Abstract:
OBJECTIVE:To describe the preclinical pharmacology of Ro 115-1240, a peripherally acting selective alpha1A/1L-adrenoceptor (AR) partial agonist, compared with the alpha1A/1L-AR full agonist amidephrine, as AR agonists have some utility in the treatment of stress urinary incontinence (SUI) but are limited by undesirable cardiovascular and central nervous system side-effects. RESULTS:In radioligand-binding studies Ro 115-1240 had greater affinity for alpha1A than for alpha1B and alpha1D subtypes. The potency and intrinsic activity of amidephrine and Ro 115-1240 relative to noradrenaline were determined in native and cell-based assays using human recombinant alpha1-ARs; they acted as selective alpha1A/1L-AR full and partial agonists, respectively. In anaesthetized micropigs and rabbits, amidephrine and Ro 115-1240 produced non-selective, dose-dependent increases in intraurethral and arterial blood pressures but the magnitude of the pressure increases evoked by Ro 115-1240 were about a third of those with amidephrine. In conscious micropigs both agents produced dose-dependent increases in urethral tension. Again, the magnitude of the urethral response to Ro 115-1240 was about a third of that with amidephrine. More importantly, only amidephrine produced dose-dependent increases in blood pressure and decreases in heart rate. Ro 115-1240 produced a maximum increase in urethral tension with no effect on blood pressure or heart rate. CONCLUSION:These results show that by combining selectivity for the alpha1A/1L-AR subtype with a reduction in intrinsic agonist efficacy, Ro 115-1240 has reduced haemodynamic effects while retaining to some degree the contractile effects on urethral smooth muscle. These studies indicate that Ro 115-1240 may be useful as a novel treatment for SUI.
journal_name
BJU Intjournal_title
BJU internationalauthors
Blue DR,Daniels DV,Gever JR,Jett MF,O'Yang C,Tang HM,Williams TJ,Ford APdoi
10.1111/j.1464-410x.2004.04577.xkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
162-70issue
1eissn
1464-4096issn
1464-410Xpii
4577journal_volume
93pub_type
杂志文章abstract:OBJECTIVES:To identify differentially expressed genes between relapsed and non-relapsed clinical stage I testicular germ cell tumours (TGCTs). MATERIALS AND METHODS:We reviewed patients with clinical stage I non-seminoma and seminoma from an institutional database (2000-2012) who were managed by active surveillance. P...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14372
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abstract:OBJECTIVE:To assess the impact of positive surgical margins (PSMs) on long-term outcomes after radical prostatectomy (RP), including metastasis, castrate-resistant prostate cancer (CRPC), and prostate cancer-specific mortality (PCSM). PATIENTS AND METHODS:Retrospective study of 4,051 men in the Shared Equal Access Reg...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13181
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To explore the possibility that allogeneic responses might, by chance, encompass cross-reactive T cell clones specific for neo-antigenic tumour determinants, and thereby activate antitumour immunity; such cross-reactions are well documented for antiviral immunity, and genetic instability in developing cancers...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2006.06421.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS:Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybri...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00654.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07068.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To assess the potential use of bone marrow stromal cell (BMSC)-seeded biodegradable scaffold for bladder regeneration in a canine model, by characterizing BMSCs and comparing them to bladder smooth muscle cells (SMCs) by immunohistochemistry, growth capability, and contractility. MATERIALS AND METHODS:Bone m...
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05741.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To determine patient satisfaction and experience after robot-assisted radical prostatectomy (RARP) for prostate cancer, using a convergent mixed-method qualitative analysis approach. PATIENTS AND METHODS:412 patients who underwent RARP between January 2014 and June 2016 were mailed questionnaires and invited...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14226
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To assess reports supporting the novel and comprehensive evidence-based pathway for radical prostatectomy (RP), as collaborative-care pathways have helped to optimize management of patients treated with RP and such clinical pathways provide an ideal framework for constructing an original evidence-based pathwa...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.06777.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the variability of subjective tutor performance improvement (Pi) assessment and to compare it with a novel measurement algorithm: the Pi score. MATERIALS AND METHODS:The Pi-score algorithm considers time measurement and number of errors from two different repetitions (first and fifth) of the same...
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pub_type: 杂志文章
doi:10.1111/bju.14621
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abstract:OBJECTIVES:To evaluate robotic dry laboratory (dry lab) exercises in terms of their face, content, construct and concurrent validities. To evaluate the applicability of the Global Evaluative Assessment of Robotic Skills (GEARS) tool to assess dry lab performance. MATERIALS AND METHODS:Participants were prospectively c...
journal_title:BJU international
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04749.x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Pelvi-ureteric junction (PUJ) obstruction is characterized by a functionally significant impairment of urinary transport caused by intrinsic or extrinsic obstruction in the area where the ureter joins the renal pelvis. The majority of cases are congenital in origin; however, acquired conditions at the level ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08682.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of solitary rib lesions on pre-treatment 68 Gallium-labelled prostate-specific membrane antigen (PSMA)/computed tomography (CT) scans in men with prostate cancer that are malignant and examine any predictive factors. PATIENTS AND METHODS:This retrospective single tertiary referra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15152
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To determine the most frequent urodynamic observations associated with bladder calculi, and to assess whether the presence of calculi alters these observations. PATIENTS AND METHODS:Fifty patients with bladder stones were included in a prospective study in which two urodynamic tests were used, one at inclus...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04815.x
更新日期:2004-06-01 00:00:00
abstract::Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2008.07496.x
更新日期:2008-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12260
更新日期:2014-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12890
更新日期:2015-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13854
更新日期:2017-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07283.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of demographic, clinical, treatment and patient-reported parameters on satisfaction with prostate cancer care. Despite the significant worldwide impact of prostate cancer, few data are available specifically addressing satisfaction with treatment-related care. PATIENTS AND METHODS:CaPS...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11423.x
更新日期:2013-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To investigate the pharmacology and functionality of alpha(1)-adrenoceptors in human corpus cavernosum, and to determine the predominant subtype. MATERIALS AND METHODS:Cavernosal tissue specimens were obtained from the penises of 22 men (mean age 37.4 years) removed during gender re-assignment surgery. The m...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05956.x
更新日期:2006-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00010.x
更新日期:1999-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13448
更新日期:2016-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...
journal_title:BJU international
pub_type: 杂志文章,meta分析
doi:10.1111/j.1464-410X.2004.05255.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04020.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07474.x
更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07263.x
更新日期:2008-03-01 00:00:00