当前位置： SCI文献检索 > BJU INTERNATIONAL期刊下所有文献 > Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer.

Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer.

Abstract：

OBJECTIVE:To assess the extent to which prostate HistoScanning (PHS), a new ultrasound-based technology that uses computer-aided analysis to quantify tissue disorganization induced by malignant processes, can identify and characterize foci of prostate cancer compared with step-sectioned radical prostatectomy (RP) specimens. PATIENTS AND METHODS:Between September 2004 and February 2006, 29 men had PHS before their scheduled RP. A three-dimensional ultrasound raw-data file was acquired, and PHS analysed regions of interest (ROI) corresponding to tissue volumes of approximately 0.04 mL. In 13 men the histology was examined on sections of the whole-mount prostate onto which a grid of 5 x 5 mm squares was applied. On a test set of 14 of the 29 patients, PHS analysis was used before knowing the histology results (blinded data), to predict the maximum tumour diameter, focality, laterality and extraprostatic extension (EPE). RESULTS:Identification and characterization by PHS of the index tumour in the 14 patients in the test set correlated closely (r = 0.95, P < 0.001) with the reference test. The concordance in the attribution of multifocality (present/absent), unilateral/bilateral disease between PHS and histology was 100%. EPE as determined by PHS was attributed to all three pT3a pathological specimens in the blinded paired data. In the same set of data, EPE was attributed to one prostate cancer that on pathological inspection was deemed to be organ-confined (pT2b). CONCLUSIONS:PHS has the potential to identify and characterize prostate cancer foci noninvasively. The precision appears to be sufficient to suggest that PHS might be useful as a triage test for men deemed to be at risk of prostate cancer and who wish to avoid prostate biopsy.

journal_name

BJU Int

journal_title

BJU international

authors

Braeckman J,Autier P,Garbar C,Marichal MP,Soviany C,Nir R,Nir D,Michielsen D,Bleiberg H,Egevad L,Emberton M

doi

10.1111/j.1464-410X.2007.07232.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

293-8

issue

eissn

1464-4096

issn

1464-410X

pii

BJU7232

journal_volume

101

pub_type

杂志文章

在线工具

Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer.