Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?

Abstract:

:Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents, such as cisplatin and etoposide, have produced responses of ≈15-30%, with median survival figures of ≈6-15 months, depending on case selection bias, with only <10% 5-year survival rates. Recent preclinical and pathological studies have indicated a range of potential targets for drugs, including WNT/beta-catenin, epidermal growth factor receptor, RAF and k-RAS; similar applications in melanoma and renal carcinoma have achieved significant gains, and these targets are worthy of further, structured investigation. Advanced adrenal carcinoma constitutes an orphan disease, with a high mortality rate, and merits investment in clinical trials.

journal_name

BJU Int

journal_title

BJU international

authors

Costa R,Wesolowski R,Raghavan D

doi

10.1111/j.1464-410X.2011.10464.x

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1546-54

issue

10

eissn

1464-4096

issn

1464-410X

journal_volume

108

pub_type

杂志文章,评审
  • Utility of blood tests in screening for metabolic disorders in kidney stone disease.

    abstract:OBJECTIVES:To determine the clinical utility of blood tests as a screening tool for metabolic abnormalities in patients with kidney stone disease. SUBJECTS AND METHODS:Clinical and biochemical data from 709 patients attending the Oxford University Hospitals NHS Foundation Trust for assessment and treatment of kidney s...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.15250

    authors: Eyre KS,Lewis F,Cui H,Grout E,Mihai R,Turney BW,Howles SA

    更新日期:2020-09-23 00:00:00

  • Outcomes of inflatable penile prosthesis insertion in 247 patients completing female to male gender reassignment surgery.

    abstract:OBJECTIVES:To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria. PATIENTS AND METHODS:We conducted a retrospective single-centre analysis of 247 consecutive patients. The recruitment period was January 2001 to October 2015. A total of 328 inflata...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14027

    authors: Falcone M,Garaffa G,Gillo A,Dente D,Christopher AN,Ralph DJ

    更新日期:2018-01-01 00:00:00

  • Use of oxidized cellulose for corporal body grafting and suture-less correction of severe penile chordee: an experimental study in rabbits.

    abstract:OBJECTIVE:To evaluate the efficacy of oxidized cellulose, Surgicel(TM) (Johnson & Johnson Medical, New Brunswick, NJ, USA) for patching defects in the tunica albuginea in a rabbit model, with a future application to correct chordee. MATERIALS AND METHODS:The study comprised nine New Zealand white male rabbits; a recta...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06684.x

    authors: El-Assmy A,Eassa W,El-Hamid MA,Nour EM,Hafez AT

    更新日期:2007-05-01 00:00:00

  • Urodynamic findings before and after noninvasive management of bladder calculi.

    abstract:OBJECTIVES:To determine the most frequent urodynamic observations associated with bladder calculi, and to assess whether the presence of calculi alters these observations. PATIENTS AND METHODS:Fifty patients with bladder stones were included in a prospective study in which two urodynamic tests were used, one at inclus...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.04815.x

    authors: Millán-Rodríguez F,Errando-Smet C,Rousaud-Barón F,Izquierdo-Latorre F,Rousaud-Barón A,Villavicencio-Mavrich H

    更新日期:2004-06-01 00:00:00

  • Current applications of three-dimensional printing in urology.

    abstract::Three-dimensional (3D) printing or additive manufacturing is a new technology that has seen rapid development in recent years with decreasing costs. 3D printing allows the creation of customised, finely detailed constructs. Technological improvements, increased printer availability, decreasing costs, improved cell cul...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14928

    authors: Chen MY,Skewes J,Desselle M,Wong C,Woodruff MA,Dasgupta P,Rukin NJ

    更新日期:2020-01-01 00:00:00

  • Dicoumarol enhances doxorubicin-induced cytotoxicity in p53 wild-type urothelial cancer cells through p38 activation.

    abstract:OBJECTIVE:To investigate the effectiveness of a combined treatment of 3-30-methylene-bis[4-hydroxycoumarin] (dicoumarol) with doxorubicin for the treatment of urothelial cancer, as doxorubicin is a common chemotherapeutic agent but its therapeutic efficacy is limited. MATERIALS AND METHODS:The synergistic effect of di...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08732.x

    authors: Matsui Y,Watanabe J,Ding S,Nishizawa K,Kajita Y,Ichioka K,Saito R,Kobayashi T,Ogawa O,Nishiyama H

    更新日期:2010-02-01 00:00:00

  • The utility of lactate dehydrogenase in the follow-up of testicular germ cell tumours.

    abstract:OBJECTIVE:To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse of testicular germ cell tumours (TGCTs), in the follow-up of TGCTs for detecting tumour relapse, as it has role as a prognostic factor but its role in follow-up is less certain. PATIEN...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.06905.x

    authors: Venkitaraman R,Johnson B,Huddart RA,Parker CC,Horwich A,Dearnaley DP

    更新日期:2007-07-01 00:00:00

  • Association between obesity and alteration of sperm DNA integrity and mitochondrial activity.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10813.x

    authors: Fariello RM,Pariz JR,Spaine DM,Cedenho AP,Bertolla RP,Fraietta R

    更新日期:2012-09-01 00:00:00

  • A 10-year follow-up after Kegel pelvic floor muscle exercises for genuine stress incontinence.

    abstract:OBJECTIVE:To determine the outcome 10 years after an individual course of pelvic floor muscle (PFM) exercises for genuine stress incontinence. PATIENTS AND METHODS:Postal questionnaires were sent to 52 women who had undergone PFM training 10 years earlier, and their medical files were reviewed. The main outcome measur...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00506.x

    authors: Cammu H,Van Nylen M,Amy JJ

    更新日期:2000-04-01 00:00:00

  • Gleason 7 prostate cancer treated with low-dose-rate brachytherapy: lack of impact of primary Gleason pattern on biochemical failure.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incid...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11057.x

    authors: Stock RG,Berkowitz J,Blacksburg SR,Stone NN

    更新日期:2012-11-01 00:00:00

  • Potentiation of reflex erectile responses in the anaesthetized rat by the selective melanocortin receptor 4 agonist MB243.

    abstract:OBJECTIVE:To assess the potentiation of erectile responses induced by electrical stimulation (ES) of the dorsal penile nerve (DPN) in the urethane-anaesthetized rat by the selective melanocortin receptor 4 agonist MB243. MATERIALS AND METHODS:Intracavernosal and blood pressures (ICP and BP, respectively) were monitore...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07751.x

    authors: Allard J,Reynolds DS,Edmunds NJ

    更新日期:2008-09-01 00:00:00

  • Delay and survival in bladder cancer.

    abstract:OBJECTIVE:To assess in detail and evaluate the effect on survival of delays in the diagnosis and treatment of cancer (which might lead to a worse prognosis), dividing the delay from onset of symptoms to first treatment into several components, comprising patient delay, general practitioner (GP) delay, and two or more p...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02776.x

    authors: Wallace DM,Bryan RT,Dunn JA,Begum G,Bathers S,West Midlands Urological Research Group.

    更新日期:2002-06-01 00:00:00

  • Clinically unconfirmed positive urinary cytology: diagnostic implications and oncological outcomes.

    abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10210.x

    authors: Aharony S,Baniel J,Yossepowitch O

    更新日期:2011-10-01 00:00:00

  • Gene expression profiling of renal cell carcinoma: a DNA macroarray analysis.

    abstract:OBJECTIVE:To examine differences in gene expression levels between renal cell carcinoma (RCC) tissue and 'normal' appearing renal tissue using a commercially available DNA macroarray. MATERIALS AND METHODS:Tissue was obtained from 47 consecutive radical nephrectomies, 29 of which were eligible. DNA macroarrays were an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06209.x

    authors: Lovisolo JA,Casati B,Clerici L,Marafante E,Bono AV,Celato N,Salvadore M

    更新日期:2006-07-01 00:00:00

  • The 'top 10' urological procedures: a study of hospital episodes statistics 1998-99.

    abstract:OBJECTIVE:To summarize the urological procedures recorded in Hospital Episodes Statistics (HES, 1998-99) and to examine the accuracy of coding and HES. MATERIALS AND METHODS:Data on the 10 commonest urological procedures from the Department of Health website (www.doh.gov.uk/hes) were extracted, summarized and presente...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02833.x

    authors: Lee F,Patel HR,Emberton M

    更新日期:2002-07-01 00:00:00

  • Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy.

    abstract:OBJECTIVE:To report a contemporary series of patients with xanthogranulomatous pyelonephritis (XGP, an inflammatory condition of the kidney that has traditionally been treated with open nephrectomy, ON), managed with either ON or laparoscopic nephrectomy (LN), as early reports suggest that the benefits of LN do not ext...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08547.x

    authors: Guzzo TJ,Bivalacqua TJ,Pierorazio PM,Varkarakis J,Schaeffer EM,Allaf ME

    更新日期:2009-11-01 00:00:00

  • Triple incision to treat phimosis in children: an alternative to circumcision?

    abstract:OBJECTIVE:To evaluate the functional and cosmetic results and patient satisfaction after triple incision plasty for phimosis in children. PATIENTS AND METHODS:The study included 197 boys who had a triple incision for phimosis (mean age 5.8 years, range 0.25-18). The indications for preputial surgery were recurrent bal...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04354.x

    authors: Fischer-Klein Ch,Rauchenwald M

    更新日期:2003-09-01 00:00:00

  • The influence of body mass index on the long-term survival of patients with renal cell carcinoma after tumour nephrectomy.

    abstract:OBJECTIVE:To assess whether under- or overweight at the time of surgery has any effect on the survival of the patients with renal cell carcinoma (RCC), as obesity increases the risk of developing RCC. PATIENTS AND METHODS:We prospectively evaluated 780 patients who had nephrectomy for RCC between 1990 and 2005. We use...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07375.x

    authors: Haferkamp A,Pritsch M,Bedke J,Wagener N,Pfitzenmaier J,Buse S,Hohenfellner M

    更新日期:2008-05-01 00:00:00

  • Efficacy of percutaneous vas occlusion compared with conventional vasectomy.

    abstract:OBJECTIVES:To determine the efficacy, evaluate the safety and assess side-effects (swelling, haematoma and pain) of percutaneous vas occlusion compared with vasectomy in Dutch men. PATIENTS AND METHODS:Vas occlusion and vasectomy procedures (attempted in 58 and 50 men, respectively) were conducted at the University Ho...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00875.x

    authors: Zambon JV,Barone MA,Pollack AE,Mehta M

    更新日期:2000-10-01 00:00:00

  • Introduction to biodegradable polylactic acid ureteral stent application for treatment of ureteral war injury.

    abstract:OBJECTIVE:• To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of ureteral war injury using a canine model. MATERIALS AND METHODS:• A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (G...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09992.x

    authors: Li G,Wang ZX,Fu WJ,Hong BF,Wang XX,Cao L,Xu FQ,Song Q,Cui FZ,Zhang X

    更新日期:2011-09-01 00:00:00

  • The impact of androgen-deprivation therapy (ADT) on the risk of cardiovascular (CV) events in patients with non-metastatic prostate cancer: a population-based study.

    abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12732

    authors: Gandaglia G,Sun M,Popa I,Schiffmann J,Abdollah F,Trinh QD,Saad F,Graefen M,Briganti A,Montorsi F,Karakiewicz PI

    更新日期:2014-12-01 00:00:00

  • Experience with demucosalized ileum for bladder augmentation.

    abstract:OBJECTIVE:To assess the use of demucosalized ileum for bladder augmentation, following the same principles previously used with the sigmoid colon. PATIENTS AND METHODS:Eleven patients with bladder exstrophy or a neurogenic bladder had their bladders augmented with demucosalized ileum instead of the sigmoid colon, but ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-4096.2001.lima.2465.x

    authors: Lima SV,Araújo LA,Vilar FO,Mota D,Maciel A

    更新日期:2001-11-01 00:00:00

  • Antidiuresis: a new concept in managing female daytime urinary incontinence.

    abstract:OBJECTIVE:To investigate the efficacy of desmopressin nasal spray on daytime urinary incontinence in women. PATIENTS AND METHODS:A multicentre, multinational, randomized, double-blind, placebo-controlled, cross-over exploratory study of women (aged 18-80 years) complaining of severe daytime urinary incontinence was co...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2004.04768.x

    authors: Robinson D,Cardozo L,Akeson M,Hvistendahl G,Riis A,Norgaard JP

    更新日期:2004-05-01 00:00:00

  • Prostate histotripsy: evaluation of prostatic urethral treatment parameters in a canine model.

    abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12333

    authors: Schade GR,Styn NR,Ives KA,Hall TL,Roberts WW

    更新日期:2014-03-01 00:00:00

  • Effective daily treatment with clomipramine in men with premature ejaculation when 25 mg (as required) is ineffective.

    abstract:OBJECTIVE:To determine whether men with premature ejaculation who fail to respond to 25 mg clomipramine as needed improve when taking 10-30 mg clomipramine daily. SUBJECTS AND METHODS:Four men with premature ejaculation whose ejaculation latencies increased minimally or not at all when taking 25 mg clomipramine as nee...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.00112.x

    authors: Rowland DL,De Gouveia Brazao CA,Koos Slob A

    更新日期:2001-03-01 00:00:00

  • Organ-sparing surgery for invasive penile cancer: early follow-up data.

    abstract:OBJECTIVE:To present early outcome data from patients treated for invasive penile cancers with organ-sparing surgery, as the treatment of such malignancies has traditionally either been amputative surgery or radical radiotherapy, both associated with significant physical and psychosexual morbidity. PATIENTS AND METHOD...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05153.x

    authors: Pietrzak P,Corbishley C,Watkin N

    更新日期:2004-12-01 00:00:00

  • Chronic kidney disease affects the stone-free rate after extracorporeal shock wave lithotripsy for proximal ureteric stones.

    abstract:OBJECTIVE:To investigate the effect of renal function on the stone-free rate (SFR) of proximal ureteric stones (PUS) after extracorporeal shock wave lithotripsy (ESWL), as urinary obstruction caused by PUS can impair renal function, and elevated serum creatinine levels are associated with decreased ureteric stone passa...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08974.x

    authors: Hung SF,Chung SD,Wang SM,Yu HJ,Huang HS

    更新日期:2010-04-01 00:00:00

  • The fragility of statistically significant findings from randomised controlled trials in the urological literature.

    abstract:OBJECTIVES:To use the Fragility Index to evaluate the robustness of statistically significant findings from urological randomised controlled trials (RCTs). MATERIALS AND METHODS:The 'Fragility Index' is defined as the minimum number of patients in one arm of a trial whose status would have to change from 'event' to 'n...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14210

    authors: Narayan VM,Gandhi S,Chrouser K,Evaniew N,Dahm P

    更新日期:2018-07-01 00:00:00

  • Cost-effectiveness analysis of degarelix for advanced hormone-dependent prostate cancer.

    abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10434.x

    authors: Lu L,Peters J,Roome C,Stein K

    更新日期:2012-04-01 00:00:00

  • Nephron-sparing surgery: a call for greater application of established techniques.

    abstract:OBJECTIVES:To examine the results of open partial nephrectomy (OPN) over a 15-year period in a large UK teaching hospital and to compare results with other series including minimally invasive techniques, as nephron-sparing techniques are still under-utilized in the surgical treatment of renal carcinoma. A standardized ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07829.x

    authors: Young JG,Luscombe CJ,Lynch C,Wallace DM

    更新日期:2008-11-01 00:00:00