Abstract:
:Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents, such as cisplatin and etoposide, have produced responses of ≈15-30%, with median survival figures of ≈6-15 months, depending on case selection bias, with only <10% 5-year survival rates. Recent preclinical and pathological studies have indicated a range of potential targets for drugs, including WNT/beta-catenin, epidermal growth factor receptor, RAF and k-RAS; similar applications in melanoma and renal carcinoma have achieved significant gains, and these targets are worthy of further, structured investigation. Advanced adrenal carcinoma constitutes an orphan disease, with a high mortality rate, and merits investment in clinical trials.
journal_name
BJU Intjournal_title
BJU internationalauthors
Costa R,Wesolowski R,Raghavan Ddoi
10.1111/j.1464-410X.2011.10464.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
1546-54issue
10eissn
1464-4096issn
1464-410Xjournal_volume
108pub_type
杂志文章,评审abstract:OBJECTIVES:To determine the clinical utility of blood tests as a screening tool for metabolic abnormalities in patients with kidney stone disease. SUBJECTS AND METHODS:Clinical and biochemical data from 709 patients attending the Oxford University Hospitals NHS Foundation Trust for assessment and treatment of kidney s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15250
更新日期:2020-09-23 00:00:00
abstract:OBJECTIVES:To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria. PATIENTS AND METHODS:We conducted a retrospective single-centre analysis of 247 consecutive patients. The recruitment period was January 2001 to October 2015. A total of 328 inflata...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14027
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of oxidized cellulose, Surgicel(TM) (Johnson & Johnson Medical, New Brunswick, NJ, USA) for patching defects in the tunica albuginea in a rabbit model, with a future application to correct chordee. MATERIALS AND METHODS:The study comprised nine New Zealand white male rabbits; a recta...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06684.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To determine the most frequent urodynamic observations associated with bladder calculi, and to assess whether the presence of calculi alters these observations. PATIENTS AND METHODS:Fifty patients with bladder stones were included in a prospective study in which two urodynamic tests were used, one at inclus...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04815.x
更新日期:2004-06-01 00:00:00
abstract::Three-dimensional (3D) printing or additive manufacturing is a new technology that has seen rapid development in recent years with decreasing costs. 3D printing allows the creation of customised, finely detailed constructs. Technological improvements, increased printer availability, decreasing costs, improved cell cul...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14928
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effectiveness of a combined treatment of 3-30-methylene-bis[4-hydroxycoumarin] (dicoumarol) with doxorubicin for the treatment of urothelial cancer, as doxorubicin is a common chemotherapeutic agent but its therapeutic efficacy is limited. MATERIALS AND METHODS:The synergistic effect of di...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08732.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse of testicular germ cell tumours (TGCTs), in the follow-up of TGCTs for detecting tumour relapse, as it has role as a prognostic factor but its role in follow-up is less certain. PATIEN...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06905.x
更新日期:2007-07-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10813.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To determine the outcome 10 years after an individual course of pelvic floor muscle (PFM) exercises for genuine stress incontinence. PATIENTS AND METHODS:Postal questionnaires were sent to 52 women who had undergone PFM training 10 years earlier, and their medical files were reviewed. The main outcome measur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00506.x
更新日期:2000-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incid...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11057.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To assess the potentiation of erectile responses induced by electrical stimulation (ES) of the dorsal penile nerve (DPN) in the urethane-anaesthetized rat by the selective melanocortin receptor 4 agonist MB243. MATERIALS AND METHODS:Intracavernosal and blood pressures (ICP and BP, respectively) were monitore...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07751.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To assess in detail and evaluate the effect on survival of delays in the diagnosis and treatment of cancer (which might lead to a worse prognosis), dividing the delay from onset of symptoms to first treatment into several components, comprising patient delay, general practitioner (GP) delay, and two or more p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02776.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To examine differences in gene expression levels between renal cell carcinoma (RCC) tissue and 'normal' appearing renal tissue using a commercially available DNA macroarray. MATERIALS AND METHODS:Tissue was obtained from 47 consecutive radical nephrectomies, 29 of which were eligible. DNA macroarrays were an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06209.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To summarize the urological procedures recorded in Hospital Episodes Statistics (HES, 1998-99) and to examine the accuracy of coding and HES. MATERIALS AND METHODS:Data on the 10 commonest urological procedures from the Department of Health website (www.doh.gov.uk/hes) were extracted, summarized and presente...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02833.x
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To report a contemporary series of patients with xanthogranulomatous pyelonephritis (XGP, an inflammatory condition of the kidney that has traditionally been treated with open nephrectomy, ON), managed with either ON or laparoscopic nephrectomy (LN), as early reports suggest that the benefits of LN do not ext...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08547.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the functional and cosmetic results and patient satisfaction after triple incision plasty for phimosis in children. PATIENTS AND METHODS:The study included 197 boys who had a triple incision for phimosis (mean age 5.8 years, range 0.25-18). The indications for preputial surgery were recurrent bal...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04354.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To assess whether under- or overweight at the time of surgery has any effect on the survival of the patients with renal cell carcinoma (RCC), as obesity increases the risk of developing RCC. PATIENTS AND METHODS:We prospectively evaluated 780 patients who had nephrectomy for RCC between 1990 and 2005. We use...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07375.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy, evaluate the safety and assess side-effects (swelling, haematoma and pain) of percutaneous vas occlusion compared with vasectomy in Dutch men. PATIENTS AND METHODS:Vas occlusion and vasectomy procedures (attempted in 58 and 50 men, respectively) were conducted at the University Ho...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00875.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:• To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of ureteral war injury using a canine model. MATERIALS AND METHODS:• A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (G...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09992.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12732
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To assess the use of demucosalized ileum for bladder augmentation, following the same principles previously used with the sigmoid colon. PATIENTS AND METHODS:Eleven patients with bladder exstrophy or a neurogenic bladder had their bladders augmented with demucosalized ileum instead of the sigmoid colon, but ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.lima.2465.x
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of desmopressin nasal spray on daytime urinary incontinence in women. PATIENTS AND METHODS:A multicentre, multinational, randomized, double-blind, placebo-controlled, cross-over exploratory study of women (aged 18-80 years) complaining of severe daytime urinary incontinence was co...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.04768.x
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12333
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To determine whether men with premature ejaculation who fail to respond to 25 mg clomipramine as needed improve when taking 10-30 mg clomipramine daily. SUBJECTS AND METHODS:Four men with premature ejaculation whose ejaculation latencies increased minimally or not at all when taking 25 mg clomipramine as nee...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00112.x
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To present early outcome data from patients treated for invasive penile cancers with organ-sparing surgery, as the treatment of such malignancies has traditionally either been amputative surgery or radical radiotherapy, both associated with significant physical and psychosexual morbidity. PATIENTS AND METHOD...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05153.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of renal function on the stone-free rate (SFR) of proximal ureteric stones (PUS) after extracorporeal shock wave lithotripsy (ESWL), as urinary obstruction caused by PUS can impair renal function, and elevated serum creatinine levels are associated with decreased ureteric stone passa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08974.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To use the Fragility Index to evaluate the robustness of statistically significant findings from urological randomised controlled trials (RCTs). MATERIALS AND METHODS:The 'Fragility Index' is defined as the minimum number of patients in one arm of a trial whose status would have to change from 'event' to 'n...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14210
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10434.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To examine the results of open partial nephrectomy (OPN) over a 15-year period in a large UK teaching hospital and to compare results with other series including minimally invasive techniques, as nephron-sparing techniques are still under-utilized in the surgical treatment of renal carcinoma. A standardized ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07829.x
更新日期:2008-11-01 00:00:00