Abstract:
OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cancers such as prostate cancer. PATIENTS AND METHODS:We performed a retrospective, multi-institutional study involving HIV-positive men with concomitant prostate carcinoma. We collected data regarding patient demographics (age, race), HIV status (CD4(+) cell count, HIV viral load, HAART), PSA level (at cancer diagnosis), symptoms and signs, radiological findings, pathology (Gleason score, stage), cancer treatment (type, side-effects), and outcome (response, survival). Accrued data was analysed using descriptive statistics. RESULTS:We identified 17 patients (mean age 59 years) with HIV-associated prostate adenocarcinoma. The mean CD4(+) count was 336 cells/mm(3) and the mean HIV viral load was 17 319 copies/mL. In all, 14 (82%) of these men were receiving HAART. Most patients were diagnosed with carcinoma after an abnormal screening PSA level. The mean PSA level was 30 ng/mL. Only six (35%) men had an abnormal prostate on examination. The mean Gleason score was 6.8, and in most cases, cancer was confined to the prostate gland. Most patients were amenable to curative treatment with hormonal therapy, radiation, and/or prostatectomy. There were no serious treatment related side-effects. One patient remained untreated. All treated patients had a complete response (undetectable PSA level). Most patients were long-term survivors. Documented death in five cases was unrelated to prostate cancer. CONCLUSION:The management of HIV-positive men with prostate carcinoma in the HAART era is becoming increasingly important. Our data shows that in men receiving HAART, their age, PSA levels, clinical presentation, management, and outcome from treated prostate carcinoma does not appear to be significantly altered by HIV status. Therefore, we recommend that patients with prostate cancer and well-controlled HIV viraemia be managed similarly to their HIV-negative counterparts.
journal_name
BJU Intjournal_title
BJU internationalauthors
Pantanowitz L,Bohac G,Cooley TP,Aboulafia D,Dezube BJdoi
10.1111/j.1464-410X.2008.07474.xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
1519-23issue
12eissn
1464-4096issn
1464-410Xpii
BJU7474journal_volume
101pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To investigate the frequency and spectrum of lipophilic Malassezia yeasts within the area of the glans penis and preputial space in healthy men, most of whom were uncircumcised. SUBJECTS AND METHODS:As the glans penis and the prepuce are abundant in sebaceous glands, 130 clinically healthy men were examined ...
journal_title:BJU international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BJU international
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09704.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09808.x
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07263.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13043
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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更新日期:2012-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2003.04609.x
更新日期:2004-02-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00416.x
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06209.x
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pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
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更新日期:2013-03-01 00:00:00
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更新日期:2010-02-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05054.x
更新日期:2004-10-01 00:00:00
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更新日期:2006-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00