Abstract:
UNLABELLED:What's known on the subject? and What does the study add? There have been few studies evaluating the prognostic value of epithelial-mesenchymal transition markers in renal cell carcinoma (RCC); therefore, the significance of these markers in the prognosis of patients with RCC, particularly that in those with localized disease, remains largely unknown. Consideration of the expression levels of potential epithelial-mesenchymal transition markers, particularly clusterin and Twist in addition to conventional prognostic parameters, would contribute to the prediction of disease recurrence after radical nephrectomy for localized renal cell carcinoma. OBJECTIVE:• To evaluate the expression of multiple molecular markers involved in the process of epithelial-mesenchymal transition (EMT) in renal cell carcinoma (RCC) with the aim of clarifying the prognostic significance of these markers in patients undergoing radical nephrectomy. PATIENTS AND METHODS:• The expression levels of 11 EMT markers, including E-cadherin, N-cadherin, β-catenin, γ-catenin, clusterin, Slug, Snail, Twist, vimentin, ZEB1 and ZEB2, in radical nephrectomy specimens from 122 patients with clinically localized RCC were measured by immunohistochemical staining. RESULTS:• In this series, disease recurrence occurred in 39 (32.0%) patients, with a 5-year recurrence-free survival rate of 64.4%. • Univariate analysis identified expression levels of E-cadherin, clusterin, Twist and vimentin, in addition to C-reactive protein (CRP) level, pathological stage and microvascular invasion, as significant predictors for disease recurrence. • Of these, expression levels of clusterin and Twist, CRP levels and microvascular invasion appeared to be independently related to disease recurrence on multivariate analysis. • There were significant differences in recurrence-free survival according to positive numbers of these four independent factors: disease recurrence occurred in two of 26 patients negative for any risk factor (7.7%), 23 of 73 patients positive for one or two risk factors (31.5%) and 14 of 23 patients positive for three or four risk factors (60.9%). CONCLUSION:• Consideration of the expression levels of potential EMT markers, particularly clusterin and Twist, in RCC specimens, in addition to conventional prognostic parameters, contributes to the accurate prediction of disease recurrence after radical nephrectomy for localized RCC.
journal_name
BJU Intjournal_title
BJU internationalauthors
Harada K,Miyake H,Kusuda Y,Fujisawa Mdoi
10.1111/j.1464-410X.2012.11297.xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
E1131-7issue
11 Pt Ceissn
1464-4096issn
1464-410Xjournal_volume
110pub_type
杂志文章abstract:OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer t...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2010.09273.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of depression, anxiety and distress among active surveillance (AS) and radical prostatectomy (RP) patients. To evaluate the impact of these symptoms at baseline on urinary and sexual quality of life at follow-up. PATIENTS AND METHODS:Patients managed with AS or RP who completed val...
journal_title:BJU international
pub_type: 杂志文章
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abstract:UNLABELLED:What's known on the subject? and What does the study add? Recent studies have indicated that high mobility group box 1 (HMGB1) is related to the development and progression of human carcinomas. However, further studies were required to confirm the roles played by HMGB1 in clinical prostate cancer treatment. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11277.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To report the incidence, risk factors, and outcomes of subcapsular renal haematoma (SRH) after ureteroscopic lithotripsy (URSL) using holmium:yttrium-aluminum-garnet (Ho:YAG) laser to treat ureteric stones. PATIENTS AND METHODS:Prospective data from 2848 URSLs performed between January 2003 and September 201...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10490.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12333
更新日期:2014-03-01 00:00:00
abstract:UNLABELLED:A comparison of laparoscopic and open donor nephrectomy is presented by authors from the UK. They found that the laparoscopic approach could safely be offered to patients treated in experienced units and after adequate training fo the surgeon, with no increase in complications or decrease in efficacy. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05264.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To assess the perioperative complications and early oncological results in a comparative study matching open radical retropubic (RRP) and robot-assisted radical prostatectomy (RARP) groups. PATIENTS AND METHODS:From August 2002 to December 2005 we identified 294 patients undergoing RARP for clinically locali...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08012.x
更新日期:2009-02-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? To date, there has been limited impetus to examine the use of cytarabine in prostate cancer. We presented preliminary laboratory data to suggest its utility in the castration refractory prostate cancer (CRPC) population which, combined with a previous...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10922.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To determine the value of measuring serum concentrations of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with benign prostatic hyperplasia (BPH), advanced and localized prostate cancer, and thus assess the role of angiogenesis factors as markers of malignancy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00363.x
更新日期:1999-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04429.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the therapeutic potential of sympatholytic agents on premature ejaculation in an animal model, using monitoring of rat seminal vesicle pressure change in response to electrical stimulation of the lesser splanchnic nerve. MATERIALS AND METHODS:Male Wistar rats (aged 12-14 weeks) were injected intr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00173.x
更新日期:1999-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13965
更新日期:2018-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2006.06208.x
更新日期:2006-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09211.x
更新日期:2010-11-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The various phenotypes of hypospadias may result from disturbances of dissimilar embryonic processes in different time windows, suggesting aetiological heterogeneity; however, only a few studies have investigated the risk factors for the different hy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11745.x
更新日期:2013-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02809.x
更新日期:2002-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06211.x
更新日期:2006-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
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更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04533.x
更新日期:2003-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00506.x
更新日期:2000-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05115.x
更新日期:2004-11-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Selective destruction of targeted prostate tissue is now technically feasible. Much has been theorized but little is known about the proper patient selection or treatment outcomes to determine if this...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10578.x
更新日期:2012-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00254.x
更新日期:1999-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00933.x
更新日期:1999-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00966.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether ageing and diabetes alter the expression of the gap junction protein connexin43 (Cx43) and of particular purinoceptor (P2R) subtypes in the corpus cavernosum and urinary bladder, and determine whether changes in expression of these proteins correlate with development of erectile and bla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08337.x
更新日期:2009-06-01 00:00:00
abstract:STUDY TYPE:Therapy (case series) Level of Evidence 4. OBJECTIVE:To report our analysis of the oncological outcome, side-effects and complications after (125)I-brachytherapy, based on 10 years of experience, as low dose-rate (LDR) prostate brachytherapy is an accepted, effective and safe therapy for localized prostate ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09096.x
更新日期:2010-07-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00