Abstract:
OBJECTIVE:To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. METHODS:Sensitivity analyses were used to assess the effects of: (i) the number of urological symptoms included in the cluster analysis; (ii) the use of ordinal vs dichotomous scaling of responses; (iii) the type of cluster analysis used (hierarchical vs non-hierarchical; random vs nonrandom seeds); and (iv) the distance metric (median difference vs root mean square) of the resulting clusters. These sensitivity analyses were conducted independently in each of the two studies, with results systematically compared using Cramer's V statistic. Contingency tables were also used to assess the frequency of transitions or change in classification from one method to another. RESULTS:There were marked similarities in the cluster profiles in men and women across the two studies. For both men and women, the largest clusters consisted of low-frequency, single-symptom profiles, with urinary frequency and urgency symptoms reported by both genders. There was a multiple, mixed and highly symptomatic cluster profile in both genders in the Boston Area Community Health (BACH) and EPIC studies. The sensitivity analyses showed stability across both BACH and EPIC studies, and varying cluster methods and solutions (Cramer's V, 0.37-0.93). CONCLUSION:Sensitivity analyses show that cluster profiles are quite robust from EPIC to BACH, and that gender profiles within studies are relatively consistent across the methods and variables examined. Further studies are needed to investigate the mechanisms of action and clinical management implications of these findings.
journal_name
BJU Intjournal_title
BJU internationalauthors
Rosen RC,Coyne KS,Henry D,Link CL,Cinar A,Aiyer LP,Mollon P,Kaplan SA,Roehrborn CG,Thompson Cdoi
10.1111/j.1464-410X.2008.07653.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
1274-8issue
10eissn
1464-4096issn
1464-410Xpii
BJU7653journal_volume
101pub_type
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journal_title:BJU international
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07594.x
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journal_title:BJU international
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doi:10.1111/j.1464-410X.2008.07921.x
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
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doi:10.1046/j.1464-410x.2001.02375.x
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08240.x
更新日期:2009-05-01 00:00:00
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更新日期:2015-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07558.x
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11152.x
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09787.x
更新日期:2011-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.12388
更新日期:2013-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00931.x
更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05398.x
更新日期:2005-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14568
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pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10464.x
更新日期:2011-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02221.x
更新日期:2001-06-01 00:00:00
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.12262
更新日期:2014-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-4096.2001.01458.x
更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07115.x
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.12387
更新日期:2014-02-01 00:00:00
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doi:10.1111/j.1464-410X.2011.10315.x
更新日期:2012-01-01 00:00:00