendations and, to date, imaging is not recommended in...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2005.05433.x
更新日期:2005-04-01 00:00:00
abstract:STUDY TYPE:Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data. PATIENTS AND METHODS:This retrospective study included 34 patients treated between October 1997 and October 2007 (...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08813.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To investigate the predictive value (PV) for all prostate cancers and for clinically significant cancer undiagnosed after a 10-core biopsy protocol, as the 10-core transrectal ultrasonography-guided biopsy is considered the standard technique of prostatic biopsy due to its high rate of detection of prostatic ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06453.x
更新日期:2006-11-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? There have been few studies evaluating the prognostic value of epithelial-mesenchymal transition markers in renal cell carcinoma (RCC); therefore, the significance of these markers in the prognosis of patients with RCC, particularly that in those with...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11297.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To determine the influence of radiotherapy on the outcome of artificial urinary sphincter implantation. PATIENTS AND METHODS:A series of 72 men who had an artificial urinary sphincter inserted were reviewed retrospectively, analysing in detail the information from 15 patients with a past history of pelvic ra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To assess the long-term effectiveness of the UroLume trade mark wallstent (Pfizer Inc., UK) in the treatment of detrusor external sphincter dyssynergia (DESD) in quadriplegic patients. PATIENTS AND METHODS:Twelve patients with quadriplegia secondary to spinal trauma underwent external striated sphincter sten...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04009.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (SEPs) after electrical stimulation of different locations in the lower urinary tract (LUT) in a cohort of middle-aged healthy women. SUBJECTS AND METHODS:In a group of 10 healthy middle-aged women [mean (sd...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13066
更新日期:2015-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02666.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.13474
更新日期:2016-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09144.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of patient age with pathological and long-term oncological outcomes after radical cystectomy (RC) for bladder carcinoma, as this disease, like many others, increases in incidence with age. PATIENTS AND METHODS:We retrospectively reviewed 241 consecutive patients with invasive blad...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08033.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS:Men enrolled in the IMP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14412
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of preoperatively measured cardiorespiratory function, to the development of postoperative complications and length of hospital stay (LOS) in a cohort of patients undergoing radical cystectomy (RC), as RC and conduit formation is curative but is associated with significant postop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12219
更新日期:2013-07-01 00:00:00
abstract::OBJECTIVE To describe the rationale and design of the Bladder Cancer Prognosis Programme (BCPP), and to demonstrate the capability of this design. METHODS There is a need to understand the determinants of bladder cancer to help reduce recurrence, progression, morbidity, mortality and related costs. We previously showe...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08849.x
更新日期:2010-03-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? L-dopa decarboxylase (DDC) has been documented as a novel co-activator of androgen receptor transcriptional activity. Recently, it was shown that DDC gene expression is significantly higher in patients with PCa than in those with BPH. In the present s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11152.x
更新日期:2012-09-01 00:00:00
abstract:UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10778.x
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and treatment of lymphoceles after retropubic radical prostatectomy (RP). PATIENTS AND METHODS:Up to January 2004, 260 patients who had a retropubic RP in one institution by one surgeon were assessed retrospectively, using the patients' notes or the computerized results system to d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05398.x
更新日期:2005-04-01 00:00:00