Abstract:
OBJECTIVE:To determine whether aneusomy for chromosomes 7, 9 and 17 (reported to predict recurrence in up to 65% of patients with superficial transitional cell bladder cancer and thus providing the opportunity for early and effective treatment) reflects specific genetic events on these chromosomes or merely wider unspecific genetic damage to the cell, e.g. that increased copy numbers for 7 and 17 reflect tumour polyploidy. MATERIALS AND METHODS:The study comprised 25 primary tumours; 6 microm thick sections from formalin-fixed and paraffin-embedded tumours were analysed. Chromosome copy numbers were determined by fluorescence in situ hybridization (FISH) using pericentromeric probes for chromosomes 7, 8, 9, 10, 11 and 17. A minimum of 200 nuclei per tumour area were scored by two independent observers. RESULTS:Eight of the 25 tumours examined (32%) showed no evidence of chromosomal abnormalities as detected by FISH for any chromosomes analysed. Twelve tumours (48%) showed abnormalities for one or two chromosomes, five tumours (20%) showed abnormalities for multiple chromosomes and one tumour showed abnormalities for all chromosomes analysed, suggestive of polyploidy. CONCLUSIONS:Chromosomal abnormalities predictive of recurrence occur largely in the absence of other gross chromosomal lesions. In a small proportion of cases other chromosomes are affected, but this is almost always distinct from tumour polyploidy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Bartlett JM,Adie L,Watters AD,Going JJ,Grigor KMdoi
10.1046/j.1464-410x.1999.00268.xkeywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
775-9issue
7eissn
1464-4096issn
1464-410Xpii
bju268journal_volume
84pub_type
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.07173.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To validate a flexible cystoscopy simulator by determining if it could differentiate between expert and novice cystoscopists. SUBJECTS AND METHODS:Seventeen subjects (10 novices with no previous endoscopic experience and seven urologists who had all carried out > 1000 flexible cystoscopies each) were asked ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03090.x
更新日期:2002-12-01 00:00:00
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更新日期:2012-09-01 00:00:00
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更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06521.x
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pub_type: 临床试验,杂志文章
doi:10.1046/j.1464-410x.2002.02788.x
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journal_title:BJU international
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06681.x
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:BJU international
pub_type: 杂志文章,评审
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更新日期:2007-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04863.x
更新日期:2004-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09775.x
更新日期:2011-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08704.x
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00