Abstract:
OBJECTIVE:To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens. MATERIALS AND METHODS:Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overexpressed in prostate cancer (p504s), on 63 small prostate cancer foci (<1 mm) and 109 cases of ambiguous lesions observed in needle biopsies. RESULTS:After p63/p504s immunostaining, 93% of the ambiguous lesions (102/109) were classified. The final diagnoses retained were: 92 prostate cancers, seven atypical small acinar proliferations suspected of being malignant but undiagnosed, 21 prostatic intraepithelial neoplasia, five atypical adenomatous hyperplasia, and 36 atrophic benign mimickers of cancer. CONCLUSIONS:Combining p504s as a positive marker for prostate cancer and p63 as a negative marker might improve diagnostic performance, sensitivity and specificity, and lead to fewer false-negative results. This simple immunostaining procedure should reduce the percentage of residual ambiguous lesions and the need for additional biopsies.
journal_name
BJU Intjournal_title
BJU internationalauthors
Molinié V,Hervé JM,Lugagne PM,Lebret T,Botto Hdoi
10.1111/j.1464-410X.2006.06069.xsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
1109-15issue
5eissn
1464-4096issn
1464-410Xpii
BJU6069journal_volume
97pub_type
杂志文章abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: There are two randomized controlled trials showing that radiotherapy can be beneficial for men with locally advanced prostate cancer. The present study confirms the importance of curative treatment for men with high-risk prostate cancer. OBJECTIVE:T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11320.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08984.x
更新日期:2010-05-01 00:00:00
abstract:UNLABELLED:Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The present study was to perform contrast-tuned imaging (CnTI) technology to detect prostate cancer and compare the use of CnTI technology for the detection of prostate cancer with conv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10577.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:To investigate the long-term outcomes of laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:In all, 1138 patients underwent LRP during a 163-month period from 2000 to 2008, of which 51.5%, 30.3% and 18.2% were categorised into D'Amico risk groups of low-, intermediate- and high-risk, respectivel...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12887
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). PATIENTS AND METHODS:We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between Janu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12329
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To determine if the biochemical composition of a renal calculus can be measured from 'dust' obtained during laser fragmentation. PATIENTS AND METHODS:This pilot study was set in a tertiary referral hospital between 2011 and 2013. Stone dust was aspirated through the ureteroscope during lasering and a stone f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13448
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of asymptomatic bacteriuria (ABU) and urinary tract infection (UTI), and the local and systemic inflammatory response, in patients with ileal neobladder. PATIENTS AND METHODS:The study included 40 patients who had a radical cystectomy and ileal neobladder. Two urine samples, one...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07366.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of prostate weight on perioperative, functional and oncological outcomes after laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:Between January 2003 and January 2006, 327 patients had LRP by one surgeon, 193 of whom were available for analysis. Patients were stratified in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07263.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00979.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the early results of hand-assisted radical nephrectomy and nephroureterectomy in our institution. PATIENTS AND METHODS:The records of 13 patients with malignant disease of the kidney who underwent hand-assisted laparoscopic radical nephrectomy and nephroureterectomy were reviewed retrospectively....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02955.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10315.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To study the recovery of testosterone levels and erectile function in men who received radiotherapy plus long-term adjuvant androgen deprivation (LTAD) with luteinizing hormone-releasing hormone (LHRH) agonists. PATIENTS AND METHODS:From April 2000 to July 2001, men who had completed prostate radiotherapy wi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06066.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To report our experience with the use of 95% ethanol as sclerotherapy for symptomatic simple renal cysts. PATIENTS AND METHODS:Sixty patients with 64 symptomatic simple renal cysts were treated by ultrasonography (US)-guided percutaneous aspiration and injection of 95% ethanol (31 men and 29 women, mean age ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05851.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of detrusor instability (DI) detected by conventional and ambulatory bladder pressure monitoring, any link between urodynamic findings before and after colposuspension, and between patients' symptoms and the urodynamic findings. PATIENTS AND METHODS:Sixty-five patients, scheduled t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00390.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To evaluate whether injection with pericapsular lignocaine before transrectal ultrasonography (TRUS)-guided biopsy reduces the perceived pain of prostatic biopsy. PATIENTS AND METHODS:The study included 121 patients referred for TRUS-guided biopsy of the prostate; 27 underwent biopsy with no previous injecti...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of using a ganglial culture system to screen various growth factors as potential therapeutic agents for pelvic nerve injuries. MATERIALS AND METHODS:The major pelvic ganglia (MPG) were isolated from male rats and attached to culture dishes with the aid of Matrigel (Becton Dicki...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04439.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To characterize the clinical outcomes of androgen deprivation therapy (ADT) as the sole therapy for localized prostate cancer, and to determine independent predictors of disease progression, as recent studies indicate an increasing use of ADT. PATIENTS AND METHODS:The records of all patients with cT1-4NXM0 a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05674.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:• To assess the feasibility of radical prostatectomy (RP) in a series of patients with prostate cancer with very high prostate-specific antigen (PSA) levels by comparing the clinical outcomes of different PSA thresholds (20.1-50 ng/mL, 50.1-100 ng/mL and >100 ng/mL, respectively). PATIENTS AND METHODS:• With...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10076.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To explore the expression of transforming growth factor-beta(1) (TGF-beta1) in penile tissue from rats after bilateral cavernosal nerve (CN) ablation, mimicking patients who have had no nerve-sparing during prostatectomy. MATERIALS AND METHODS:Ten adult male rats (neurectomy group) had a bilateral CN resecti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04969.x
更新日期:2004-08-01 00:00:00
abstract::• To review the published data on predisposing risk factors for cancer treatment-induced haemorrhagic cystitis (HC) and the evidence for the different preventive and therapeutic measures that have been used in order to help clinicians optimally define and manage this potentially serious condition. • Despite recognitio...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12291
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04237.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To examine the effects of mirabegron, a selective β3 -adrenoceptor agonist that has recently been approved for the treatment of overactive bladder (OAB), on erectile function. Stimulation of β3 -adrenoceptors localised in cavernosal smooth muscle cells may play a physiological role in mediating penile erectio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13515
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02033.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:To compare the prevalence of metabolic syndrome and the components of metabolic syndrome in men aged ≥50 years with and without clinical benign prostatic hyperplasia (BPH). SUBJECTS AND METHODS:This was a cross-sectional study using the UK Clinical Practice Research Datalink (CPRD). Men were selected from t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13334
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To investigate the frequency and spectrum of lipophilic Malassezia yeasts within the area of the glans penis and preputial space in healthy men, most of whom were uncircumcised. SUBJECTS AND METHODS:As the glans penis and the prepuce are abundant in sebaceous glands, 130 clinically healthy men were examined ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02375.x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To report our 5-year experience with laparoscopic and percutaneous cryoablation (LCA and PCA) for managing small renal masses. PATIENTS AND METHODS:We retrospectively analysed patients undergoing LCA and PCA between October 2000 and March 2006 at our institution. After approval from the Institutional Review ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07158.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12549
更新日期:2014-12-01 00:00:00
abstract::OBJECTIVE To describe the rationale and design of the Bladder Cancer Prognosis Programme (BCPP), and to demonstrate the capability of this design. METHODS There is a need to understand the determinants of bladder cancer to help reduce recurrence, progression, morbidity, mortality and related costs. We previously showe...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08849.x
更新日期:2010-03-01 00:00:00