Increased expression of transient receptor potential vanilloid subfamily 1 in the bladder predicts the response to intravesical instillations of resiniferatoxin in patients with refractory idiopathic detrusor overactivity.

Abstract:

OBJECTIVES:To investigate the correlation of transient receptor potential vanilloid subfamily 1 (TRPV1) mRNA expression levels and the clinical outcome of intravesical resiniferatoxin treatment in patients with idiopathic detrusor overactivity (IDO), as such treatment with vanilloids can be effective for DO. PATIENTS AND METHODS:In all, 28 patients with IDO refractory to anticholinergics were enrolled and treated with four weekly intravesical instillations of 10 nm resiniferatoxin. Eleven patients having ureteroscopic surgery served as controls. Two bladder wall biopsies were taken from the posterior wall by rigid cystoscopy. TRPV1 expression in the bladder wall samples was determined by individual quantitative reverse transcription-polymerase chain reaction, and immunohistochemical staining. Responders to the therapy were defined as those with an improvement in an urgency scale by >/=1, and with improved general satisfaction. Baseline TRPV1 expression was compared between responders, nonresponders and controls. RESULTS:At 3 months, 14 patients (50%) were responders and in the other 14 the treatment failed (nonresponders). Bladder biopsies were available in seven responders and 11 nonresponders. Transcript levels before treatment correlated significantly with the therapeutic effect of resiniferatoxin (P = 0.004), with higher TRPV1 mRNA expression in responders (median 1.50, range 0.89-2.78) than nonresponders (0.74, 0.34-1.32). Responders also had higher TRPV1 expression levels than a control group (P = 0.067), but the TRPV1 transcript levels of nonresponders were not significantly different from those of the control (P = 0.367). CONCLUSION:Successful intravesical resiniferatoxin treatment is closely associated with the over-expression of TRPV1 in the bladder mucosa and submucosa in patients with IDO.

journal_name

BJU Int

journal_title

BJU international

authors

Liu HT,Kuo HC

doi

10.1111/j.1464-410X.2007.07151.x

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1086-90

issue

5

eissn

1464-4096

issn

1464-410X

pii

BJU7151

journal_volume

100

pub_type

杂志文章
  • USANZ: Time-trends in use and impact on outcomes of perioperative chemotherapy in patients treated with radical cystectomy for urothelial bladder cancer.

    abstract:OBJECTIVE:To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. PATIENTS AND METHODS:Using electronic and paper medical records, 89 patients were identified who underwent radical cystectomy...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12384

    authors: Liew MS,Azad A,Tafreshi A,Eapen R,Bolton D,Davis ID,Sengupta S

    更新日期:2013-11-01 00:00:00

  • Sexual function before and after various treatments for symptomatic benign prostatic hyperplasia.

    abstract:OBJECTIVE:To determine the effect of various treatments for benign prostatic hyperplasia (BPH) on sexual function. PATIENTS AND METHODS:In a longitudinal multicentre study carried out in the Netherlands, 670 consecutive patients with BPH (aged > or = 50 years) were examined at baseline and 9 months after inclusion. Al...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-4096.2001.01817.x

    authors: Leliefeld HH,Stoevelaar HJ,McDonnell J

    更新日期:2002-02-01 00:00:00

  • The 'modified prone position': a new approach for treating pre-vesical stones with extracorporeal shock wave lithotripsy.

    abstract:OBJECTIVE:To investigate the utility of a new 'modified-prone' position for treating pre-vesical stones with extracorporeal shock wave lithotripsy (ESWL), usually considered an acceptable and effective treatment for such stones, but for which many different body positions have been used in an attempt to increase its ef...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410x.2003.04619.x

    authors: Köse AC,Demirbas M

    更新日期:2004-02-01 00:00:00

  • A double-blind randomized controlled trial and economic evaluation of transurethral resection vs contact laser vaporization for benign prostatic enlargement: a 3-year follow-up.

    abstract:OBJECTIVE:To evaluate the effect of contact laser prostate surgery in the treatment of benign prostatic hyperplasia. PATIENTS AND METHODS:A prospective double-blind randomized controlled trial of transurethral resection of the prostate (TURP) and contact laser prostatectomy was conducted, with an economic evaluation o...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00407.x

    authors: Keoghane SR,Lawrence KC,Gray AM,Doll HA,Hancock AM,Turner K,Sullivan ME,Dyar O,Cranston D

    更新日期:2000-01-01 00:00:00

  • Clinical trial risk in castration-resistant prostate cancer: immunotherapies show promise.

    abstract:OBJECTIVES:To determine the risk of failure during drug development in castration-resistant prostate cancer (CRPC) and to identify factors that could improve outcomes. METHODS:We investigated CRPC by analysing compounds in phase I to phase III clinical trials between 1998 and April 2011. Drug development failures were...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12309

    authors: Tenuta A,Klotz L,Parker JL

    更新日期:2014-05-01 00:00:00

  • A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.

    abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2010.09801.x

    authors: Ye Z,Yang H,Li H,Zhang X,Deng Y,Zeng G,Chen L,Cheng Y,Yang J,Mi Q,Zhang Y,Chen Z,Guo H,He W,Chen Z

    更新日期:2011-07-01 00:00:00

  • Novel methods for the diagnosis and treatment of ejaculatory duct obstruction.

    abstract:OBJECTIVES:• To investigate a new method of vas deferens radiography for ejaculatory duct obstruction (EDO). • To evaluate the effect of a procedure involving dilation of the ejaculatory duct by F9 seminal vesicoscopy. PATIENTS AND METHODS:• Twenty-two patients with EDO were diagnosed using semen analysis, semen fruct...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09775.x

    authors: Xu B,Niu X,Wang Z,Li P,Qin C,Li J,Liu B,Wang P,Jia Y,Wu H,Zhang W

    更新日期:2011-07-01 00:00:00

  • Patients with prostate cancer continue to have excess mortality up to 15 years after diagnosis.

    abstract:OBJECTIVE:To estimate the population-based conditional 5-year relative survival rates for patients with prostate cancer (PCa). PATIENTS AND METHODS:All 98 672 patients, aged 45-89 years, diagnosed in the Netherlands with PCa (clinical T stage 1-4) in the period 1989-2008 were selected from the Netherlands Cancer Regis...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12519

    authors: Husson O,van Steenbergen LN,Koldewijn EL,Poortmans PM,Coebergh JW,Janssen-Heijnen ML

    更新日期:2014-11-01 00:00:00

  • Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine.

    abstract:OBJECTIVES:To assess the utility of perceived control over ejaculation ('control') in the evaluation of treatment benefit in men with premature ejaculation (PE), and to compare effects associated with a two-category or greater increase in this variable between men receiving dapoxetine and placebo. PATIENTS AND METHODS...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2008.07845.x

    authors: Shabsigh R,Patrick DL,Rowland DL,Bull SA,Tesfaye F,Rothman M

    更新日期:2008-09-01 00:00:00

  • The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats.

    abstract:OBJECTIVE:• To investigate the role of c-kit-positive interstitial cells (ICCs) in mediating muscarinic receptor-induced phasic contractions of isolated bladder strips from streptozotocin(STZ)-induced diabetic rats and to confirm the expression and location of ICCs in the rat bladder. MATERIALS AND METHODS:• Bladders ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09507.x

    authors: Vahabi B,McKay NG,Lawson K,Sellers DJ

    更新日期:2011-05-01 00:00:00

  • Retroperitoneal laparoscopic vs open partial nephroureterectomy in children.

    abstract:OBJECTIVES:To compare the results of retroperitoneal laparoscopic with open partial nephroureterectomy. PATIENTS AND METHODS:Laparoscopic retroperitoneal partial nephroureterectomy was undertaken in 15 children (13 upper and two lower poles; median age at the time of surgery 61 months, range 5-212). A three-trocar ret...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04126.x

    authors: El-Ghoneimi A,Farhat W,Bolduc S,Bagli D,McLorie G,Khoury A

    更新日期:2003-04-01 00:00:00

  • Endoluminal ultrasonography before retrograde endopyelotomy: can the results match laparoscopic pyeloplasty?

    abstract:OBJECTIVE:To present the results of endopyelotomy using endoluminal ultrasonography (EUS) to identify crossing vessels, as the success rates of endopyelotomy are generally lower than pyeloplasty, especially in patients with crossing vessels. PATIENTS AND METHODS:Forty-one consecutive patients who underwent EUS before ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04103.x

    authors: Parkin J,Evans S,Kumar PV,Timoney AG,Keeley FX Jr

    更新日期:2003-03-01 00:00:00

  • The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel.

    abstract:OBJECTIVE:To establish a consensus on the utility of multiparametric magnetic resonance imaging (mpMRI) to identify patients for focal therapy. METHODS:Urological surgeons, radiologists, and basic researchers, from Europe and North America participated in a consensus meeting about the use of mpMRI in focal therapy of ...

    journal_title:BJU international

    pub_type: 共识发展会议,杂志文章

    doi:10.1111/bju.12243

    authors: Muller BG,Fütterer JJ,Gupta RT,Katz A,Kirkham A,Kurhanewicz J,Moul JW,Pinto PA,Rastinehad AR,Robertson C,de la Rosette J,Sanchez-Salas R,Jones JS,Ukimura O,Verma S,Wijkstra H,Marberger M

    更新日期:2014-02-01 00:00:00

  • Frozen section during partial nephrectomy: does it predict positive margins?

    abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13011

    authors: Gordetsky J,Gorin MA,Canner J,Ball MW,Pierorazio PM,Allaf ME,Epstein JI

    更新日期:2015-12-01 00:00:00

  • MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.

    abstract:OBJECTIVE:To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model. MATERIALS AND METHODS:Sprague-Dawley rats of both sexes were divided into five groups of 10 each, with group 1...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06274.x

    authors: Rajasekaran M,Locke KW,Parsons CL

    更新日期:2006-08-01 00:00:00

  • Consensus statements on the management of metastatic prostate cancer from the Hong Kong Urological Association and Hong Kong Society of Uro-Oncology.

    abstract::To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPCa) in Hong Kong. A local expert consensus was organized jointly by the two main professional organizations representing prostate cancer specialists in Hong Kong. A total of 12 exper...

    journal_title:BJU international

    pub_type: 共识发展会议,杂志文章

    doi:10.1111/bju.14091

    authors: Poon DM,Chan CK,Chan TW,Cheung FY,Kwong PW,Lee EK,Leung AK,Leung SY,Ma WK,So HS,Tam PC,Ho LY

    更新日期:2018-05-01 00:00:00

  • An update on experience with the single-instrument port laparoscopic nephrectomy.

    abstract:OBJECTIVE:To describe a modification of the posterior prone retroperitoneoscopic nephrectomy, which allows the entire operation to be performed through a single instrument port. PATIENTS AND METHODS:With the patient prone, a retroperitoneal working space is created using a custom-made balloon lateral to the sacrospina...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08232.x

    authors: Msezane LP,Mushtaq I,Gundeti MS

    更新日期:2009-05-01 00:00:00

  • The pitfalls of vaginal construction.

    abstract:OBJECTIVE:To evaluate a group of young women undergoing complex vaginoplasty, which may be defined as where there has already been previous complex pelvic surgery and the patient is unsuitable for conservative treatment or minor surgical revision. PATIENTS AND METHODS:All patients who had undergone a complex vaginopla...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05522.x

    authors: Davies MC,Creighton SM,Woodhouse CR

    更新日期:2005-06-01 00:00:00

  • Cyclooxygenase-2 (COX-2) inhibition for prostate cancer chemoprevention: double-blind randomised study of pre-prostatectomy celecoxib or placebo.

    abstract:OBJECTIVE:To evaluate the biological effects of selective cyclooxygenase-2 inhibition on prostate tissue in patients undergoing radical prostatectomy (RP). PATIENTS AND METHODS:Patients with localised prostate cancer were randomised to receive either celecoxib 400 mg twice daily or placebo for 4 weeks before RP. Speci...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bju.13612

    authors: Flamiatos JF,Beer TM,Graff JN,Eilers KM,Tian W,Sekhon HS,Garzotto M

    更新日期:2017-05-01 00:00:00

  • Assessing the anatomical characteristics of renal masses has a limited effect on the prediction of pathological outcomes in solid, enhancing, small renal masses: results using the PADUA classification system.

    abstract:OBJECTIVE:To evaluate whether assessing the anatomical characteristics of renal masses increases the accuracy of prediction of tumour pathology in small renal masses (SRMs). PATIENTS AND METHODS:We retrospectively reviewed 1129 consecutive patients who underwent extirpative surgeries for a clinical T1 renal mass, for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12446

    authors: Shin TY,Kim J,Koo KC,Lim SK,Kim DW,Kang MW,Rha KH,Choi YD,Ham WS

    更新日期:2014-05-01 00:00:00

  • Population-based trends in urinary diversion among patients undergoing radical cystectomy for bladder cancer.

    abstract:UNLABELLED:What's known on the subject? and what does the study add?: Variations in the type of urinary diversion exist for patients undergoing radical cystectomy. Although its use has been increasing from 2001 to 2008, patients who are older, female, and primary insured by Medicaid are less likely to receive continent...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11508.x

    authors: Kim SP,Shah ND,Weight CJ,Thompson RH,Wang JK,Karnes RJ,Han LC,Ziegenfuss JY,Frank I,Tollefson MK,Boorjian SA

    更新日期:2013-08-01 00:00:00

  • Is there a prostate-specific antigen upper limit for radical prostatectomy?

    abstract:OBJECTIVE:• To assess the feasibility of radical prostatectomy (RP) in a series of patients with prostate cancer with very high prostate-specific antigen (PSA) levels by comparing the clinical outcomes of different PSA thresholds (20.1-50 ng/mL, 50.1-100 ng/mL and >100 ng/mL, respectively). PATIENTS AND METHODS:• With...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10076.x

    authors: Gontero P,Spahn M,Tombal B,Bader P,Hsu CY,Marchioro G,Frea B,Van Der Eeckt K,Kneitz B,Frohneberg D,Tizzani A,Van Poppel H,Joniau S

    更新日期:2011-10-01 00:00:00

  • Chemo-prevention in superficial bladder cancer using mitomycin C: a survey of the practice patterns of British urologists.

    abstract:OBJECTIVE:To assess the use of mitomycin C, by urologists within the UK, as a single-dose intravesical agent. Current European recommendations are to use one dose after any new tumour resection. METHODS:We assessed the current patterns of mitomycin C usage amongst British urologists, particularly with reference to one...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.05970.x

    authors: Clarke NS,Basu S,Prescott S,Puri R

    更新日期:2006-04-01 00:00:00

  • Risk factors for different phenotypes of hypospadias: results from a Dutch case-control study.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The various phenotypes of hypospadias may result from disturbances of dissimilar embryonic processes in different time windows, suggesting aetiological heterogeneity; however, only a few studies have investigated the risk factors for the different hy...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11745.x

    authors: van Rooij IA,van der Zanden LF,Brouwers MM,Knoers NV,Feitz WF,Roeleveld N

    更新日期:2013-07-01 00:00:00

  • Direct comparison of radiology and nuclear medicine cystograms in young infants with vesico-ureteric reflux.

    abstract:OBJECTIVE:To determine the sensitivity of the direct radionuclide cystogram (DRC) in detecting vesico-ureteric reflux compared with the micturating cysto-urethrogram (MCU) in the same initial setting, in infants younger than one year. PATIENTS AND METHODS:The results from the dual cystograms of 62 refluxing infants < ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.00997.x

    authors: McLaren CJ,Simpson ET

    更新日期:2001-01-01 00:00:00

  • Experience with demucosalized ileum for bladder augmentation.

    abstract:OBJECTIVE:To assess the use of demucosalized ileum for bladder augmentation, following the same principles previously used with the sigmoid colon. PATIENTS AND METHODS:Eleven patients with bladder exstrophy or a neurogenic bladder had their bladders augmented with demucosalized ileum instead of the sigmoid colon, but ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-4096.2001.lima.2465.x

    authors: Lima SV,Araújo LA,Vilar FO,Mota D,Maciel A

    更新日期:2001-11-01 00:00:00

  • Optimizing prostate cancer detection during biopsy by standardizing the amount of tissue examined per core.

    abstract:OBJECTIVE:To investigate the effect on cancer detection by varying the number of cores taken for prostate biopsy according to the size of the prostate. PATIENTS AND METHODS:A retrospective review of a prospectively registered prostate biopsy database identified 3040 consecutive patients undergoing prostate biopsy at a...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10239.x

    authors: Sfakianos JP,Thorner DA,Dovirak O,Weiss JP,Karanikolas NT

    更新日期:2011-11-01 00:00:00

  • Totally intracorporeal robot-assisted radical cystectomy: optimizing total outcomes.

    abstract::We performed a systematic literature review to assess the current status of a totally intracorporeal robot-assisted radical cystectomy (RARC) approach. The current 'gold standard' for radical cystectomy remains open radical cystectomy. RARC has lagged behind robot-assisted prostatectomy in terms of adoption and percei...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.12558

    authors: Collins JW,Wiklund NP

    更新日期:2014-09-01 00:00:00

  • Suburethral sling at the time of radical prostatectomy in patients at high risk of postoperative incontinence.

    abstract:OBJECTIVE:To evaluate the insertion of a urethral sling at the time of radical prostatectomy (RP) in men at high risk of urinary incontinence after RP. PATIENTS AND METHODS:Between 1998 and 2000, 49 of 871 men undergoing RP at The University of Texas M.D. Anderson Cancer Center, were identified as at risk of urinary i...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06220.x

    authors: Westney OL,Scott S,Wood C,Eddings T,Johnson MM,Taylor JM,McGuire E,Pisters LL

    更新日期:2006-08-01 00:00:00

  • Minimum 5-year follow-up of 1138 consecutive laparoscopic radical prostatectomies.

    abstract:OBJECTIVES:To investigate the long-term outcomes of laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:In all, 1138 patients underwent LRP during a 163-month period from 2000 to 2008, of which 51.5%, 30.3% and 18.2% were categorised into D'Amico risk groups of low-, intermediate- and high-risk, respectivel...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12887

    authors: Soares R,Di Benedetto A,Dovey Z,Bott S,McGregor RG,Eden CG

    更新日期:2015-04-01 00:00:00